aldoa
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  • Official Full Name
  • aldolase A, fructose-bisphosphate
  • Background
  • The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
  • Synonyms
  • ALDOA; aldolase A, fructose-bisphosphate; fructose-bisphosphate aldolase A; ALDA; Aldolase A fructose bisphosphatase; OTTHUMP00000162983; OTTHUMP00000162984; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase; GSD12
Cat.#:ALDOA-26500THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDOA, His-tagged
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Cat.#:ALDOA-1933HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Aldolase A, Fructose-bisphosphate, His-tagged
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Cat.#:ALDOA-384HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDOA Protein, His-tagged
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Cat.#:ALDOA-455HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALDOA Protein, GST-tagged
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Cat.#:ALDOA-651HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDOA protein, His & T7-tagged
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Cat.#:ALDOA-9566HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALDOA, His-tagged
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Cat.#:ALDOA-625RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALDOA Protein
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Cat.#:ALDOA-8912HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALDOA 293 Cell Lysate
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Cat.#:ALDOA-8913HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ALDOA 293 Cell Lysate
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Involved Pathway

ALDOA involved in several pathways and played different roles in them. We selected most pathways ALDOA participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
AKR1A1B; ALDOB; GPI; ENO1; PGK2; ALDH3B2; HK1; ENO1A; HK2; HK3
Pentose phosphate pathway
PRPS1B; ALDOAA; deoC; PGD; GPI1; FBP1B; PFKMA; FBP1A; GPI; PGLS
Fructose and mannose metabolism
FBP1B; TSTA3; TIGARA; GMPPAA; FBP1A; TIGARB; AKR1B1L; HK3; PFKM; GMPPAB
Metabolic pathways
ACSL3A; CHSY1; POLR2A; B4GALT4; DNMT3AA; NME5; PGLS; GMPPAB; AOC1; CERS1
Carbon metabolism
ENO3; pykF; HK1; GPT2; OGDHL; FBP2; ACSS1; PGD; SDHD; H6PD
Biosynthesis of amino acids
ALDOCB; GPT; PYCRL; GLULC; MAT1A; GOT2; PGK2; TKTL2; GOT1; PHGDH
HIF- signaling pathway
PIK3CA; RPS6KB1; MAP2K2; MTOR; ALDOA; PFKFB3; IL6; FLT1; ERBB2; PRKCA

Protein Function

ALDOA has several biochemical functions, for example, actin binding, cytoskeletal protein binding, fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDOA itself. We selected most functions ALDOA had, and list some proteins which have the same functions with ALDOA. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein FBXO25; VASPA; MYO5B; DAAM1; WASF3B; CCDC88A; NF2; SMYHC1; TWF1A; CNN3
Function cytoskeletal protein binding
Related Protein PTPN4B; NF2A; PACSIN3; PACSIN2; TOR1AIP1; ABI1; LDB3; FLNC; ANXA2A; DES
Function fructose binding
Related Protein ALDOA; PFKM; PFKL; ALDOB
Function fructose-bisphosphate aldolase activity
Related Protein ALDOAB; ALDOCB; ALDOA; ALDOC; ALDOAA; ALDOB; ALDOCA
Function identical protein binding
Related Protein SOD1; FBLN1; TARDBP; SETX; DNMT3A; SLC22A1; L1CAM; CLDN6; KHDRBS1; GOT1L1
Function poly(A) RNA binding
Related Protein PPP1R2P9; TRMT6; LTA4H; HSPD1; EXOSC9; MRPS30; TFB2M; DEK; C14orf21; WDR36
Function protein binding
Related Protein PIK3C3; NOTCH3; PPFIA4; MASP1; ADNP; NEK2; NFS1; SLC30A2; FMO4; CT45A3
Function tubulin binding
Related Protein STMN4L; PARK2; RITA1; STMN2B; TTLL4; BRCA1; AGBL4; STMN1A; MAP1S; CDK5RAP2

Interacting Protein

ALDOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDOA here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDOA.
PCNA; VCAM1; YWHAZ; OSBPL10; USP15; CACNA1A; BCAT2; EGFR; ALDOB; TFAP2A; ENO1; ENO3; MLH1