AGO2
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Official Full Name
argonaute RISC catalytic component 2 -
Overview
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] -
Synonyms
AGO2;argonaute RISC catalytic component 2;Q10;EIF2C2;protein argonaute-2;PPD;hAgo2;eIF2C 2;eIF-2C 2;argonaute2;argonaute 2;protein slicer;PAZ Piwi domain protein;eukaryotic translation initiation factor 2C, 2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Insect Cells
- E.coli
- HEK293
- Mammalian Cells
- Yeast
- His
- GST
- DDK
- Myc
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EIF2C2-2180H |
Active Recombinant Human EIF2C2, His-tagged
|
Insect Cells | Human | His | Met 1-Ala 859 | |
| AGO2-2180H |
Recombinant Human AGO2, His-tagged
|
Insect Cells | Human | His | Met 1-Ala 859 | |
| AGO2-3126H | Recombinant Human AGO2 protein, His-tagged | E.coli | Human | His | 603-780 aa | |
| AGO2-3693H | Recombinant Human AGO2 protein, GST-tagged | E.coli | Human | GST | ||
| AGO2-526H | Recombinant Human AGO2 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
|
|
| AGO2-8477Z | Recombinant Zebrafish AGO2 | Mammalian Cells | Zebrafish | His |
|
|
| AGO2-576MCL | Recombinant Mouse AGO2 cell lysate | Insect Cells | Mouse | Non |
|
|
| AGO2-714HCL | Recombinant Human AGO2 cell lysate | Insect Cells | Human | Non |
|
|
| AGO2-02H | Recombinant Human AGO2 Protein | E.coli | Human |
|
||
| Ago2-1556M | Recombinant Mouse Ago2 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
|
|
| AGO2-1728H | Recombinant Human AGO2 Protein (517-818 aa), His-tagged | Yeast | Human | His | 517-818 aa |
|
| AGO2-3112H | Recombinant Human AGO2 protein, GST-tagged | E.coli | Human | GST | 77-377 aa |
|
Involved Pathway
AGO2 involved in several pathways and played different roles in them. We selected most pathways AGO2 participated on our site, such as Adaptive Immune System,Beta-catenin independent WNT signaling,Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 interactions | DUSP10,JAK1,DUSP6,DUSP7,TRAT1,SPNA1,DUSP2,KIR3DS1,FGF8B,PEA15 |
| Adaptive Immune System | BLMH,UFL1,HUWE1,CTSO,PPIAL4A,ASB11,CD300LB,AGO3,KIF4A,LILRA3 |
| Downstream signaling of activated FGFR1 | IL17RD,MARK3,PEA15,PTPRA,DAB2IPB,SPRED1,SPNA1,PHB,PAQR3B,KBTBD7 |
| Ca2+ pathway | GNB5,AGO1,AGO3,MOV10 |
| DAP12 signaling | WDR83,JAK1,FRS2B,NRG3,MOV10,FGFR1B,PTPRA,PHB,TRAT1,JAK3 |
| Downstream signal transduction | DUSP7,FGF20A,RASGRP4,SPRED1,DUSP10,SPTB,PEA15,FGF18B,PHB,RASGEF1A |
| Beta-catenin independent WNT signaling | DVL2,CTNNB2,AP2A1,RYK,DVL1,GNB5,CLTC,ITPR2,PRICKLE1,DVL3 |
Protein Function
AGO2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding,RNA polymerase II core binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO2 itself. We selected most functions AGO2 had, and list some proteins which have the same functions with AGO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ZNF45,TRIM35-23,ARSI,CYP19A1B,KEL,ITGA9,KDM5BB,TRIM35-27,OTUD7A,ARL3 |
| poly(A) RNA binding | DDX6,ERH,PSMD4,SNRPD3,COX4I2,PTBP2,ISY1,GOT2,FXR2,NHP2L1 |
| core promoter binding | KDM3A,SFPI1,XBP1,NPAS2,NKX3,IFI16,E2F8,HDAC4,HDAC6,EP300 |
| single-stranded RNA binding | HNRNPF,JMJD6,PIWIL1,AGO1,ENDOV,TLR7,A1CF,DLX2,LONP1,TLR8 |
| miRNA binding | TARBP2,LIN28A,TRIM71,AGO4,POU5F1,AGO1,DICER1,AGO3,MEF2C,PNPT1 |
| translation initiation factor activity | EIF3S10,EIF2S1,EIF3HB,EIF3HA,EIF3JA,EIF1AXB,EIF4E1B,EIF3EA,GTPBP1L,BRF1A |
| mRNA binding | NANOS2,NXF2,RPS26,IGF2BP2A,SLBP,EIF4A3,TYMS,RBFOX1L,CLUHA,DXO |
| RNA 7-methylguanosine cap binding | DCPS,EIF4EA,NCBP2 |
| endoribonuclease activity | TSNAX,ENDOU2,TSN,ENDOU,DICER1,NOB1,SMG6,RNASEL,RCL1,RNASEKB |
Interacting Protein
AGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO2.
DICER1;TNRC6B
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References
- Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).
- Bukong, TN; Momen-Heravi, F; et al. Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90. PLOS PATHOGENS 10:-(2014).
