Recombinant Human ALDOA Protein, His-tagged

• Cat.No.: ALDOA-384H
• Product Overview: Recombinant Human ALDOA(Met1-Tyr364), transcript variant 1, fused with His tag at C-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
• Source: E. coli
• Tag: His
• Form: 20mM Tris-HCl, 100mM NaCl, 20% Glycerol, pH 8.0. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 40.5 kDa
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ALDOA aldolase A, fructose-bisphosphate [ Homo sapiens ]
• Official Symbol: ALDOA
• Synonyms: ALDOA; aldolase A, fructose-bisphosphate; fructose-bisphosphate aldolase A; muscle-type aldolase; lung cancer antigen NY-LU-1; fructose-1,6-bisphosphate triosephosphate-lyase; ALDA; GSD12
• Gene ID: 226
• mRNA Refseq: NM_000034
• Protein Refseq: NP_000025
• MIM: 103850
• UniProt ID: P04075