add2
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  • Official Full Name
  • adducin 2 (beta)
  • Background
  • Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.
  • Synonyms
  • ADD2; adducin 2 (beta); beta-adducin; ADDB; ADD 2; ADDB_HUMAN; Adducin2; Beta adducin; Erythrocyte adducin subunit beta; OTTHUMP00000203378; OTTHUMP00000203908
Cat.#:ADD2-337HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADD2 Protein, GST-tagged
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Cat.#:ADD2-9414HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADD2, His-tagged
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Cat.#:ADD2-1351MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADD2 Protein
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Cat.#:ADD2-243RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADD2 Protein, His-tagged
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Cat.#:ADD2-9015HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADD2 293 Cell Lysate
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Cat.#:ADD2-9016HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADD2 293 Cell Lysate
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Involved Pathway

ADD2 involved in several pathways and played different roles in them. We selected most pathways ADD2 participated on our site, such as Miscellaneous transport and binding events, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Miscellaneous transport and binding events
CTNS; ANKHA; ANKHB; NIPA1; AZGP1; DMTN; EPB49; ADD1; ADD3A; PIP
Transmembrane transport of small molecules
TTYH1; MIPB; SLC24A5; SLCO4C1; SLC41A1; SLC9A3.1; ANO1; FXYD6-FXYD2; TFR1B; TRPC4B

Protein Function

ADD2 has several biochemical functions, for example, actin binding, actin filament binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD2 itself. We selected most functions ADD2 had, and list some proteins which have the same functions with ADD2. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein VPS16; EPS8L1; VCL; MKL1; INPPL1; MYH1E; STK38L; TPM2; VILL; WASH1
Function actin filament binding
Related Protein TMOD4; ACTN4; CTNNA3; ACTN2; KLHL17; MYO10; FSCN3; EZR; MACF1; SVIL
Function calmodulin binding
Related Protein KCNN1B; ARPP21; NOS2; MARCKSA; CNN1; ASPM; MYO1G; TRPV6; AKAP5; MYO1D
Function protein heterodimerization activity
Related Protein HIST1H4B; TAF11; SPTA1; DR1; CASP8; NPAS4; PDSS1; LIMK2; HIST1H2AI; SOX17
Function protein homodimerization activity
Related Protein SDCBP; MCL1B; SNX6; ALDH5A1; DCK; MTMR2; GLA; UPK1A; IL6R; SYNE1
Function spectrin binding
Related Protein KIF3A; ADD2; MYO10; UNC13A; STX4A; DYNC1I1; SLC26A5; MYO7A; GBP1; EPB41

ADD2 Related Articles

Farghaian, H; Turnley, AM; et al. Bioinformatic Prediction and Confirmation of beta-Adducin as a Novel Substrate of Glycogen Synthase Kinase 3. JOURNAL OF BIOLOGICAL CHEMISTRY 286:25274-25283(2011).
Ogawa, Y; Rasband, MN; et al. Proteomic Analysis of Optic Nerve Lipid Rafts Reveals New Paranodal Proteins. JOURNAL OF NEUROSCIENCE RESEARCH 87:3502-3510(2009).