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AKAP7

  • Official Full Name

    A kinase (PRKA) anchor protein 7

  • Overview

    This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    AKAP7; A kinase (PRKA) anchor protein 7; A-kinase anchor protein 7 isoform gamma; AKAP15; AKAP18; A kinase anchor protein 18 kD; A kinase anchor protein 7; A kinase anchor protein 7 isoform alpha; A kinase anchor protein 7 isoform beta; A kinase anchor protein 7 isoform gamma; A kinase anchor protein 7 isoforms alpha and beta; A kinase anchor protein 9 kDa; A kinase anchoring protein 18; AKAP 7; HGNC377; OTTHUMP00000040266; Protein kinase A anchoring protein 7; Protein kinase A anchoring protein 7 isoform alpha; Protein kinase A anchoring protein 7 isoform beta; Protein kinase A anchoring protein 7 isoform gamma; Protein kinase A anchoring protein 7 isoforms alpha/beta; AKAP 18; OTTHUMP00000017200; OTTHUMP00000017201; OTTHUMP00000017202; OTTHUMP00000239966; AKAP-7 isoform gamma; A-kinase anchor protein 9 kDa; A-kinase anchor protein 18 kDa; AKAP-7 isoforms alpha and beta; A-kinase anchor pr;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP7-9524H Recombinant Human AKAP7, GST-tagged E.coli GST 1-81a.a.
Human AKAP7-2395H Recombinant Human A-kinase (PRKA) Anchor Protein 7, His-tagged E.coli His
Human AKAP7-402H Recombinant Human AKAP7 Protein, GST-tagged Wheat Germ GST
Human AKAP7-8937HCL Recombinant Human AKAP7 293 Cell Lysate HEK293 N/A
Human AKAP7-8938HCL Recombinant Human AKAP7 293 Cell Lysate HEK293 N/A
Human AKAP7-101H Recombinant Human AKAP7 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human AKAP7-1351HF Recombinant Full Length Human AKAP7 Protein, GST-tagged In Vitro Cell Free System GST 81 amino acids
Human AKAP7-1068H Recombinant Human AKAP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKAP7-26524TH Recombinant Human AKAP7 N/A
Mouse Akap7-3031M Recombinant Mouse Akap7, GST-tagged E.Coli or Yeast GST 81
Mouse Akap7-1578M Recombinant Mouse Akap7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat AKAP7-593R Recombinant Rat AKAP7 Protein Mammalian Cell His
Rat AKAP7-249R-B Recombinant Rat AKAP7 Protein Pre-coupled Magnetic Beads HEK293
Rat AKAP7-249R Recombinant Rat AKAP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKAP7 involved in several pathways and played different roles in them. We selected most pathways AKAP7 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G Protein Signaling PathwaysAKAP13;AKAP8;AKAP12B;AKAP10;Akap2;GNB5B;AKAP12;Akap3;GNA13

AKAP7 has several biochemical functions, for example, nucleotide binding, protein binding, protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP7 itself. We selected most functions AKAP7 had, and list some proteins which have the same functions with AKAP7. You can find most of the proteins on our site.

Function Related Protein
nucleotide bindingMYHZ1.1;IGF2BP1;U2SURP;PRKACAA;MAP2K4A;GNA12A;C10orf28;BSK146;PABPN1L
protein bindingArid4b;ATF6;KIFAP3;SIRT2;ACTG1;HRASLS5;EFNA3;CYHR1;RHPN1
protein kinase A bindingDACT3;AKAP14;AKAP4;Akap2;AKAP5;AKAP17A;RARA;LRRK2;DACT2
protein kinase A regulatory subunit bindingAKAP5;PRKACA;AKAP1;AKAP9;ACBD3;PJA2;C2orf88;AKAP6;AKAP8
protein kinase bindingSTXBP1;PDPK1;ZC3HC1;HDAC7;CCNL1B;MAPK6;SOCS1;CD24;CAMK2N1

AKAP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP7.

