|Official Full Name||Ankyrin 3, Node Of Ranvier (ankyrin G)|
|Background||Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||ANK3; ANKYRIN-G; ankyrin-3; ankyrin G119; ankyrin 3, node of Ranvier (ankyrin G); ankyrin-3, node of Ranvier; FLJ45464; OTTHUMP00000019653; OTTHUMP00000019656; OT-THUMP00000217458; OTTHUMP00000217575|
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ANK3 involved in several pathways and played different roles in them. We selected most pathways ANK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
ANK3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANK3 itself. We selected most functions ANK3 had, and list some proteins which have the same functions with ANK3. You can find most of the proteins on our site.
ANK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANK3.