ago2
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  • Official Full Name
  • argonaute RISC catalytic component 2
  • Background
  • This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • Synonyms
  • AGO2; argonaute RISC catalytic component 2; Q10; EIF2C2; protein argonaute-2; PPD; hAgo2; eIF2C 2; eIF-2C 2; argonaute2; argonaute 2; protein slicer; PAZ Piwi domain protein; eukaryotic translation initiation factor 2C, 2;
Cat.#:AGO2-1728HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human AGO2 Protein (517-818 aa), His-tagged
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Cat.#:AGO2-526HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGO2 Protein, MYC/DDK-tagged
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Cat.#:AGO2-2180HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AGO2, His tagged
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Cat.#:EIF2C2-2180HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human EIF2C2, His-tagged
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Cat.#:AGO2-8477ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGO2
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Cat.#:AGO2-714HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AGO2 cell lysate
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Cat.#:AGO2-576MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse AGO2 cell lysate
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Involved Pathway

AGO2 involved in several pathways and played different roles in them. We selected most pathways AGO2 participated on our site, such as Adaptive Immune System, Beta-catenin independent WNT signaling, Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
DYNC1H1; GM11711; FGF20A; SIGLEC12; GRAP2B; SPTBN2; UBE2V1; PAG1; AHCYL1; CTLA4
Beta-catenin independent WNT signaling
RYK; DVL1; AP2B1; MOV10; ITPR2; DVL2; AGO3; ROR2; AP2A1; AGO2
Ca2+ pathway
GNB5; AGO3; AGO1; MOV10; AGO2
DAP12 interactions
AGO2; FGF10B; PRKAR1AA; GRAP2B; RASGEF1A; MOV10; SPNA2; FRS2; SPRED1; FRS3
DAP12 signaling
DUSP1; PTPRA; DUSP6; PRKAR1AA; JAK1; PHB; SPTB; CSF2RB; WDR83; RASGRP4
Downstream signal transduction
IL17RD; FGFR1B; THEM4; PEA15A; PTPRA; SPNA1; CRKL; JAK1; PAQR3B; FRS2A
Downstream signaling events of B Cell Receptor (BCR)
AGO2
Downstream signaling of activated FGFR1
AGO2; SPRED2; PHB; PEA15; KBTBD7; SPRED3; IL17RD; WDR83; SPNA1; PAQR3A

Protein Function

AGO2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding, RNA polymerase II core binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGO2 itself. We selected most functions AGO2 had, and list some proteins which have the same functions with AGO2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA 7-methylguanosine cap binding
Related Protein DCPS; NCBP2; AGO2; EIF4EA
Function RNA polymerase II core binding
Related Protein PCF11; PAF1; SMYD2; WAC; SMYD3; SMYD2A; AGO1; CTR9; SMYD2B; ZNF326
Function core promoter binding
Related Protein EZH2; E2F7; GTF2B; SAFB; KDM3A; CCAR1; PSPC1; INSM1B; DHX36; MTA1
Function double-stranded RNA binding
Related Protein RNASEN; VIM; TLR8; DICER1; ADARB1; HMGB1; MYH4; LRRFIP1; RFTN1; CLTC
Function endoribonuclease activity
Related Protein RNASEKA; CPSF3; DICER1; DROSHA; RCL1; PLD6; TSNAX; TSN; SMG6; NOB1
Function endoribonuclease activity, cleaving miRNA-paired mRNA
Related Protein AGO2
Function endoribonuclease activity, cleaving siRNA-paired mRNA
Related Protein AGO2
Function mRNA binding
Related Protein C1QBP; ELAVL1; PIWIL2; KHSRP; ZFP36L1; DOM3Z; CELF4; HNRNPAB; XPO5; PCBP1
Function metal ion binding
Related Protein PGCP; TAX1BP1B; BA1; CYB5R4; ZHX3; ITGA4; ACAP1; PDE7A; ZNF192; ME3
Function miRNA binding
Related Protein TARBP2; TRIM71; POU5F1; AGO3; AGO1; AGO4; DICER1; SOX2; AGO2; PNPT1
Function poly(A) RNA binding
Related Protein TPR; SMNDC1; PRPF3; SLIRP; SR140; RPS27.2; QKI; SNRNP40; YTHDF2; TRIM56
Function protein C-terminus binding
Related Protein PEX12; NCL; VAMP2; PPP2CA; HIC2; PEX26; EFHC1; PRDX3; ABL1; XRCC6
Function protein binding
Related Protein BAG3; CD79B; FER; GNB2L1; ASAP2; CDK18; TTC23L; LBX1; SERPINA1; HSF1
Function siRNA binding
Related Protein MECP2; DICER1; TARBP2; AGO2; TLR7; TLR9
Function contributes_to siRNA binding
Related Protein AGO2
Function single-stranded RNA binding
Related Protein EIF2C3; POLR2GL; TLR7; STRBP; DDX58; LUZP4; AGO1; DLX2; CBX4; ZFP36
Function translation initiation factor activity
Related Protein EIF1; EIF4E1C; EIF2S3Y; EIF4E3; EIF2A; EIF3S6IP; EIF4G1; AGO2; DHX29; GTPBP1

Interacting Protein

AGO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGO2.
DICER1; TNRC6B

AGO2 Related Articles

Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).
Bukong, TN; Momen-Heravi, F; et al. Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90. PLOS PATHOGENS 10:-(2014).