akt2
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  • Official Full Name
  • v-akt murine thymoma viral oncogene homolog 2
  • Background
  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
  • Synonyms
  • Akt2; AKT2_HUMAN; PKB; PKB beta; PKBBETA; PRKBBy; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; RAC BETA; RAC beta serine threonine protein kinase; RAC PK beta; Rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; RACbeta; V AKT Murine Thymoma Viral Oncogene Homolog 2
Cat.#:AKT2-163HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, Active, His-tagged
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Cat.#:AKT2-102HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged, Active
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Cat.#:AKT2-103HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged, Active
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Cat.#:AKT2-1841HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT2 protein, His & T7-tagged
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Cat.#:AKT2-248HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT2 Protein, His & GST-tagged
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Cat.#:AKT2-31HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT2 protein, Flag-tagged, Biotinylated
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Cat.#:AKT2-424HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT2 Protein, GST-His tagged
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Cat.#:AKT2-802HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged
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Cat.#:AKT2-606RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT2 Protein
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Cat.#:AKT2-297RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT2 Protein, His-tagged
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Cat.#:AKT2-9802ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT2
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Cat.#:AKT2-1364HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2 (Active), His-tagged
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Cat.#:AKT2-165HTag:His
Source (Host):Species:Human
Product nameRecombinant Human AKT2, His-tagged
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Cat.#:AKT2-166HTag:His
Source (Host):Species:Human
Product nameRecombinant Human AKT2, His-tagged
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Cat.#:AKT2-985HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged
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Cat.#:AKT2-8927HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKT2 293 Cell Lysate
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Involved Pathway

AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAX; MAP2K4; HRASA; RPS6KA1; RPS6KA5; IKBKB; FGF16; MEF2CB; PLA2G4D; FGF1A
ErbB signaling pathway
BAD; RPS6KB1B; GSK3AA; RAF1A; AKT3A; EREG; MAPK8A; PIK3R2; CAMK2D1; HBEGFA
Ras signaling pathway
RALGDS; VEGFA; PAK3; HRAS; GRIN2B; GAB2; PLCG1; PIK3CB; GNB3; FGF22
Rap signaling pathway
PLCB1; PLCB4; RAP1GAP; FGF13; PARD6B; KRAS; PLCG1; MAPK3; GNAI2; DOCK4
cGMP-PKG signaling pathway
SRF; PRKG1; GNAQ; PLN; BAD; PLCB1; KCNJ8; NFATC2; CALM3; SLC25A6
cAMP signaling pathway
CNGA4; AMH; GRIN3B; MAPK8; GRIA3; GLP1R; HTR1E; GIPR; GRIN2B; HCN4
Chemokine signaling pathway
GNGT1; Ccl9; CXCL11; PRKCZ; CCL3L1; CCL11; CCR8; CDC42; CRK; CCR9
HIF- signaling pathway
PRKCG; CAMK2D; NOS2; GM5506; MTOR; PGK1; ALDOA; INS; CAMK2B; MAP2K2
FoxO signaling pathway
BCL6A; FBXO25; IGF1R; GABARAPL2; TGFBR2; CDKN1BB; CCNB2; PIK3R3A; INSRB; HRASB
Sphingolipid signaling pathway
CERS4; NFKB1; LASS2; PRKCG; PIK3CD; GNAI1; RAC1; PDPK1; TNF; PPP2R5B
Phospholipase D signaling pathway
Kitl; RAF1; LPAR6; PDGFD; PLA2G4C; MAP2K2; AVPR2; PLCB3; PIP5K1C; AVPR1B
mTOR signaling pathway
EIF4EA; RRAGC; ULK1; HIF1A; INS; RICTOR; RPS6KB2; AKT2; VEGFAA; AKT2L
PIK-Akt signaling pathway
ITGB3; KIT; IFNA2; EPOR; PIK3R2; PPP2R1A; PIK3R5; TNC; ITGA6; PRKAA1
AMPK signaling pathway
PPP2R2C; CREB5; PFKFB1; PRKAG1; Scd1; FBP2; MAP3K7; RAB8A; LIPE; Scd2
Apoptosis
HRK; TNFSF10; BAXA; CASP2; IRF4A; DIABLOA; IRF4; PPP3CCB; BIRC2; DAPK1
Adrenergic signaling in cardiomyocytes
PIK3R3; ATP1A2; GNAQ; ADCY8; ADRA1BB; GNA15.4; AGTR1B; CACNA1SB; PIK3CA; MYL3
VEGF signaling pathway
VEGFAB; RAC1; RAF1B; PPP3CCA; CDC42; PTGS2B; RAF1; VEGFAA; NRAS; PIK3R3A
Osteoclast differentiation
FCGR3; CYLD; RELB; FHL2; IFNGR1; FOSL2; TNF; NOX3; SPI1; LILRB1
Focal adhesion
Reln; TNXB; PARVA; ROCK1; PDGFA; ACTN2B; ITGB3; BIRC3; ITGA11A; ITGA4
Tight junction
ACTN2B; PRKCD; ACTN3A; TJAP1; JAM3B; EXOC4; CLDN17; CLDN22; PPP2CA; SHROOM2
Signaling pathways regulating pluripotency of stem cells
WNT16; ESX1; FZD7; FZD9; FZD5; BMI1; ACVR1C; KRAS; PCGF5; IGF1R
Platelet activation
RHOA; SNAP23; FGA; PRKACB; ORAI1; PPP1CB; ITPR3; PLA2G4D; GP1BA; ACTG1
Toll-like receptor signaling pathway
IFNA2; IRAK4; MAP2K2B; TLR4BA; IL12B; AKT1; MAPK3; IFNAR1; Ifna11; MAPK10
Jak-STAT signaling pathway
FHL1A; SOCS3B; CNTF; HRASB; IL3RA; AOX2P; IL2RG; PTPN6; PIK3CB; LIF
T cell receptor signaling pathway
LCK; CBL; MAPK3; MAPK13; PPP3R1; CBLC; CD40LG; PTPN6; TEC; LCP2
B cell receptor signaling pathway
PPP3CB; PPP3R2; ARPC5; Cd79a, Cd79b; MAPK1; SOS1; ACTR2; CDK7; AKT1; BLK
Fc epsilon RI signaling pathway
MAP2K4; IL5; RAC2; PIK3CB; MAP2K1; MAP2K3; NRAS; LAT; VAV3; MAP2K2
Fc gamma R-mediated phagocytosis
PLA2G4F; WASF1; SPHK1; PIK3R5; MARCKS; PRKCG; AKT1; ASAP3; MYO10; PLA2G4D
TNF signaling pathway
MAPK10; FOS; MAP2K7; CXCL2; MAP2K1; MAPK11; MAP2K3; MAP3K14; ATF4; NFKB1
Neurotrophin signaling pathway
MAPK1; RPS6KA3; RAF1; NTF4; TRAF6; Fasl; PIK3CD; PTPN11; PRKCD; ZFP110
Cholinergic synapse
PRKCG; KCNJ3; AKT1; CREB3L2; PRKACG; KCNQ1; KCNJ12; GNAI2; CHRM2; GNG11
Dopaminergic synapse
GRIA1; MAPK13; CAMK2G; PPP2R5A; GNB1; PPP2R5B; ITPR3; FOS; GNG11; PRKACA
Insulin signaling pathway
PPP1CAA; TSC1B; MAPK8; MKNK2B; SHC2; PTPRF; MAPK8A; CALM2; PYGL; ACACA
Progesterone-mediated oocyte maturation
PIK3R5; PIK3CA; ADCY2B; HSP90AB1; PKMYT1; CCNB1; CDC25C; GNAIA; ANAPC4; PIK3CD
Estrogen signaling pathway
CREB5; SHC4; FKBP4; AKT2; PLCB3; GNAI3; PIK3CA; SP1; PIK3R1; KCNJ9
Prolactin signaling pathway
SOCS6; STAT5B; SHC3; SOCS7; CCND2; RELA; ESR1; PIK3CB; STAT1; FOS
Thyroid hormone signaling pathway
PFKP; PRKACG; NCOR1; AKT2; RAF1; TP53; ATP1A3; MTOR; MED14; SLC16A10