  • Q&As
  • Reviews

Q&As (16)

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Can AKAP7 be used as a biomarker for any diseases? 05/16/2023

Currently, AKAP7 is not widely used as a biomarker for specific diseases. However, given its involvement in various cellular signaling pathways and disease processes, it is possible that AKAP7 or its isoforms could be utilized as biomarkers in the future. For example, changes in AKAP7 expression or phosphorylation levels in cardiac tissue could potentially be used to assess cardiac function and predict the risk of cardiac disorders. Further studies are needed to investigate the potential utility of AKAP7 as a biomarker and to establish its diagnostic and prognostic value in various diseases.

Can AKAP7 interact with other proteins? 01/06/2022

Yes, AKAP7 can interact with a variety of other proteins. One of its most well-studied interactions is with protein kinase A (PKA). AKAP7 binds to the regulatory subunit of PKA, allowing for localized and specific targeting of PKA to certain cellular compartments or substrates. This interaction is crucial for the proper phosphorylation of PKA substrates and the regulation of various signaling pathways.

Are there any genetic disorders associated with AKAP7? 10/05/2020

To date, there have been no genetic disorders directly linked to AKAP7 mutations. However, dysregulation of AKAP7 and its interaction with other signaling molecules have been implicated in various cardiovascular disorders, such as arrhythmias, heart failure, and hypertrophy. Additionally, alterations in AKAP7 expression or function have been observed in neurological and psychiatric disorders, including schizophrenia and bipolar disorder. Although more research is needed to fully understand the genetic factors contributing to these disorders, AKAP7 represents a potential target for future therapeutic interventions.

What are the implications of AKAP7 in cardiac function? 09/13/2020

AKAP7 is particularly important for regulating cardiac function. It plays a crucial role in controlling heart rate and contractility by anchoring PKA and other signaling molecules to specific locations within cardiac cells. AKAP7 helps facilitate the phosphorylation of ion channels and other proteins involved in cardiac electrical conduction, calcium handling, and contractile function. Dysregulation of AKAP7 and its interaction with PKA can lead to cardiac arrhythmias, hypertrophy, and other cardiovascular disorders.

How is AKAP7 protein regulated? 06/30/2020

The activity and localization of AKAP7 protein can be regulated through various mechanisms. One primary regulatory mechanism involves protein phosphorylation. AKAP7 itself can be phosphorylated by protein kinases, such as PKA, which can modulate its function and interactions with other proteins. Additionally, AKAP7 can interact with other regulatory proteins and signaling molecules, such as anchoring proteins and phosphatases, which can influence its activity and localization.

Are there any ongoing studies investigating AKAP7 and its implications in diseases? 02/23/2020

Yes, there are ongoing studies investigating the role of AKAP7 in various diseases. Researchers are exploring the specific mechanisms by which AKAP7 influences cellular function, signaling pathways, and disease processes. Some studies focus on understanding the involvement of AKAP7 in cardiac disorders, while others aim to determine its contribution to neurological and psychiatric disorders. These studies may provide valuable insights into the potential therapeutic targets and strategies for these diseases.

Is there any evidence for polymorphisms or mutations in the AKAP7 gene? 03/31/2019

Polymorphisms and mutations in the AKAP7 gene have been reported in some studies. For example, a study analyzing genetic variations in AKAP7 identified several single nucleotide polymorphisms (SNPs) in the gene. These SNPs were found to be associated with increased risk of atrial fibrillation, a common heart rhythm disorder.

Are there different isoforms of AKAP7? 03/23/2019

Yes, there are multiple isoforms of AKAP7 that are derived from alternative splicing of the AKAP7 gene. The main isoforms include AKAP7α (also known as AKAP15α) and AKAP7γ (also known as AKAP15γ or AKAP18β). These isoforms have different tissue-specific expression patterns and may have distinct roles in different cellular contexts.

