akt2
Share
  • Official Full Name
  • v-akt murine thymoma viral oncogene homolog 2
  • Background
  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
  • Synonyms
  • Akt2; AKT2_HUMAN; PKB; PKB beta; PKBBETA; PRKBBy; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; RAC BETA; RAC beta serine threonine protein kinase; RAC PK beta; Rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; RACbeta; V AKT Murine Thymoma Viral Oncogene Homolog 2
Cat.#:AKT2-163HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, Active, His-tagged
+Inquiry
Cat.#:AKT2-102HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged, Active
+Inquiry
Cat.#:AKT2-103HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged, Active
+Inquiry
Cat.#:AKT2-1841HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT2 protein, His & T7-tagged
+Inquiry
Cat.#:AKT2-248HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT2 Protein, His & GST-tagged
+Inquiry
Cat.#:AKT2-31HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT2 protein, Flag-tagged, Biotinylated
+Inquiry
Cat.#:AKT2-424HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT2 Protein, GST-His tagged
+Inquiry
Cat.#:AKT2-802HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged
+Inquiry
Cat.#:AKT2-606RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT2 Protein
+Inquiry
Cat.#:AKT2-297RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT2 Protein, His-tagged
+Inquiry
Cat.#:AKT2-9802ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT2
+Inquiry
Cat.#:AKT2-1364HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2 (Active), His-tagged
+Inquiry
Cat.#:AKT2-165HTag:His
Source (Host):Species:Human
Product nameRecombinant Human AKT2, His-tagged
+Inquiry
Cat.#:AKT2-166HTag:His
Source (Host):Species:Human
Product nameRecombinant Human AKT2, His-tagged
+Inquiry
Cat.#:AKT2-985HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged
+Inquiry
Cat.#:AKT2-8927HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKT2 293 Cell Lysate
+Inquiry