Adipocytokine signaling pathway
G6PC3; SLC2A1; PTPN11; CPT1C; RXRA; ACACB; PRKAG2A; ADIPOQB; RXRG; PPARGC1A
Glucagon signaling pathway
PRKAA2; PRKACG; CREB3L1; PRMT1; CAMK2G; PDHA2; PRKAA1; EP300; PRKAG1; SLC2A2
Regulation of lipolysis in adipocytes
NPY; PRKG2; PTGER3; INSR; LOC100328615; TSHR; GNAS; IRS4; INS1; PTGS2
Insulin resistance
PTENB; PPP1R3C; CRTC2; PRKAB1; PRKAB1B; SLC27A3; PRKCB; G6PC; PRKAG3B; GYS2
Non-alcoholic fatty liver disease (NAFLD)
CYCS; INS; ERN1; NDUFB6; PPARA; NDUFA11; NDUFS3; LEPR; NR1H3; SDHD
Carbohydrate digestion and absorption
AMY2A2; PIK3CB; PRKCB; AKT1; ATP1A2; AMY2A4; ATP1B3; AMY2B; SLC2A5; GNAT3
Chagas disease (American trypanosomiasis)
GNAS; PIK3CB; TGFBR1; NFKB1; CXCL8; PIK3R3; TLR9; PIK3CD; IFNGR2; PIK3R5
Toxoplasmosis
HLA-DOB; BIRC7; LY96; NFKBIA; MAPK11; BIRC3; Toxoplasma Gondii Profilin Family Protein; TYK2; CD40LG; NOS2
Tuberculosis
MYD88; MAPK10; PLK3; NFYB; FADD; RELA; SPHK2; RFX5; IL12B; Ifna11
Hepatitis C
CLDN14; EIF2AK1; TNFRSF1A; SOCS3; CLDN8; TRAF3; IRF7; GSK3B; CLDN15; EIF2AK2
Hepatitis B
PIK3R5; RELA; IFNA1; MAP2K1; BAD; TBK1; FADD; EGR2; MAVS; SMAD3
Measles
HSPA2; HSPA1A; IFNA16; IFIH1; IFNG; CD28; TYK2; TLR9; IFNA4; IFNA10
Influenza A
PRSS3; EP300; VDAC1; IL6; TNFRSF10A; PRKCA; MAPK1; NFKBIB; STAT2; TLR3
HTLV-I infection
WNT6; TP53INP1; SRF; ITGAL; DVL2; SMAD4; TGFB3; HLA-DOA; PDGFA; IKBKB
Epstein-Barr virus infection
ENTPD8; FCER2; CD38; HLA-DQB1; POLR2J3; RIPK1; PSMD1; TRAF2; POLR2L; MDM2
Pathways in cancer
GNG3; VEGFA; ROCK1; IGF1R; RAD51; CASP9; RELA; WNT8A; IL-8; LAMB1
Proteoglycans in cancer
CAV3; SDC2; Fzd4; PPP1CC; CBLC; FZD5; CBL; CDC42; ERBB4; WNT7B
Colorectal cancer
PIK3R3; RAC3; TGFB2; BRAF; APPL1; MAPK8; CYCS; MLH1; TGFB3; AXIN2
Renal cell carcinoma
NRAS; HGF; RAP1A; PAK2; BRAF; MAP2K2; GRB2; TGFB3; PIK3CB; ARNT
Pancreatic cancer
TGFBR1; MAPK3; SMAD3; PIK3CD; MAPK1; RAC2; RB1; CDC42; TRP53; RELA
Endometrial cancer
AXIN2; SOS1; CCND1; PIK3CD; ELK1; AKT2; ARAF; MAP2K2; TRP53; MAPK3
Glioma
TRP53; SOS1; PIK3CG; CAMK2B; CCND1; AKT2; PDGFRA; PIK3R5; Pdgfa&Pdgfb; SHC1
Prostate cancer
INS1; RAF1; CCNE1; SMARCA4; PIK3R2; ARID1A; AKT1; MAPK1; NOXA1; ATF4
Melanoma
PIK3R3; BAD; FGF17; Pdgfa&Pdgfb; MDM2; PDGFD; PIK3R5; NRAS; FGF22; Fgf15
Chronic myeloid leukemia
IKBKB; SMAD4; RUNX1; PIK3CB; CRKL; ARAF; IKBKG; MECOM; ABL1; SHC1
Acute myeloid leukemia
RPS6KB2; MTOR; TCF7L2; PIK3CA; NFKB1; STAT3; STAT5A; HRAS; PIK3CB; MAPK1
Small cell lung cancer
APAF1; IKBKG; TP53; ITGB1; ITGAV; PIK3CA; RELA; ITGA2; SKP2; BCL2L1
Non-small cell lung cancer
FOXO3; PIK3R1; AKT2; PIK3R5; GRB2; PRKCB; RASSF5; PIK3CB; RXRB; PRKCA
Central carbon metabolism in cancer
G6PD; MTOR; FGFR2; HK1; PIK3CB; SCO2; PIK3R1; PKM2; MAP2K2; HK3
Choline metabolism in cancer
MAPK9; PIK3CB; TSC2; TSC1; CHKA; PDGFC; WASF2; EGF; PPAP2B; WASF1

Protein Function

AKT2 has several biochemical functions, for example, ATP binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TRPM6; CDC42BPB; EPHA1; IGF1RA; DHX32; ADCK3; CCC2; ATP1A2A; MYH10; CAMK2B1
Function protein binding
Related Protein WDR20; MOB3C; PITPNC1; PEPD; C10orf119; TRAPPC2L; MEA1; ARMCX5-GPRASP2; FNIP1; MRPL4
Function protein kinase C binding
Related Protein PRKCSH; NELL2; UGT1A7; PDLIM5; PKN1; CASQ2; SDPR; HDAC7; AKT1; DACT3
Function protein serine/threonine kinase activity
Related Protein DYRK1A; PRKCDA; TESK2; ERN1; NLK; SMG1; PRKACAA; ULK2; RIOK2; IRAK1

Interacting Protein

AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.
HSP90AB1; crosstide; CASP3; GSK3B; LRRK2; SH3RF1; MYH13; VIM; SETDB1; CDC37; SORBS2; APOA1; APOB

AKT2 Related Articles

van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

AKT2 Related Gene Family

TGF