How can AKAP7 impact neuronal function? 03/22/2019

AKAP7 is expressed in the brain and has been shown to play a role in neuronal function and synaptic plasticity. It interacts with signaling proteins, including protein kinases and phosphatases, to regulate the phosphorylation status of key proteins involved in neurotransmission and synaptic activity. AKAP7 has been implicated in the modulation of synaptic strength, long-term potentiation (LTP), and learning and memory processes. Dysregulation of AKAP7-mediated signaling pathways in the brain has been associated with neurological disorders, such as schizophrenia and mood disorders.

Can genetic variations in AKAP7 contribute to diseases? 06/03/2017

Genetic variations in AKAP7 have been associated with certain diseases. For example, variations in the AKAP7 gene have been linked to an increased risk of cardiovascular diseases, such as hypertension and heart failure. Additionally, alterations in AKAP7 expression and function have been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, as well as psychiatric disorders like schizophrenia. However, more research is needed to fully understand the role of AKAP7 genetic variations in these diseases and how they contribute to their pathogenesis.

What are the specific isoforms of AKAP7? 03/23/2016

AKAP7 has several known isoforms that vary in their expression patterns and functions. The two major isoforms of AKAP7 are AKAP7α and AKAP7β. AKAP7α is predominantly expressed in cardiac and skeletal muscle tissues and plays a crucial role in regulating cardiac function. AKAP7β, on the other hand, is expressed in a variety of tissues, including the brain, adrenal glands, and smooth muscle, and is involved in signaling pathways related to neurotransmission and smooth muscle contraction. These isoforms have different protein structures and functional properties, allowing for specific regulation of different cellular processes.

Are there any diseases or disorders associated with aberrant AKAP7 expression or function? 12/10/2015

Yes, AKAP7 dysregulation has been implicated in several diseases and disorders. One example is cardiac hypertrophy, as mentioned earlier. Dysregulation of AKAP7α expression or its interaction with signaling molecules has been shown to contribute to the development of cardiac hypertrophy.

Are there any drugs or therapies targeting AKAP7? 11/25/2015

Currently, there are no drugs or therapies specifically targeting AKAP7. However, because of its essential role in cellular signaling and its association with various diseases, AKAP7 is an attractive target for future drug development. Researchers are investigating strategies to modulate AKAP7 function, such as interfering with its protein-protein interactions or developing small molecules that can selectively target AKAP7-related signaling pathways. These approaches may have therapeutic potential for the treatment of cardiovascular, neurological, and psychiatric disorders.

Are there any therapeutic implications for AKAP7? 10/17/2015

The involvement of AKAP7 in various cellular processes and disease pathways suggests that it could serve as a potential therapeutic target. For example, targeting specific isoforms of AKAP7, such as AKAP7α in cardiac-related disorders or AKAP7β in neurological disorders, could potentially modulate the aberrant signaling pathways associated with these conditions.

Is AKAP7 involved in cardiac hypertrophy? 08/06/2015

Yes, AKAP7 has been implicated in the regulation of cardiac hypertrophy. Cardiac hypertrophy refers to the enlargement and thickening of the heart muscle in response to stress or increased workload. AKAP7α, specifically, has been shown to play a role in the development of cardiac hypertrophy.

Is AKAP7 exclusively found in humans? 07/01/2015

No, AKAP7 is not exclusively found in humans. This protein is evolutionarily conserved and has been identified in various species, including mice, rats, and other mammals. Studies using animal models have provided valuable insights into AKAP7 function and its implications in disease. Although there may be some differences in isoforms and expression patterns between species, the fundamental role of AKAP7 in regulating cellular signaling is believed to be conserved across different organisms.

Customer Reviews (4)

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Reviews
08/08/2020

    AKAP7 protein offers an outstanding level of technical support, which is crucial for overcoming any challenges that may arise during my experiments.

    11/13/2019

      Its superior composition guarantees accuracy, reliability, and reproducibility, ensuring precise and consistent results in my research endeavors.

      10/22/2018

        The AKAP7 protein is undoubtedly a cornerstone of my experimental design, poised to meet and exceed my every need.

        10/18/2015

          The AKAP7 protein epitomizes the highest standards of quality, possessing exceptional purity and functionality that perfectly aligns with my experimental goals.

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