Involved Pathway

AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PPM1BB; RPS6KA3B; MKNK2B; PLA2G4D; NR4A1; FGF13B; RAF1B; TAOK2; FGF20; MAP4K4
ErbB signaling pathway
MAP2K4B; MAP2K2A; GSK3B; SOS1; AKT1; PLCG1; AKT2; PRKCG; MAPK9; SHC2
Ras signaling pathway
MAPK10; PDGFD; RASA1; FGF5; ANGPT1; FGF3; NF1; PRKCG; GNB2; GNG12
Rap signaling pathway
SIPA1L2; FGFR2; INS2; PRKCG; LPAR3; MLLT4; TEK; ITGB3; SRC; CALML5
cGMP-PKG signaling pathway
RHOA; ATP1B3; FXYD2; ATP2A3; GTF2IRD1; PLCB4; NOS3; CALM1; ROCK1; NFATC4
cAMP signaling pathway
PIK3R1; HCN2; CNGA4; GPR81; GRIN3A; GLP1R; HTR4; MAPK1; CAMK4; HTR1E
Chemokine signaling pathway
CCL4L2; SOS1; CXCR2; NCF1; RAP1A; NFKBIA; PLCB1; CCL21; GNGT1; AKT2
HIF- signaling pathway
CUL2; NOS3; INS2; CAMK2D; ANGPT4; IFNG; VEGFA; Il6ra; INS; TFRC
FoxO signaling pathway
Fasl; IGF1RB; SIRT1; PIK3R3A; MAP2K2B; CDKN2D; STAT3; AGAP2; BNIP4; KRAS
Sphingolipid signaling pathway
S1PR4; PPP2CA; SGMS1; MAPK10; NFKB1; MAPK1; PPP2R5D; PPP2R2B; PLCB2; TRP53
Phospholipase D signaling pathway
PTK2B; GRB2; TSC2; TSC1; CYTH2; PLD2; PTGFR; PIK3R3; RRAS; AGPAT3
mTOR signaling pathway
VEGFAA; AKT3A; RRN3; PRKCG; RPS6KA3A; PRKCBB; PIK3CD; AKT2L; RPS6KA6; RPS6KA2
PIK-Akt signaling pathway
SGK3; PPP2R5D; GSK3B; GNGT2; PRKAA2; FGF10; YWHAG; EPO; GNB2; GNG12
AMPK signaling pathway
TSC2; CREB3L3; LEPR; HMGCR; PIK3CB; PDPK1; INS2; TBC1D1; PIK3CA; PRKAG2
Apoptosis
DSP; PIK3R1; JUN; CFLARA; BOKA; PRKAR2A; BIDA; IRF4A; CTNNB2; STK26
Adrenergic signaling in cardiomyocytes
CACNB3A; ADRA1B; MAPK3; PRKACA; CALM3B; PPP2R2D; ATP1B1A; PRKCA; MYH15; ATF4
VEGF signaling pathway
RAC3B; PTK2AB; MAPK11; PPP3CC; SHC2; SRC; PIK3CG; MAP2K1; AKT2L; RAC2
Osteoclast differentiation
SIRP-BETA; CYLD; TGFBR2; IFNAR2; FOSL1; TNFRSF1A; TRAF2; GRB2; TREM2; CSF1
Focal adhesion
MYL2B; AASS; PAK3; MAPK3; VTN; PAK7; FLT1; ITGB1; PIK3R3B; ITGA2
Tight junction
CSDA; MAGI3; MYHZ1.1; CLDN10A; SHROOM3; MYH13; CLDNC; MYHC4; YES1; ACTN3
Signaling pathways regulating pluripotency of stem cells
NEUROG1; WNT9A; ACVR2B; SMARCAD1; ACVR1C; MAP2K1; SMAD3; FGFR1; PCGF1; STAT3
Platelet activation
MAPK1; MAPK13; F2R; ITPR1; PPP1CB; PIK3R5; PLCB3; MYLK; PRKCZ; TBXAS1
Toll-like receptor signaling pathway
MAP2K4B; TLR2-1; TICAM2; IL8L2; CCL4; MAPK13; IL12B; IFNA14; MYD88; CCL3L1
Jak-STAT signaling pathway
PTPN11; IL4R; SOCS3B; IFNA13; IL-15RA; SOCS6; RAF1B; IL13; IL2RA; PIAS2
T cell receptor signaling pathway
NFKBIA; CD3E; CD3D; BCL10; PPP3CA; NFKB1; PDPK1; DBNLB; NCK1; IL5; IFNG
B cell receptor signaling pathway
LILRB3; CDK4; CTNNB2; PIK3R3; CD79B; VAV1; CMTM3; PPP3R1; KRAS; CD81
Fc epsilon RI signaling pathway
FCER1G; MAP2K7; LYN; IL13; MAP2K2; PIK3CD; RAC3; MAP2K6; GM-CSF; PLA2G4F
Fc gamma R-mediated phagocytosis
GAB2; PLD2; WASL; PRKCE; SCIN; PLCG1; PPAP2A; PIK3R2; WAS; RAC2
TNF signaling pathway
PIK3R1; MMP9; ICAM1; CCL2; CCL20; MAP3K14; IKBKG; FADD; PIK3CD; IL15
Neurotrophin signaling pathway
CALM1; GAB1; RPS6KA6; MAPK7; ATF4; SHC3; MAPK3; CAMK2G; MAP2K5; SOS1
Cholinergic synapse
CHRM3; GNG13; KCNJ12; PIK3CG; CAMK2G; JAK2; CHRNA3; PRKCB; GNB4; CHRNA7
Dopaminergic synapse
CALY; PPP3CB; KCNJ5; PRKACA; CALML5; PPP2R3C; CALM4; CLOCK; PPP3CA; GNG3
Insulin signaling pathway
PPP1CBL; PPP1R3C; PRKAB2; IRS4; PRKCI; INSRA; CBLC; PRKACG; CALM2B; PHKG1
Progesterone-mediated oocyte maturation
CDC23; GNAI2B; PIK3CA; PLK1; CDC27; INS1; IGF1; CPEB1B; CDC26; PRKACB
Estrogen signaling pathway
NOS3; NRAS; PLCB1; GRB2; GNAO1; ESR2; GNAS; CALM2; HSPA1A; MAP2K1
Prolactin signaling pathway
PRLR; SIRPA; AKT2; STAT5A; SOCS2; SOCS3; PIK3R2; PIK3R1; MAPK1; MAPK13
Thyroid hormone signaling pathway
PLCZ1; PLCD4; TP53; THRA; PFKP; KAT2B; PLCB1; THRB; MED14; MED24
