akt2
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  • Official Full Name
  • v-akt murine thymoma viral oncogene homolog 2
  • Background
  • This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
  • Synonyms
  • Akt2; AKT2_HUMAN; PKB; PKB beta; PKBBETA; PRKBBy; Protein kinase Akt 2; Protein kinase Akt-2; Protein kinase B beta; RAC BETA; RAC beta serine threonine protein kinase; RAC PK beta; Rac protein kinase beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; RACbeta; V AKT Murine Thymoma Viral Oncogene Homolog 2
Cat.#:AKT2-163HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, Active, His-tagged
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Cat.#:AKT2-102HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged, Active
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Cat.#:AKT2-103HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged, Active
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Cat.#:AKT2-1841HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT2 protein, His & T7-tagged
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Cat.#:AKT2-248HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT2 Protein, His & GST-tagged
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Cat.#:AKT2-31HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human AKT2 protein, Flag-tagged, Biotinylated
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Cat.#:AKT2-424HTag:GST/His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT2 Protein, GST-His tagged
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Cat.#:AKT2-802HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2, GST-tagged
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Cat.#:AKT2-606RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT2 Protein
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Cat.#:AKT2-297RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT2 Protein, His-tagged
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Cat.#:AKT2-9802ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AKT2
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Cat.#:AKT2-1364HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT2 (Active), His-tagged
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Cat.#:AKT2-165HTag:His
Source (Host):Species:Human
Product nameRecombinant Human AKT2, His-tagged
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Cat.#:AKT2-166HTag:His
Source (Host):Species:Human
Product nameRecombinant Human AKT2, His-tagged
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Cat.#:AKT2-985HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Akt Murine Thymoma Viral Oncogene Homolog 2, His-tagged
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Cat.#:AKT2-8927HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AKT2 293 Cell Lysate
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Involved Pathway

