Recombinant Human ADSL, His-tagged
Cat.No. : | ADSL-26897TH |
Product Overview : | Recombinant full length protein, (amino acids 1-484) of Human Adenylosuccinate Lyase with N terminal His tag; 520 amino acids, 59 kDa inclusive of tag. |
- Specification
- Gene Information
- Related Products
Description : | Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 484 amino acids |
Conjugation : | HIS |
Molecular Weight : | 59.000kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 40% Glycerol, 0.58% Sodium chloride |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MRGSHHHHHHGMASMTGGQQMGRDL YDDDDKDRWGSMAAGGDHGSPDSYR SPLASRYASPEMCFVFSDRYKFRTW RQLWLWLAEAEQTLGLPITDEQIQE MKSNLENIDFKMAAEEEKRLRHDVM AHVHTFGHCCPKAAGIIHLGATSCY VGDNTDLIILRNALDLLLPKLARVI SRLADFAKERASLPTLGFTHFQPAQ LTTVGKRCCLWIQDLCMDLQNLKRV RDDLRFRGVKGTTGTQASFLQLFEG DDHKVEQLDKMVTEKAGFKRAFIIT GQTYTRKVDIEVLSVLASLGASVHK ICTDIRLLANLKEMEEPFEKQQIGS SAMPYKRNPMRSERCCSLARHLMTL VMDPLQTASVQWFERTLDDSANRRI CLAEAFLTADTILNTLQNISEGLVV YPKVIERRIRQELPFMATENIIMAM VKAGGSRQDCHEKIRVLSQQAASVV KQEGGDNDLIERIQVDAYFSPIHSQ LDHLLDPSSFTGRASQQVQRFLEEE VYPLLKPYESVMKVKAELCL |
Sequence Similarities : | Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. |
Gene Name : | ADSL adenylosuccinate lyase [ Homo sapiens ] |
Official Symbol : | ADSL |
Synonyms : | ADSL; adenylosuccinate lyase; |
Gene ID : | 158 |
mRNA Refseq : | NM_000026 |
Protein Refseq : | NP_000017 |
MIM : | 608222 |
Uniprot ID : | P30566 |
Chromosome Location : | 22q13.1 |
Pathway : | Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => |
Function : | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; NOT N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; N6-(1,2-; |
Products Types
◆ Recombinant Protein | ||
ADSL-0288H | Recombinant Human ADSL Protein (M1-L484), Tag Free | +Inquiry |
ADSL-90H | Recombinant Human ADSL Protein, His-tagged | +Inquiry |
ADSL-369M | Recombinant Mouse ADSL Protein, His (Fc)-Avi-tagged | +Inquiry |
ADSL-0289H | Recombinant Human ADSL Protein (M1-L484), His/Strep tagged | +Inquiry |
Adsl-549M | Recombinant Mouse Adsl Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ADSL-8995HCL | Recombinant Human ADSL 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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