Adipocytokine signaling pathway
SLC2A4; PRKAA2; IRS2; AKT3A; ACSL1; TNFRSF1B; LEPA; ACSL4A; ACSL3A; ACSBG1
Glucagon signaling pathway
ATF4; PLCB1; ACACB; PFKFB1; PPP3CC; PCK1; PLCB2; PRKAA2; PLCB3; AKT1
Regulation of lipolysis in adipocytes
PTGER3; IRS4; PIK3CD; IRS2; TSHB; Adcy4; PLIN1; PRKG1; GNAI3; NPY1R
Insulin resistance
PPARGC1B; PTENB; PPARAB; PYGM; PRKCBB; PDPK1B; PIK3CB; FOXO1A; SLC2A2; RELA
Non-alcoholic fatty liver disease (NAFLD)
EIF2AK3; PPARA; ERN1; NDUFA2; MAPK10; CASP8; MAPK8; ITCH; COX5A; COX7A1
Carbohydrate digestion and absorption
PRKCB; SLC37A4; SLC5A1; HK1; AMY1B; HK3; TAS1R3; G6PC; SLC2A5; PIK3CA
Chagas disease (American trypanosomiasis)
TNF; CCL3L1; C3; PIK3R5; PIK3CA; PLCB2; TGFB3; GNAI3; PIK3R3; PPP2R1B
Toxoplasmosis
STAT3; TNFRSF1A; H2-AA; CD40; IRGM1; ITGB1; HLA-DOA; IL12B; MAPK10; HLA-DRB3
Tuberculosis
MAPK10; IFNA21; RIPK2; NFYA; NFYB; IFNA8; CD209C; RFXAP; APAF1; BID
Hepatitis C
CLDN7; IFNA2; CLDN9; BAD; PDPK1; OSTN; CLDN11; IFNAR2; STAT2; TNF
Hepatitis B
RELA; EGR3; Ifna15; IFNA12; IKBKE; SMAD4; DDX3X; TICAM2; EGR2; PTK2B
Measles
STAT3; IFNA21; CD28; TNFRSF10B; FAS; STAT2; TLR2; AKT2; IFNA8; TNFRSF10C
Influenza A
RELA; LOC100686744; NFKB1; HLA-DPB1; IVNS1ABP; IFNA10; MAP2K2; HSPA1A; IFNA7; PIK3CA
HTLV-I infection
IKBKG; WNT4; NFATC4; FZD7; CRTC3; GPS2; POLD2; FDPS; SLC25A4; TBPL2
Epstein-Barr virus infection
PRKACB; HLA-DRA; POLR3F; STAT3; CSNK2B; TRAF5; IL10RA; PSMC2; HLA-DRB3; TYK2
Pathways in cancer
RALGDS; HGF; TRAF1; LAMB4; TFG; PTGER1; WNT11; PTGER4; PDGFRB; CBL
Proteoglycans in cancer
TRP53; MDM2; HCLS1; ERBB3; PPP1R12A; PRKCG; PRKCA; RDX; ITPR1; IGF2
Colorectal cancer
AKT1; AXIN2; RAC1; RAC2; SMAD2; MSH6; BIRC5; PIK3R5; MAP2K1; Casp3
Renal cell carcinoma
EGLN1; GRB2; RAC1; GAB1; PAK6; SOS1; PIK3CA; PAK3; RAP1B; TGFB1
Pancreatic cancer
BCL2L1; IKBKB; STAT1; RAC1; IKBKG; TGFB2; PIK3CB; RB1; MAPK8; BRCA2
Endometrial cancer
ARAF; FOXO3; AKT2; TCF7L2; CASP9; SOS1; PIK3R1; BAD; MAP2K2; HRAS
Glioma
CALM2; PLCG1; PIK3CD; MAP2K1; PDGFA; CALM4; PIK3R5; MAP2K2; CALM1; SOS1
Prostate cancer
ERBB2; IKBKB; PIK3CB; TCF7; NFKB1; MAPK3; PIK3R5; CASP9; MAPK1; Ar
Melanoma
MET; PIK3R1; BRAF; FGF7; FGF12; IGF1; FGF19; RB1; MAPK1; FGF14
Chronic myeloid leukemia
NRAS; PIK3CB; CRKL; SHC3; MAPK3; PIK3CD; MAP2K1; BCR; KRAS; IKBKG
Acute myeloid leukemia
STAT5A; STAT3; PPARD; PIK3CB; KRAS; NRAS; PIM2; PIM1; PIK3R3; BRAF
Small cell lung cancer
IKBKG; RXRA; PIK3R3; TRP53; NFKBIA; PIK3CD; XIAP; LAMA1; PTGS2; ITGA6
Non-small cell lung cancer
ERBB2; CASP9; MAP2K1; PIK3CA; PLCG2; PRKCB; RB1; PIK3R2; RXRA; RAF1
Central carbon metabolism in cancer
PDK1; SLC16A3; HKDC1; PGAM1; HK1; C12orf5; FLT3; PDHA2; IDH1; PDGFRB
Choline metabolism in cancer
MAPK8; AKT1; PIK3R5; PRKCB; RAC1; PLD2; PDPK1; PLA2G4A; RALGDS; RAC2

Protein Function

AKT2 has several biochemical functions, for example, ATP binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2J2; GRK1; GK2; TTK; RYK; HSPA2; PIP4K2C; ADCK2; STK30; DYNC1LI2
Function protein binding
Related Protein VCAN; OSBPL6; TUBB; KLHDC5; ATG5; GPR19; PTGFRN; NRXN1; EHD4; ANGPT1
Function protein kinase C binding
Related Protein AVPR1B; NELL2; IRS1; GNB2L1; DACT2; DACT3; HSPB1; CASQ2; GRK5; FEZ1
Function protein serine/threonine kinase activity
Related Protein LATS2; PBK; STK32B; PIK3CG; RPS6KA5; CDKL5; TESK1; RIOK2; PAK3; CAMK2D

Interacting Protein

AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.
HSP90AB1; crosstide; CASP3; GSK3B; LRRK2; SH3RF1; MYH13; VIM; SETDB1; CDC37; SORBS2; APOA1; APOB

AKT2 Related Articles

van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

AKT2 Related Gene Family

TGF