AKT2 involved in several pathways and played different roles in them. We selected most pathways AKT2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF16; RASA2; CACNA2D2; CACNG6; PPP3CCA; RPS6KAL; MKNK2; TNFRSF1A; FGF13; CDC25B
ErbB signaling pathway
MAPK8A; RPS6KB1B; MAP2K4A; PIK3CG; PLCG1; CBL; CAMK2D; RAF1; PLCG2; MAP2K4B
Ras signaling pathway
GAB2; FGF14; STK4; RALBP1; CALML5; PLD1; RASSF5; RGL2; BRAP; FGF7
Rap signaling pathway
ACTG1; FGF5; FARP2; LPAR4; PRKCI; HRAS; MAP2K1; NRAS; CDC42; INS2
cGMP-PKG signaling pathway
GNAI2; IRS4; PPP3CB; GATA4; AGTR1B; PLCB1; NPR2; PDE5A; PPIF; CREB3L3
cAMP signaling pathway
RAC2; GPR119; FSHB; GRIN2C; RRAS2; GRIA1; CALM3; RYR2; RAC1; Adcy4
Chemokine signaling pathway
PLCB3; ARRB1; CCR1L1; PF4V1; Ccl27a; CCR7; CCL24; CXCL3; FGR; CCR5
HIF- signaling pathway
INS2; PGK1; MTOR; VEGFA; EGLN1; LDHA; AKT1; INS; PIK3CG; LTBR
FoxO signaling pathway
CCND2A; TGFB1; PLK1; PRKAG3B; PDPK1B; CCNB3; PIK3R3A; PRKAB1; CDKN1BA; PLK2
Sphingolipid signaling pathway
PLCB1; RAC2; TRP53; PLCB2; MAPK3; PPP2R2D; LASS1; AKT2; MAPK11; LASS5
Phospholipase D signaling pathway
RHOA; IL-8; PPAP2A; NRAS; SHC4; PIK3CA; PLCB4; KIT; CXCR2; PTK2B
mTOR signaling pathway
RPS6KAL; EIF4E1B; PDPK1B; PIK3R1; RHEB; RPS6KA2; CAB39; AKT2L; RPS6KA6; INS1
PIK-Akt signaling pathway
IFNA4; COL27A1; MDM2; GNG12; EIF4E2; IFNA8; LPAR6; LAMA1; AKT1; EIF4E1B
AMPK signaling pathway
PRKAG1; AKT3; INSR; PPP2R2A; PFKP; EIF4EBP1; CCND1; FOXO3; PIK3R2; ADIPOQ
Apoptosis
DCC; BIRC2; CFLARA; IKBKG; IKBKB; ATM; PIK3R3; CAPN2B; CRADD; NFKB1
Adrenergic signaling in cardiomyocytes
PPP2R2C; PIK3CA; PPP2R2CA; GNAI2B; GNAI1; PRKACBB; ACTC1; CREB3L3; ATP1B2; CACNG4
VEGF signaling pathway
MAP2K2A; MAPK12B; MAPK12A; RAC3A; PIK3CB; MAP2K2; PIK3CA; MAPKAPK2; PTGS2A; PLA2G4A
Osteoclast differentiation
MAPK8; FCGR2C; NCF4; GRB2; MAPK13; CSF1; LCK; SOCS3; FCGR2A; IFNAR1
Focal adhesion
PTK6; BAD; PDGFRB; VWF; MYL12.2; BIRC2; ACTN4; THBS3A; MYLPFA; MYL5
Tight junction
JAM3; MYH6; MYH15; RAB3B; CLDN7; RRAS2; PRKCH; CLDN15LA; GNAI1; CLDN20
Signaling pathways regulating pluripotency of stem cells
OTX1; AXIN2; MAPK12; ID4; INHBB; WNT7A; DLX5; HNF1A; PCGF6; LIF
Platelet activation
PIK3R5; GUCY1B3; SNAP23; PRKACA; TLN1; RAP1A; GNAI3; GP5; PIK3R2; ITGB3
Toll-like receptor signaling pathway
CXCL11; MAPK8; CCL4; IKBKG; TLR1; MYD88; IFNA12; IKBKE; TLR3; IL1B
Jak-STAT signaling pathway
AKT2; IFNA1; CCND3; PIK3CG; CNTFR; IL23R; CSF3R; IL12BA; IFNG; PIAS1
T cell receptor signaling pathway
DEF6A; PPP3CC; PAK2; SOS1; CD8A; PIK3CG; IL4; CABIN1; AKT1; NFATC2
B cell receptor signaling pathway
IKBKB; CR2; CDK2; CARD11; CRKL; PIK3AP1; DOK1B; NFKBIA; PLCG2; ACTR3
Fc epsilon RI signaling pathway
PIK3R2; IL3; MAP2K7; MAP2K3; MAPK8; MAPK13; MAPK9; LYN; PIK3CA; FCER1A
Fc gamma R-mediated phagocytosis
PLA2G4D; FCGR3A; LIMK1; PLCG2; PLA2G6; ARF6; RAC2; MARCKS; PIP5K1C; cgr2b
TNF signaling pathway
BIRC2; TNFRSF1A; MAPK13; PIK3CB; Ccl12; MAGI2; TRAF2; CCL5; MAP2K6; IL1B
Neurotrophin signaling pathway
PDPK1; TRP53; CAMK4; CDC42; CALM4; MAP2K5; ARHGDIA; TP53; RIPK2; SHC3
Cholinergic synapse
NRAS; CHRNB4; GNG13; KCNJ12; SLC5A7; GNG10; MAPK1; PIK3R2; KCNJ3; MAP2K1
Dopaminergic synapse
CALM3; ARRB2; SLC18A2; GRIA3; PRKCB; PPP2R2D; ITPR1; GNAQ; DRD2; SLC18A1
Insulin signaling pathway
PPP1CAA; FBP1B; PYGM; PYGMA; FLOT2A; PRKAR1A; PIK3R2; FLOT2B; HK3; CALM1B
Progesterone-mediated oocyte maturation
ANAPC2; MAD2L1; BRAF; MAPK10; AKT2; ANAPC11; IGF1RA; MAPK8B; PIK3R3A; PDE3B
Estrogen signaling pathway
GNAI2; CALM2; SHC3; PIK3CD; PIK3CG; HSPA1A; CALML5; GNAI3; GNAI1; HSPA6
Prolactin signaling pathway
MAPK9; LHCGR; SOCS3; INS2; ESR2; PIK3R2; SOCS6; SHC4; PPIB; SOCS4
Thyroid hormone signaling pathway
ATP2A2; PIK3CD; HDAC1; MED1; PLCD1; MED13L; PLCE1; ATP1A1; PDPK1; NOTCH2
Adipocytokine signaling pathway
TRADD; NFKBIAB; JAK2B; RXRAA; MTOR; AKT3A; MAPK8B; PPARGC1A; IKBKG; CAMKK1A
Glucagon signaling pathway
PPARA; PHKG1; PRKAA2; PFKFB1; SLC2A2; PRKAA1; ACACB; PPP3R1; PRKACB; CALML3
Regulation of lipolysis in adipocytes
INS1; TSHB; PIK3CB; GNAS; IRS1; PIK3CD; IRS2; PRKG1; GNAI1; FABP4
Insulin resistance
PPP1CAB; PRKAB1B; AKT2L; PYGB; PDPK1B; PPP1CAA; PRKCDA; INS2; PIK3R1; STAT3
Non-alcoholic fatty liver disease (NAFLD)
BID; CASP7; FASLG; NDUFA9; XBP1; UQCR11; NFKB1; NDUFA12; IL1A; UQCRH
Carbohydrate digestion and absorption
PIK3R5; PIK3R1; AMY2A; AMY1B; AMY2A2; AMY2A4; PIK3R3; ATP1B1; PLCB2; AKT2
Chagas disease (American trypanosomiasis)
PLCB4; GNA15; FAS; Il2; TLR4; TLR9; MAPK3; PPP2R2C; IRAK4; IKBKB
Toxoplasmosis
GNAO1; HSPA1A; BCL2L1; MAPK11; GNAI1; Toxoplasma Gondii Dense Granule Protein 7; IL10RB; MAP2K6; IL10RA; HSPA2
Tuberculosis
FCGR3; TNFRSF1A; IFNA6; CAMP; CASP9; HSPD1; Pla2r1; CALM3; EP300; PIK3C3
Hepatitis C
OAS1A; PDPK1; OAS2; TNFRSF1A; CD81; EIF2AK2; CLDN3; SOS1; SCARB1; BAD
Hepatitis B
NFATC3; TLR3; TBK1; ATF4; TIRAP; STAT1; IFNA4; MAP2K4; TGFBR1; PRKCG
Measles
IFNGR1; IL2RB; IFNA2; IFNA14; EIF3H; STAT1; IFNGR2; IFNA1; TNFRSF10A; CCND1
Influenza A
STAT2; TMPRSS4; PIK3CA; PABPN1; HLA-DQA1; MX1; EIF2AK4; IL8L2; IFNA14; MYD88
HTLV-I infection
WNT7B; CDC16; RAN; HLA-F; APC; PIK3R5; TGFB3; IL15RA; TBPL2; CDC26
Epstein-Barr virus infection
HSPB2; POLR3GL; CCNA2; PIK3R3; HSPA2; PSMC4; HDAC1; IL10RA; IKBKG; EIF2AK4
Pathways in cancer
FZD8; ITGA2B; MMP1A; WNT6; KITLG; WNT3; FGF2; ITGAV; MAPK3; WNT10B
Proteoglycans in cancer
WNT11; TLR2; MAP2K2; FLNC; MMP9; WNT8A; PTK2; BRAF; SDC2; RPS6KB2
Colorectal cancer
PIK3CA; MSH2; RALGDS; DCC; BIRC5; PIK3R1; MAPK3; TP53; MAPK10; PIK3R2
Renal cell carcinoma
NRAS; VHL; TCEB2; SLC2A1; FH1; FLCN; SOS1; EP300; RAC1; EPAS1
Pancreatic cancer
BRCA2; CCND1; MAPK3; STAT3; TGFB3; RAF1; RAC2; IKBKB; PIK3R2; PLD1
Endometrial cancer
ARAF; PDPK1; PIK3CG; TCF7; AXIN1; PIK3R3; GRB2; ELK1; PIK3CB; CTNNA2
Glioma
MDM2; PRKCA; PIK3CD; PTEN; PIK3CA; CAMK2B; PRKCG; NRAS; PDGFA; AKT2
Prostate cancer
ARAF; INS2; MAPK3; PDGFB; INS; GRB2; CREB3L1; RELA; NKX3-1; KRAS
Melanoma
FGF1; KRAS; CDH1; Pdgfa&Pdgfb; RAF1; PIK3CD; FGF14; PDGFB; FGF12; FGF3
Chronic myeloid leukemia
CTBP1; CBL; TGFB3; MAP2K2; ARAF; PIK3R2; STAT5B; TRP53; MDM2; PIK3CG
Acute myeloid leukemia
MAPK1; PIM2; KRAS; PIK3CG; HRAS; RUNX1T1; SOS1; PIK3R1; MYC; RPS6KB1
Small cell lung cancer
PTEN; LAMB4; PIK3CG; TRP53; LAMC2; LAMA2; ITGA6; RARB; BIRC3; LAMB3
Non-small cell lung cancer
RASSF5; MAP2K2; PRKCB; EML4; PRKCA; TRP53; MAPK3; BAD; RXRG; PLCG2
Central carbon metabolism in cancer
PFKM; AKT2; MAPK1; PIK3CB; MAP2K2; FGFR3; SLC1A5; NTRK1; PKM2; PDHB
Choline metabolism in cancer
SLC22A1; PLD1; PCYT1A; PIP5K1B; WASF3; PPAP2B; PRKCB; TSC1; PLA2G4B; PIK3R1

