AGO2

  • Official Full Name

    argonaute RISC catalytic component 2

  • Overview

    This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

  • Synonyms

    AGO2;argonaute RISC catalytic component 2;Q10;EIF2C2;protein argonaute-2;PPD;hAgo2;eIF2C 2;eIF-2C 2;argonaute2;argonaute 2;protein slicer;PAZ Piwi domain protein;eukaryotic translation initiation factor 2C, 2

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Insect Cells
  • E.coli
  • HEK293
  • Mammalian Cells
  • HeLa
  • Yeast
  • His
  • GST
  • DDK
  • Myc
  • Non
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF2C2-2180H Active Recombinant Human EIF2C2, His-tagged Insect Cells Human His Met 1-Ala 859
AGO2-2180H Recombinant Human AGO2, His-tagged Insect Cells Human His Met 1-Ala 859
AGO2-3126H Recombinant Human AGO2 protein, His-tagged E.coli Human His 603-780 aa
AGO2-3693H Recombinant Human AGO2 protein, GST-tagged E.coli Human GST
AGO2-526H Recombinant Human AGO2 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
AGO2-8477Z Recombinant Zebrafish AGO2 Mammalian Cells Zebrafish His
AGO2-576MCL Recombinant Mouse AGO2 cell lysate Insect Cells Mouse Non
AGO2-714HCL Recombinant Human AGO2 cell lysate Insect Cells Human Non
AGO2-029HKCL Human AGO2 Knockdown Cell Lysate HeLa Human Non
AGO2-02H Recombinant Human AGO2 Protein E.coli Human
Ago2-1556M Recombinant Mouse Ago2 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
AGO2-1728H Recombinant Human AGO2 Protein (517-818 aa), His-tagged Yeast Human His 517-818 aa
AGO2-3112H Recombinant Human AGO2 protein, GST-tagged E.coli Human GST 77-377 aa

    Involved Pathway

    AGO2 involved in several pathways and played different roles in them. We selected most pathways AGO2 participated on our site, such as Adaptive Immune System,Beta-catenin independent WNT signaling,Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DAP12 signaling GRAP2A,IL17RD,THEM4,NRG2A,FGF20A,PEA15,CSF2RB,KLB,KBTBD7,SPRED2
    Beta-catenin independent WNT signaling AGO1,AGO3,GNB5,AP2B1,CLTC,ROR1,DVL2,ITPR2,AP2S1,AP2M1
    DAP12 interactions SPNA2,CSF2RB,SIGLEC14,DUSP1,PTPRA,PRKAR1AA,CD300E,SPNA1,RASGEF1A,FGF20A
    Downstream signal transduction GRB7,DUSP10,PHB,IL17RD,FRS2A,PEA15,DUSP9,PEA15A,FGF8B,WDR83
    Ca2+ pathway AGO3,MOV10,GNB5,AGO1
    Downstream signaling of activated FGFR1 RASGEF1A,CNKSR1,SPTA1,IL17RD,PHB,PEA15A,PTPRA,RASGRP4,WDR83,SPTB
    Adaptive Immune System KLRB1B,KIF3B,AP2B1,RAPGEF3,AGO3,KIF4,DCTN3,EGFR,UBE2F,HBEGF

    Protein Function

    AGO2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding,RNA polymerase II core binding,core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO2 itself. We selected most functions AGO2 had, and list some proteins which have the same functions with AGO2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding COA5,DOK3,C4orf19,ZFYVE1,C19orf73,NAT9,MKL1,KCNQ1,SALL1,AACS
    RNA polymerase II core binding KIAA1967,KIAA1530,SMYD2B,RPRD1B,CDC73,PAF1,RECQL5,SMYD2,WACA,WAC
    poly(A) RNA binding MYH9,PABPC1,EIF4G3,PWP2,RPS6,RRS1,SAFB,FXR1,DIAP1,RPS21
    core promoter binding HDAC4,E2F8,EP300,CCAR1,AGO1,RB1,SFPQ,MYOD1,TFAP2C,HMGA2
    protein C-terminus binding HRAS,CLIC6,VGLL2,KCNK3,VIM,KPNA3,PEX12,PPP2CB,PEX1,PDZD11
    mRNA binding CELF4,NCBP2,PURB,IGF2BP1,MRPL13,HNRPLL,C1QBP,RBFOX1,CCDC55,NUDT16
    RNA 7-methylguanosine cap binding DCPS,NCBP2,EIF4EA
    metal ion binding IKZF1,ZC3H15,TET3,PLA2G2F,GNA12,ZNF274,PRDM13,KLF3,JMJD1C,ATX1
    siRNA binding TLR7,TARBP2,DICER1,TLR9,MECP2

    Interacting Protein

    AGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO2.

    DICER1;TNRC6B

    Resources

    References

    • Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).
    • Bukong, TN; Momen-Heravi, F; et al. Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90. PLOS PATHOGENS 10:-(2014).

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