aldh2
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  • Official Full Name
  • aldehyde dehydrogenase 2 family (mitochondrial)
  • Background
  • This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while ~50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
  • Synonyms
  • ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase, mitochondrial; ALDH class 2; liver mitochondrial ALDH; acetaldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2; ALDM; ALDHI; ALDH-E2; MGC1806
Cat.#:ALDH2-27037THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2
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Cat.#:ALDH2-27039THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2, His-tagged
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Cat.#:ALDH2-130HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ALDH2 protein, MYC/DDK-tagged
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Cat.#:ALDH2-131HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH2 protein, GST-tagged
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Cat.#:ALDH2-139HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2 protein
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Cat.#:ALDH2-2122HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDH2 protein, His & S-tagged
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Cat.#:ALDH2-444HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDH2 Protein, GST-tagged
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Cat.#:ALDH2-1525MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALDH2 Protein
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Cat.#:Aldh2-83MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Aldh2, His-tagged
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Cat.#:Aldh2-3264RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Aldh2, His-tagged
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Cat.#:ALDH2-620RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALDH2 Protein
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Cat.#:ALDH2-8918HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALDH2 293 Cell Lysate
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Cat.#:Kit-0076Tag:N/A
Source (Host):Species:
Product nameMitochondrial Aldehyde Dehydrogenase (ALDH2) Activity Assay Kit
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Involved Pathway

ALDH2 involved in several pathways and played different roles in them. We selected most pathways ALDH2 participated on our site, such as Glycolysis / Gluconeogenesis, Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
PGM2; FBP1; PGAM1B; HK3; ALDOCA; PGM1; GPI1; pykF; ENO1A; FBP2
Pentose and glucuronate interconversions
GKUP; UGT1A6; OXSR1; ALDH2.1; DHDH; ALDH1B1; UGT1A4; CRYL1; DCXR; GUSB
Ascorbate and aldarate metabolism
MIOX; UGT1A3; ALDH3A2; ALDH9A1; UGT2A1; RGN; ALDH3A2A; UGT1A6A; ALDH2.1; UGDH
Fatty acid degradation
ALDH9A1A.1; ACAA1; ADH6; ACSL5; ACSL3A; CYP4A11; ACSL4B; ACADL; ALDH3A2; ACSL1B
Valine, leucine and isoleucine degradation
HSD17B10; OXCT2B; ACAA1A; OXCT1A; MCEE; ACAA2; ACAT2; HADH; MCCC2; AOX1
Lysine degradation
ALDH1B1; ALDH3A2; BBOX1; GCDHA; SUV420H2; HADHAA; PLOD1; SETD8; SETD2; MLL5
Arginine and proline metabolism
OAT; HOGA1; GAMT; CKM; GOT1; GOT2A; Ckmm; MAOA; ALDH9A1B; CKMT1B
Histidine metabolism
MAOB; ALDH3A1; ASPA; CARNS1; ALDH1B1; MAOA; ALDH2.1; ALDH3A2A; ALDH9A1B; ALDH2.2
Tryptophan metabolism
ALDH2; ALDH9A1B; RNF25; AOX3; AOX2P; HADH; ALDH2.2; CYP4F12; GCDHA; AOX3L1
beta-Alanine metabolism
ALDH3A1; ALDH6A1; ALDH3A2A; ALDH1A3; HADHA; ALDH3B2; MLYCD; ALDH7A1; ALDH2.1; ALDH3B1
Glycerolipid metabolism
DGAT1; AKR1A1; MOGAT1; GLA; LPIN3; GPAM; MBOAT2B; ALDH2; CEL.1; PNLIPRP1
Pyruvate metabolism
PDHA1; PC; FH; MDH1; PDK3; MDH2; ALDH3A2; PKMA; LDHAL6B; LDHBA
Metabolic pathways
glpK; GOT1; HADHAB; UPP1; INPP1; TKTL1; UQCRC2A; PCYT1AB; UAP1; FBP2

Protein Function

ALDH2 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH2 itself. We selected most functions ALDH2 had, and list some proteins which have the same functions with ALDH2. You can find most of the proteins on our site.
Function
Related Protein
Function aldehyde dehydrogenase (NAD) activity
Related Protein ALDH3A2; ALDH1B1; ALDH1L2; ALDH1L1; ALDH8A1; ALDH1A1; ALDH6A1; ALDH2; ALDH9A1B; ALDH3A2B
Function aldehyde dehydrogenase [NAD(P)+] activity
Related Protein ALDH3A2A; ALDH3A2; ALDH1A3; ALDH3B1; ALDH3A1; ALDH2; ALDH3B2; ALDH3A2B
Function electron carrier activity
Related Protein CYP1A2; GLRX5; GRXCR1; CYCSB; AKR7A2; ACOX1; CYBA; FDX1B; COX7A3; GCDH

Interacting Protein

ALDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH2.
ALDH1A1; FHIT; UBA5; SIRT3; RPL13A; ITGB3BP; UNC119; CRMP1; q7cgs8_yerpe; SLC35F6; FAM45A; IGSF21; C14orf1; 15-deoxy-delta(12,14; ICT1; GABARAPL1; SIRT4

ALDH2 Related Articles

Lai, CL; Yao, CT; et al. Dominance of the Inactive Asian Variant Over Activity and Protein Contents of Mitochondrial Aldehyde Dehydrogenase 2 in Human Liver. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:44-50(2014).
Yokoyama, A; Mizukami, T; et al. Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 and Liver Cirrhosis, Chronic Calcific Pancreatitis, Diabetes Mellitus, and Hypertension Among Japanese Alcoholic Men. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37:1391-1401(2013).