adsl
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  • Official Full Name
  • adenylosuccinate lyase
  • Background
  • Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ADSL; adenylosuccinate lyase; Adenylosuccinase; AMPS; ASase; ASL; OTTHUMP00000199172; OTTHUMP00000199173; PUR8_HUMAN
Cat.#:ADSL-26897THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADSL, His-tagged
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Cat.#:ADSL-1526HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Adenylosuccinate Lyase , His-tagged
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Cat.#:ADSL-2494HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADSL, His tagged
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Cat.#:ADSL-389HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADSL Protein, GST-tagged
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Cat.#:ADSL-9449HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADSL, GST-tagged
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Cat.#:ADSL-1390MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADSL Protein
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Cat.#:Adsl-3187MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Adsl, His-tagged
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Cat.#:ADSL-7077CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADSL
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Cat.#:ADSL-10270ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADSL
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Cat.#:ADSL-8995HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADSL 293 Cell Lysate
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Involved Pathway

ADSL involved in several pathways and played different roles in them. We selected most pathways ADSL participated on our site, such as Alanine, aspartate and glutamate metabolism, Biosynthesis of antibiotics, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADSL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine, aspartate and glutamate metabolism
AGXT2; AGXTA; GOT2A; ybaS; RIMKLA; PPAT; CPS1; GPT2; GOT2; NAT8L
Biosynthesis of antibiotics
AK7; AKR1A1; AGXT; DAO; pykF; DLST; CMBL; ACAA2; UAP1L1; NME6
Metabolic pathways
PTS; PIK3C2B; NDUFB9; HSD3B2; CNDP2; FUT9A; OXSR1; TGDS; OCRL; CYP1A
Metabolism
NUDT11; CYP2AD2; DBH; LYVE1; COX7C; DDAH1; APOA4B.1; ACMSD; ACOT8; FABP9
Metabolism of nucleotides
PNP5B; ADAL; ADA; ADSSL1; ITPA; GRX2; DPYS; DCK; ADK; NUDT16
Nucleotide Metabolism
MTHFD2; ADSS; ADSL; OAZ1
Purine metabolism
POLR2GL; CANT1B; PDE6A; PNP6; URAD; ENTPD5; PDE7A; ENTPD1; GC3; GUCY2E
Purine ribonucleoside monophosphate biosynthesis
ADSS; PAICS; ADSSL1; ADSL

Protein Function

ADSL has several biochemical functions, for example, (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity, N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADSL itself. We selected most functions ADSL had, and list some proteins which have the same functions with ADSL. You can find most of the proteins on our site.
Function
Related Protein
Function (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
Related Protein ADSL
Function N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Related Protein ADSL
Function NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
Related Protein ADSL

Interacting Protein

ADSL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADSL here. Most of them are supplied by our site. Hope this information will be useful for your research of ADSL.
USP4; DDA1; USP15; NOV

ADSL Related Articles

Yuan, TA; Gu, JR; et al. Molecular cloning, characterization and expression analysis of adenylosuccinate lyase gene in grass carp (Ctenopharyngodon idella). MOLECULAR BIOLOGY REPORTS 38:2059-2065(2011).
Timmerman, P; Van Dijk, E; et al. Mapping of a discontinuous and highly conformational binding site on follicle stimulating hormone subunit-beta (FSH-beta) using domain Scan (TM) and Matrix Scan (TM) technology. MOLECULAR DIVERSITY 8:61-77(2004).