AGO2
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Official Full Name
argonaute RISC catalytic component 2
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Overview
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] -
Synonyms
AGO2; argonaute RISC catalytic component 2; Q10; EIF2C2; protein argonaute-2; PPD; hAgo2; eIF2C 2; eIF-2C 2; argonaute2; argonaute 2; protein slicer; PAZ Piwi domain protein; eukaryotic translation initiation factor 2C, 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Yeast
- GST
- His
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | EIF2C2-2180H | Active Recombinant Human EIF2C2, His-tagged | Insect Cell | His | Met 1-Ala 859 | |
| Human | AGO2-2180H |
Recombinant Human AGO2, His-tagged
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Insect Cell | His | Met 1-Ala 859 | |
| Human | AGO2-526H | Recombinant Human AGO2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | AGO2-714HCL | Recombinant Human AGO2 cell lysate | Insect Cell | N/A |
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| Human | AGO2-1728H | Recombinant Human AGO2 Protein (517-818 aa), His-tagged | Yeast | His | 517-818 aa |
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| Human | AGO2-3693H | Recombinant Human AGO2 protein, GST-tagged | E.coli | GST | ||
| Human | AGO2-3126H | Recombinant Human AGO2 protein, His-tagged | E.coli | His | 603-780 aa | |
| Human | AGO2-02H | Recombinant Human AGO2 Protein | E.coli |
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| Mouse | AGO2-576MCL | Recombinant Mouse AGO2 cell lysate | Insect Cell | N/A |
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| Mouse | AGO2-2241M | Recombinant Mouse AGO2 protein, His-tagged | Insect Cells | His | Met1-Ala860 |
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| Mouse | Ago2-1556M | Recombinant Mouse Ago2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Zebrafish | AGO2-8477Z | Recombinant Zebrafish AGO2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AGO2 Related Articles
AGO2 involved in several pathways and played different roles in them. We selected most pathways AGO2 participated on our site, such as Adaptive Immune System, Beta-catenin independent WNT signaling, Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | RAP1GAP2B;B2ML;SEC24A;LILRA3;CTSL1;STIM1B;RAET1E;CD200R2;MAP3K8 |
| Beta-catenin independent WNT signaling | AP2M1;ROR2;AP2A1;AP2A2;PRICKLE1;RYK;PRICKLE1B;AP2S1;CTNNB2 |
| Ca2+ pathway | AGO2;MOV10;AGO3;AGO1;GNB5 |
| DAP12 interactions | PRKAR1AA;DUSP4;SPNA2;IL17RD;KBTBD7;MOV10;KLB;FRS2;FGF20A |
| DAP12 signaling | JAK3;DUSP7;SPTBN2;DUSP6;LCP2A;NRG2A;FRS3;CNKSR1;DUSP5 |
| Downstream signal transduction | RASGEF1A;GRB7;PEA15A;SPTBN1;FGF20A;JAK1;PTPRA;FGF18B;SPTA1 |
| Downstream signaling events of B Cell Receptor (BCR) | |
| Downstream signaling of activated FGFR1 | MARK3;SPRED1;SPRED3;CNKSR1;DAB2IPB;PEA15;SPRED2;DUSP2;PAQR3A |
AGO2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding, RNA polymerase II core binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO2 itself. We selected most functions AGO2 had, and list some proteins which have the same functions with AGO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA 7-methylguanosine cap binding | EIF4EA;NCBP2;AGO2;DCPS |
| RNA polymerase II core binding | CTR9;SMYD3;WACA;GTF2E1;SMYD2A;AGO1;SMYD2;WAC;PCF11 |
| core promoter binding | SPI1;SFPI1;GATA1;NKX2-1;EZH2;GADD45A;MED1;AGO1;SFPQ |
| double-stranded RNA binding | ACTN1;OASL;RFTN1;TLR3;HSPD1;TFRC;TUBA1B;YRDC;MYH4 |
| endoribonuclease activity | NOB1;PLD6;TSN;RNASET2;TSNAX;RNASEL;RNASEKA;CPSF3;ERN1 |
| endoribonuclease activity, cleaving miRNA-paired mRNA | |
| endoribonuclease activity, cleaving siRNA-paired mRNA | |
| mRNA binding | HNRNPAB;XPO5;IGF2BP2A;CELF1;LUC7L3;RPL35;D19BWG1357E;MRPL13;FXR2 |
| metal ion binding | COL10A1;ROCK1;GZF1;DUS3L;GTF2E1;RFWD2;ZNF839;ZFP2;KDM3B |
| miRNA binding | AGO1;AGO3;SOX2;PNPT1;TRIM71;LIN28A;EIF2C3;TARBP2;AGO4 |
| poly(A) RNA binding | SART3;RPL7;EIF2C3;LRPPRC;PTRH1;RAVER2;MPHOSPH10;TCOF1;SRP19 |
| protein C-terminus binding | TJP2;DLG3;PEX16;NCL;ERBB2;PQBP1;VPS4A;CTGF;VGLL3 |
| protein binding | EHMT2;PAIP2;MRPL27;ATP6V1C2;NAIF1;PTMA;RCOR2;GNA12;LAPTM5 |
| siRNA binding | DICER1;TLR9;TARBP2;AGO2;MECP2;TLR7 |
| contributes_to siRNA binding | |
| single-stranded RNA binding | HNRNPF;AGO3;TLR7;NXF1;LSM14A;ENDOV;TLR8;A1CF;LUZP4 |
| translation initiation factor activity | EIF3EB;EIF4E1C;EIF4A2;MCTS1;EIF2S3;EIF2S2;EIF1B;EIF2S1B;EIF2D |
AGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO2.
DICER1; TNRC6B
- Q&As
- Reviews
Q&As (21)
Ask a questionResearch explores how AGO2 guides small RNAs to complementary target mRNA sequences.
Research explores AGO2’s role in guiding small RNAs to their target sequences.
Yes, AGO2 is part of the antiviral RNA interference pathway.
Yes, AGO2’s activity leads to the suppression or degradation of target mRNAs.
Research investigates AGO2’s connection to chromatin remodeling complexes.
AGO2 dysfunction is linked to disorders involving impaired gene regulation.
Yes, AGO2 is essential for normal development and cellular processes.
AGO2 plays a central role in mediating RNA silencing and post-transcriptional regulation.
AGO2 helps control gene expression by degrading or inhibiting mRNA translation.
Yes, AGO2’s function is important for maintaining stem cell populations.
Yes, AGO2’s activity can be regulated in response to cellular stress.
Yes, AGO2’s role in gene regulation is relevant in cancer studies.
Yes, AGO2’s role extends to epigenetic regulation through RNA-directed DNA methylation.
Yes, AGO2’s function is linked to post-transcriptional regulation of circadian genes.
Yes, AGO2’s activity can influence heterochromatin formation and genome stability.
AGO2’s activity leads to translational repression through mRNA cleavage or inhibition.
Yes, AGO2 is involved in suppressing transposable element activity.
AGO2 interacts with small RNAs, including microRNAs and small interfering RNAs.
Research explores AGO2’s contribution to targeting RNAs for exosome-mediated decay.
Research investigates AGO2’s role in regulating germline development and fertility.
AGO2’s activity impacts neuronal development and synaptic plasticity.
Customer Reviews (5)
Write a reviewThe high purity of the protein product facilitated accurate quantification of target molecules.
Well-defined gel electrophoresis bands were indicative of the protein product’s pure form.
Incorporating the product led to a noticeable increase in target protein expression levels.
Precise results from immunoprecipitation assays were attributed to the protein product’s purity.
Consistency across experiments made the protein product a reliable research tool.
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