ALOX5AP Protein, arachidonate 5-lipoxygenase-activating protein


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Official Full Name arachidonate 5-lipoxygenase-activating protein
Background This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Synonyms ALOX5AP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.Coli or Yeast
    • HEK293T
    • in vitro E. coli
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALOX5AP-2725H Recombinant Human ALOX5AP Protein (1-161 aa), His-SUMO-tagged in vitro E. coli His/SUMO
    Mouse Alox5ap-585M Recombinant Mouse Alox5ap Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ALOX5AP-27299TH Recombinant Human ALOX5AP Wheat Germ N/A
    Human ALOX5AP-3336H Recombinant Human ALOX5AP, His tagged Insect Cell His
    Human ALOX5AP-488H Recombinant Human ALOX5AP Protein, GST-tagged Wheat Germ GST
    Human ALOX5AP-667HCL Recombinant Human ALOX5AP cell lysate Insect Cell N/A
    Mouse ALOX5AP-1568M Recombinant Mouse ALOX5AP Protein Mammalian Cell His
    Mouse Alox5ap-3611M Recombinant Mouse Alox5ap, His-tagged E.Coli or Yeast His
    Rat ALOX5AP-639R Recombinant Rat ALOX5AP Protein Mammalian Cell His
    Rhesus Macaque ALOX5AP-309R Recombinant Rhesus monkey ALOX5AP Protein, His-tagged Mammalian Cell His
    Chicken ALOX5AP-5393C Recombinant Chicken ALOX5AP Mammalian Cell His
    Zebrafish ALOX5AP-10415Z Recombinant Zebrafish ALOX5AP Mammalian Cell His

    ALOX5AP involved in several pathways and played different roles in them. We selected most pathways ALOX5AP participated on our site, such as Arachidonic acid metabolism, Eicosanoid Synthesis, IL-5 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5AP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism FAAH2; PLA2G4C; ALOX5B.3; CBR1; GPX7; GPX1; CYP2J5; ALOX5A; GPX5; CYP4B1
    Eicosanoid Synthesis ALOX5AP; DPEP1; PNPLA8
    IL-5 Signaling Pathway UNC119; SDCBP; GSK3AB; ALOX5AP
    Metabolism CYP8B2; COX14; B3GNT2A; FAAH2; SREBF2; ADA; SLC19A2; CHKA; PLCD3; NFYBA
    Metabolism of lipids and lipoproteins OSBP; ANKRD1; TMEM195; PLD6; LMF2; GPAT2; PTGDSA; CYP4B1; MED6; ALOX5AP
    Synthesis of 5-eicosatetraenoic acids ALOX5AP; ALOX5B.3; ALOX5B.2
    Synthesis of Leukotrienes (LT) and Eoxins (EX) DPEP2; ALOX5AP; PTGR1; DPEP1; ALOX5B.2; ALOX5B.3

    ALOX5AP has several biochemical functions, for example, arachidonic acid binding, enzyme activator activity, NOT glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5AP itself. We selected most functions ALOX5AP had, and list some proteins which have the same functions with ALOX5AP. You can find most of the proteins on our site.

    Function Related Protein
    arachidonic acid binding PPARG; CYP4A14; STX3; ALOX5AP; S100A9; S100A8; CYP4F14
    enzyme activator activity ARL1; ALDH1A2; GMFB; DAOA; DNMT3L; RAB3GAP2; ALOX5AP; SAE1; GM1679; UBA2
    NOT glutathione peroxidase activity ALOX5AP
    NOT glutathione transferase activity CLIC5; CLIC1; ALOX5AP; CLIC3; CLIC2
    NOT leukotriene-C4 synthase activity ALOX5AP
    protein N-terminus binding KCNIP2; TSC1; EIF5A; STX5; SLA2; ERCC4; NCOA3; ALG2; MEN1; HAX1
    protein binding EPHB6; TCTE3; CA2; SHPRH; ESD; RUNX1T1; ASIC2; PTPRC; CNIH2; ISOC1

    ALOX5AP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5AP here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5AP.


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