adrb1
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  • Official Full Name
  • adrenergic, beta-1-, receptor
  • Background
  • The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.
  • Synonyms
  • ADRB1; adrenergic, beta-1-, receptor; beta-1 adrenergic receptor; ADR B1; ADRB 1; ADRB1_HUMAN; ADRB1R; Adrenergic beta 1 receptor; B1AR; Beta 1 adrenoceptor; Beta 1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR
Cat.#:ADRB1-1319HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ADRB1 Protein (378-477 aa), His-tagged
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Cat.#:ADRB1-01HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human ADRB1 Protein, His-tagged
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Cat.#:ADRB1-1017HTag:Flag/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Adrenergic, Beta-1-, Receptor, Flag-His
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Cat.#:ADRB1-1035HTag:
Source (Host):Species:Human
Product nameRecombinant Human ADBR1 and GsαS fusion protein, Flag and His-tagged
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Cat.#:ADRB1-1385MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADRB1 Protein
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Cat.#:ADRB1-544RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADRB1 Protein
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Cat.#:ADRB1-259RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADRB1 Protein, His-tagged
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Cat.#:ADRB1-6980ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADRB1
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Cat.#:Kit-1082Tag:
Source (Host):Species:
Product namePhospholipase A2 Activity Assay Kit (Fluorometric)
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Cat.#:Kit-1113Tag:
Source (Host):Species:
Product nameCystathionine β Synthase Activity Assay Kit (Fluorometric)
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Cat.#:Kit-2183Tag:
Source (Host):Species:
Product namecAMP ADRB1 CHO-K1 GPCR Assay Kit
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Cat.#:Kit-2184Tag:
Source (Host):Species:
Product nameADRB1 CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-1112Tag:
Source (Host):Species:
Product nameProtein Synthesis Monitoring Assay Kit (Flow Cytometry)
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Cat.#:Kit-0966Tag:
Source (Host):Species:
Product nameTR-FRET LXR beta Coactivator Assay Kit, goat
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Involved Pathway

ADRB1 involved in several pathways and played different roles in them. We selected most pathways ADRB1 participated on our site, such as Adrenergic signaling in cardiomyocytes, Adrenoceptors, Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenergic signaling in cardiomyocytes
TPM4A; PIK3R1; PPP2R1B; PPP2R3C; PPP2R5D; ATP2B4; CREB3L3L; GNA15.1; ATP2B1A; TNNC1A
Adrenoceptors
ADRA2B; ADRa1A; ADRB2; ADRA1B; ADRB1; ADRA2A; ADRA1D; ADRB3; ADRA2C
Amine ligand-binding receptors
TAAR1; ADRA1B; DRD3; ADRA2C; CHRM5; ADRA2B; ADRB1; ADRB3; DRD1; ADRA2A
Calcium Regulation in the Cardiac Cell
FKBP1A; GNB5B; GJB1; ANXA6; GJA8; RGS17; ADRB2; GJA5; CX34.4; CHRM3
Calcium signaling pathway
TACR3L; HTR2CL1; PRKACA; PRKCA; ADCY2B; MLCK2; CYSLTR1; ATP2A2; CALML3; GRIN1A
Class A/1 (Rhodopsin-like receptors)
QRFPR; OPN1MW2; GPR4; OPN4.1; CYSLTR1; NMUR1; GPR31B; PNOC; OPN1LW; GPR68
Dilated cardiomyopathy
MYL2; CACNA2D1; Adcy4; ITGA10; PRKACG; ATP2A2; TNF; TPM3; MYBPC3; PLN
Endocytosis
RAB7A; IL2RA; WIPF2; RAB35B; ARPC4L; FMNL3; TSG101; ZFYVE9; PSD2; SNX32

Protein Function

ADRB1 has several biochemical functions, for example, PDZ domain binding, Ras guanyl-nucleotide exchange factor activity, alpha-2A adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB1 itself. We selected most functions ADRB1 had, and list some proteins which have the same functions with ADRB1. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein SDC2; CXXC4; ATP2B3B; SNTA1; NKD1; ARHGEF16; LIN7B; LNX2; GRIK2; LNX1
Function Ras guanyl-nucleotide exchange factor activity
Related Protein ADRB1; RAPGEF4; RASGEF1B; RAB3A; RGL2; RASGEF1BB; SOS1; RAPGEF5; RASGEF1A; RASGRP4
Function alpha-2A adrenergic receptor binding
Related Protein ADRA2C; UCHL1; APLP1; ADRB1; ADRBK1
Function beta-adrenergic receptor activity
Related Protein ADRB3; ADRB1
Function beta1-adrenergic receptor activity
Related Protein ADRB1
Function epinephrine binding
Related Protein ADRB3B; ADRB2B; ADRB3; ADRB3A; ADRB2A; ADRB2; ADRB1; ADRA2A; ADRA2C; ADRA2B
Function norepinephrine binding
Related Protein ADRB1; ADRB3A; ADRB2; ADRA2A; ADRB3B
Function protein binding
Related Protein CEP164; HOOK2; GCH1; KTI12; RAB22A; EDEM1; CBLL1; ZNF511; ADCYAP1R1; ACPL2
Function protein heterodimerization activity
Related Protein OSTA; PDX1; TCF3A; H2AFZ; HER5; MAPK6; SMAD2; SNX6; CAV2; SNX2
Function receptor signaling protein activity
Related Protein CD3E; DOK5; NGF; TIAM2; DOK4; cgr2b; IL4R; SMAD1; TGFBR1; NCR1

Interacting Protein

ADRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB1.
MAGI2; MAGI3; Dlg4; GPRASP1; Dlg1; GPRASP2; MAGI1; GOPC; Gipc1; atenolol

ADRB1 Related Gene Family

GPCRs