Protein Function

AKT2 has several biochemical functions, for example, ATP binding, protein binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT2 itself. We selected most functions AKT2 had, and list some proteins which have the same functions with AKT2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACTC1; HNRNPU; NEK9; CHST13; LANCL2; DSTYK; ATP8A1; ULK1; DHX37; WNK2
Function protein binding
Related Protein PTGDS; BST2; KAT2B; STAG1; PLCG1; PRMT8; PRKAB1; KAT8; RIBC1; SCRN1
Function protein kinase C binding
Related Protein AVPR1A; FLNA; IRS1; TDG; PKN1; PEA15A; PAWR; SDPRB; DSP; PICK1
Function protein serine/threonine kinase activity
Related Protein ROCK2B; PKN1; ZAK; SLK; GRK7B; PDPK1; STK4; ACVRL1; BMPR1BA; MAPK11

Interacting Protein

AKT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT2.
HSP90AB1; crosstide; CASP3; GSK3B; LRRK2; SH3RF1; MYH13; VIM; SETDB1; CDC37; SORBS2; APOA1; APOB

AKT2 Related Articles

van de Luijtgaarden, ACM; Roeffen, MHS; et al. IGF signaling pathway analysis of osteosarcomas reveals the prognostic value of pAKT localization. FUTURE ONCOLOGY 9:1733-1740(2013).
Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

AKT2 Related Gene Family

TGF