ahcy
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  • Official Full Name
  • adenosylhomocysteinase
  • Background
  • S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • AHCY; adenosylhomocysteinase; S adenosylhomocysteine hydrolase; SAHH; adoHcyase; S-adenosylhomocysteine hydrolase; S-adenosyl-L-homocysteine hydrolase
Cat.#:AHCY-519HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AHCY Protein, MYC/DDK-tagged
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Cat.#:AHCY-2HTag:
Source (Host):Species:Human
Product nameRecombinant Human S-adenosyl-L-homocysteine hydrolase
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Cat.#:AHCY-31342THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AHCY, His-tagged
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Cat.#:AHCY-360HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human AHCY
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Cat.#:AHCY-418HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Adenosylhomocysteinase, GST-tagged
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Cat.#:AHCY-455HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AHCY Protein, GST-tagged
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Cat.#:AHCY-727HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Adenosylhomocysteinase, His-tagged
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Cat.#:AHCY-1439MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AHCY Protein
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Cat.#:Ahcy-3166MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Ahcy, His-tagged
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Cat.#:AHCY-571RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AHCY Protein
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Cat.#:AHCY-285CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus AHCY Protein, His-tagged
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Cat.#:AHCY-9902ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AHCY
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Cat.#:AHCY-8964HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AHCY 293 Cell Lysate
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Cat.#:Kit-2151Tag:
Source (Host):Species:
Product nameAHCY Inhibitor Screening Kit
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Cat.#:Kit-2302Tag:
Source (Host):Species:
Product nameAdenosylhomocysteinase (AHCY) Activity Fluorometric Assay Kit
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Involved Pathway

AHCY involved in several pathways and played different roles in them. We selected most pathways AHCY participated on our site, such as Biological oxidations, Cysteine and methionine metabolism, Folate Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AHCY were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Biological oxidations
ADH1C; CYP2J2; FDXR; CYP11B1; CYP2AD2; GSTK1; SULT2ST1; CYP2K18; UGT1B5; ACY3.1
Cysteine and methionine metabolism
ENOPH1; SMS; DNMT3AA; CBSB; GSS; BCAT1; APIP; GOT2; CBS; BHMT
Folate Metabolism
SAA2-SAA4; AHCY; SAA2; SAA1; ABCA1; SAA4
Metabolic pathways
P4HA1B; NADKB; DUT; CBR3; PKLR; HPDA; TPH1B; GATC; NT5M; FOLH1
Metabolism
KCNB1; MARCKSA; TYMP; MED8; ARV1; CYP4F12; PAOX; DHCR7; ATP5S; AQP1A.1
Metabolism of amino acids and derivatives
ACMSD; SLC25A15; UROC1; AZIN1A; AZIN1B; PAOX; SLC25A15A; SLC25A21; ALDH9A1A.2; IDO2
Methylation
AS3MT; AHCY; TPMT.2
One Carbon Metabolism
MTHFS; MTFMT; MTHFD2; AHCY; FTCD; ST20-MTHFS; ALDH1L1

Protein Function

AHCY has several biochemical functions, for example, NAD binding, adenosylhomocysteinase activity, adenyl nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHCY itself. We selected most functions AHCY had, and list some proteins which have the same functions with AHCY. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein BDH2; ADH4; MDH1; IDH1; TESCA; ME1; HPGD; IDH3G; HSD3B4; GPD1
Function adenosylhomocysteinase activity
Related Protein AHCY
Function adenyl nucleotide binding
Related Protein AHCY
Function identical protein binding
Related Protein TYROBP; PDCD6; RAD51; CLDN9; NONO; CLDN8; ALAD; SYT9; TPD52L1; CLDN1
Function protein binding
Related Protein SEC22C; SWAP70; MGRN1; KLHL38; RNF165; STAT4; PLCB4; ISOC1; ITGAX; LIPE

Interacting Protein

AHCY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHCY here. Most of them are supplied by our site. Hope this information will be useful for your research of AHCY.
ANKRD40; APPBP2; C1orf50; ORF; Kif1c; EIF1B; BCAR3; MCC; HLA-B; YWHAZ; PAK2; PINX1; TRAF6