alox5ap
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  • Official Full Name
  • arachidonate 5-lipoxygenase-activating protein
  • Background
  • This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
  • Synonyms
  • ALOX5AP; arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein;
Cat.#:ALOX5AP-2725HTag:His-SUMO
Source (Host):E. coli Cell FreeSpecies:Human
Product nameRecombinant Human ALOX5AP Protein (1-161 aa), His-SUMO-tagged
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Cat.#:ALOX5AP-3336HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALOX5AP, His tagged
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Cat.#:ALOX5AP-488HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALOX5AP Protein, GST-tagged
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Cat.#:ALOX5AP-1568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALOX5AP Protein
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Cat.#:Alox5ap-3611MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Alox5ap, His-tagged
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Cat.#:ALOX5AP-639RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALOX5AP Protein
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Cat.#:ALOX5AP-309RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ALOX5AP Protein, His-tagged
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Cat.#:ALOX5AP-5393CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALOX5AP
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Cat.#:ALOX5AP-10415ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALOX5AP
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Cat.#:ALOX5AP-667HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ALOX5AP cell lysate
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Involved Pathway

ALOX5AP involved in several pathways and played different roles in them. We selected most pathways ALOX5AP participated on our site, such as Arachidonic acid metabolism, Eicosanoid Synthesis, IL-5 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5AP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
ALOX5B.2; GPX2; GPX6; CYP2V1; PLA2G4D; PTGS2B; PTGDSA; EPHX2; ALOX5; PLA2G2F
Eicosanoid Synthesis
DPEP1; PNPLA8; ALOX5AP
IL-5 Signaling Pathway
SDCBP; GSK3AB; ALOX5AP; UNC119
Metabolism
AQP1A.2; CLPS; CYP2K18; YY2; DPYDA.1; UCP2; FABP12; ACY3; EPM2A; CYP2AD3
Metabolism of lipids and lipoproteins
MED22; ACOT6; CYP4T8; MED25; MED19; LMF1; MED21; APOC2; SUMF2; GLTPD1
Selenium Pathway
SELK; ALOX5AP; DIO2; MSRB1; SAA2-SAA4; SAA2; CRP; PRDX4; PRDX2; TXNRD3IT1
Synthesis of 5-eicosatetraenoic acids
ALOX5AP; ALOX5B.3; ALOX5B.2
Synthesis of Leukotrienes (LT) and Eoxins (EX)
ALOX5AP; PTGR1; DPEP1; DPEP2; ALOX5B.3; ALOX5B.2

Protein Function

ALOX5AP has several biochemical functions, for example, arachidonic acid binding, enzyme activator activity, NOT glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5AP itself. We selected most functions ALOX5AP had, and list some proteins which have the same functions with ALOX5AP. You can find most of the proteins on our site.
Function
Related Protein
Function arachidonic acid binding
Related Protein PPARG; STX3; CYP4F14; CYP4A14; S100A9; ALOX5AP; S100A8
Function enzyme activator activity
Related Protein PPP1R12B; MMP15; MMP17; APOA5; RAB3GAP2; MMP24; TRIM23; SFTPBB; LTC4S; MMP16
Function NOT glutathione peroxidase activity
Related Protein ALOX5AP
Function NOT glutathione transferase activity
Related Protein CLIC2; CLIC1; ALOX5AP; CLIC3; CLIC5
Function NOT leukotriene-C4 synthase activity
Related Protein ALOX5AP
Function protein N-terminus binding
Related Protein TRAF6; SLA2; ERCC6; RASSF1; ACOX1; NCOR2; NCOA1; MNAT1; TDRD7; HESX1
Function protein binding
Related Protein MYOC; SCEL; H2AFY; SNRPB; CEBPG; TLE2; IMMT; ACTR1B; CECR2; AGRN

Interacting Protein

ALOX5AP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5AP here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5AP.
CLIC1