ALOX5AP
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Official Full Name
arachidonate 5-lipoxygenase-activating protein
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Overview
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011] -
Synonyms
ALOX5AP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Equus caballus (Horse)
- Homo sapiens (Human)
- Human
- Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
- Macaca mulatta (Rhesus macaque)
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Ovis aries (Sheep)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Zebrafish
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- In vitro E. coli expression system
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- SUMO
- MYC
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ALOX5AP Related Research Area
ALOX5AP involved in several pathways and played different roles in them. We selected most pathways ALOX5AP participated on our site, such as Arachidonic acid metabolism, Eicosanoid Synthesis, IL-5 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5AP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | PTGDSA;FAM213B;PTGDSB;CYP4A14;AWAT1;PTGS2B;GPX5;EPHX2;CYP2C37 |
| Eicosanoid Synthesis | ALOX5AP;PNPLA8;DPEP1 |
| IL-5 Signaling Pathway | GSK3AB;UNC119;SDCBP;ALOX5AP |
| Metabolism | MED7;BCHE;UPP2;ARSI;UGT1B4;SLC25A20;DSEL;ALOX5B.3;AMD2 |
| Metabolism of lipids and lipoproteins | APOA5;ACOT7;ACSF3;LMF1;ACOT11B;DPEP2;MTP;SCP2B;GLTPD1 |
| Selenium Pathway | PRDX2;SAA2-SAA4;SERPINA3;CRP;MSRB1;SAA4;SELT;PRDX4;TXNRD2 |
| Synthesis of 5-eicosatetraenoic acids | ALOX5B.2;ALOX5AP;ALOX5B.3 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | PTGR1;DPEP1;DPEP2;ALOX5AP;ALOX5B.2;ALOX5B.3 |
ALOX5AP has several biochemical functions, for example, arachidonic acid binding, enzyme activator activity, NOT glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5AP itself. We selected most functions ALOX5AP had, and list some proteins which have the same functions with ALOX5AP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arachidonic acid binding | S100A8;STX3;CYP4A14;PPARG;S100A9;CYP4F14;ALOX5AP |
| enzyme activator activity | TRIM23;ARL1;MMP15;CLPS;PRKCD;CLPSL1;PSAPL1;CTSA;DCP1A |
| NOT glutathione peroxidase activity | |
| NOT glutathione transferase activity | ALOX5AP;CLIC1;CLIC2;CLIC3;CLIC5 |
| NOT leukotriene-C4 synthase activity | |
| protein N-terminus binding | NPAT;NTSR1;MORF4L1;TRAF6;THAP7;HAX1;DCN;DCTN4;RPS21 |
| protein binding | CSNK2B;TSGA10;IL5;NTRK3;METTL13;UBE2E1;EDA;DDIT3;RAB5B |
ALOX5AP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5AP here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5AP.
CLIC1
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