ago2
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  • Official Full Name
  • argonaute RISC catalytic component 2
  • Background
  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Synonyms
  • AGO2; argonaute RISC catalytic component 2; Q10; EIF2C2; protein argonaute-2; PPD; hAgo2; eIF2C 2; eIF-2C 2; argonaute2; argonaute 2; protein slicer; PAZ Piwi domain protein; eukaryotic translation initiation factor 2C, 2;
Cat.#:AGO2-526HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGO2 Protein, MYC/DDK-tagged
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Cat.#:AGO2-2180HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AGO2, His tagged
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Cat.#:EIF2C2-2180HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EIF2C2, His-tagged
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Cat.#:AGO2-8477ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGO2
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Cat.#:AGO2-714HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AGO2 cell lysate
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Cat.#:AGO2-576MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse AGO2 cell lysate
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Involved Pathway

AGO2 involved in several pathways and played different roles in them. We selected most pathways AGO2 participated on our site, such as Adaptive Immune System, Beta-catenin independent WNT signaling, Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KLRG1; OSBPL1A; KIF18A; DCTN3; KIF26A; CD200R1; CDKN1B; FGF8B; SEC23A; RNF138
Beta-catenin independent WNT signaling
DVL1; GNB5; DVL2; CLTC; DVL3; PRICKLE1B; AP2B1; ROR2; CLTB; AP2A1
Ca2+ pathway
MOV10; AGO1; AGO2; AGO3; GNB5
DAP12 interactions
SPTBN1; FGF8B; DAB2IPB; PEA15A; RASGRP4; JAK1; PRKAR1AA; SPRED2; GRAP2A; FGFR1B
DAP12 signaling
SPRED2; FGFR1B; DUSP7; DUSP5; FRS2; JAK1; LCP2A; SPNA1; DUSP1; SPRED1
Downstream signal transduction
FGF18B; DUSP2; SPNA1; AGO2; FRS3; KBTBD7; FRS2B; SPRED2; MARK3; LAMTOR2
Downstream signaling events of B Cell Receptor (BCR)
AGO2
Downstream signaling of activated FGFR1
WDR83; RASGRP4; PEA15A; SPTB; SPRED3; DAB2IPB; IL17RD; DUSP9; MARK3; DUSP2

Protein Function

AGO2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding, RNA polymerase II core binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO2 itself. We selected most functions AGO2 had, and list some proteins which have the same functions with AGO2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA 7-methylguanosine cap binding
Related Protein DCPS; NCBP2; EIF4EA; AGO2
Function RNA polymerase II core binding
Related Protein GTF2E1; RPRD1B; KIAA1967; C14orf166; AGO2; WACA; ZNF326; PCF11; RECQL5; SMYD2B
Function core promoter binding
Related Protein SPI1; HNRNPU; NKX3-1; MYBBP1A; IRF9; E2F8; RB1; ELK4; XBP1; RBMX
Function double-stranded RNA binding
Related Protein OASL1; DROSHA; TLR7; DHX36; MTDH; STRBP; MBNL1; BARHL1; HMGB1; AGO1
Function endoribonuclease activity
Related Protein DROSHA; ENDOU; RNASEL; RNASEKA; CPSF3; NOB1; TSN; RNASEKB; RNASEK; RCL1
Function endoribonuclease activity, cleaving miRNA-paired mRNA
Related Protein AGO2
Function endoribonuclease activity, cleaving siRNA-paired mRNA
Related Protein AGO2
Function mRNA binding
Related Protein HNRNPAB; CPSF5; RBFOX1L; CSTF2T; QKI; DPPA5A; DXO; RBFOX3; HNRPLL; ESRP1
Function metal ion binding
Related Protein RHOV; NUDT17; MT2; PLRDGB; MCEE; CYP19A1B; MAP2K5; POGZA; ZFP474; FAM20B
Function miRNA binding
Related Protein PNPT1; DICER1; AGO4; POU5F1; MEF2C; EIF2C3; RBM4; TRIM71; TARBP2; AGO2
Function poly(A) RNA binding
Related Protein UTP15; FSCN1; SNRNP200; FAM120A; TAF15; ANXA11; DDX49; SRP54A; RPS15A; FAM46A
Function protein C-terminus binding
Related Protein CDK7; DDX1; TOP2A; PICK1; PXK; FIGN; TJP2; MIF4GD; ERCC3; RAD51
Function protein binding
Related Protein PLA2G16; PRUNE; PLOD3; GOLSYN; RPL7A; RTKN; NEK1; CIB2; QRICH1; RD3
Function siRNA binding
Related Protein TLR7; TARBP2; DICER1; MECP2; AGO2; TLR9
Function contributes_to siRNA binding
Related Protein AGO2
Function single-stranded RNA binding
Related Protein HNRNPF; JMJD6; STRBP; LUZP4; CBX4; ANXA1; IFIT5; DDX58; LONP1; PIWIL1
Function translation initiation factor activity
Related Protein EIF4E2RS1; EIF4G2; EIF3B; GTPBP2; EIF3E; EIF4E1B; EIF4A1A; EIF2B5; EIF2S1B; EIF1AXA

Interacting Protein

AGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO2.
DICER1; TNRC6B

AGO2 Related Articles

Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).
Bukong, TN; Momen-Heravi, F; et al. Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90. PLOS PATHOGENS 10:-(2014).