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Recombinant Rat ANK3 Protein

Cat.No. : ANK3-671R
Product Overview : Recombinant Rat ANK3 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Rat
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Ank3 ankyrin 3, node of Ranvier [ Rattus norvegicus ]
Official Symbol : ANK3
Gene ID : 361833
mRNA Refseq : NM_001033984.1
Protein Refseq : NP_001029156.1
MIM :
UniProt ID : O70511

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (19)

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Can ANK3 be used as a diagnostic marker for certain diseases? 04/14/2023

ANK3 mutations have been identified as potential diagnostic markers for specific diseases, such as certain forms of autism spectrum disorder and bipolar disorder. Genetic testing to detect these mutations can aid in the diagnosis and classification of these disorders, facilitating personalized treatment and management approaches.

Which tissues or organs express the ANK3 protein? 06/29/2022

The ANK3 protein is expressed in various tissues and organs throughout the body, with particularly high levels in the brain and heart. In the brain, ANK3 is found in neurons, particularly in axons and dendrites, where it is essential for neuronal development, synaptic transmission, and the formation of functional neural networks. In the heart, ANK3 is present in cardiac myocytes and plays a critical role in the organization of the cardiac conduction system.

Is there any relationship between ANK3 and neurodegenerative diseases? 11/07/2021

While ANK3 mutations have primarily been linked with neurodevelopmental and psychiatric disorders, recent studies suggest potential involvement of ANK3 in neurodegenerative diseases. ANK3 has been found to interact with proteins associated with neurodegeneration, such as tau and alpha-synuclein. However, more research is needed to understand the role of ANK3 in neurodegenerative processes and its contribution to diseases like Alzheimer's and Parkinson's.

Does ANK3 have any isoforms or splice variants? 11/02/2021

Yes, ANK3 has multiple isoforms and splice variants that are generated through alternative splicing of its gene. These variants exhibit tissue-specific expression patterns and may have distinct functions. For example, the longest isoform, known as ankyrin-G270, is predominantly expressed in the brain, while shorter isoforms, such as ankyrin-G480, are found in both the brain and heart.

What are the potential implications of ANK3 dysregulation in psychiatric disorders? 11/27/2020

ANK3 dysregulation has been implicated in several psychiatric disorders, including bipolar disorder, schizophrenia, and major depressive disorder. Understanding the specific mechanisms underlying ANK3-related pathogenesis can provide insights into the molecular and cellular processes contributing to these disorders. It may ultimately lead to the development of targeted therapies that can restore ANK3 function and improve clinical outcomes for individuals with psychiatric conditions.

How does ANK3 interact with other proteins in the cell? 07/26/2020

ANK3 interacts with a variety of proteins in the cell, particularly at the synapse. It binds to ion channels, receptors, scaffolding proteins, and cytoskeletal components, among others. These interactions are crucial for the proper localization and stabilization of proteins, ensuring their function and integrity within specific cellular compartments. The exact protein-protein interactions involving ANK3 may vary depending on the cell type and subcellular localization, highlighting the diverse roles and functions of ANK3 in different cellular contexts.

How does ANK3 contribute to neuronal excitability? 02/03/2020

ANK3 plays a role in regulating neuronal excitability by influencing the localization and function of ion channels, particularly voltage-gated sodium channels (NaV). ANK3 helps anchor NaV channels at the axon initial segment, a specialized region of the neuron involved in action potential initiation. Proper clustering of NaV channels by ANK3 is crucial for maintaining the appropriate excitability and transmission of electrical signals along the neuronal network. Dysregulation of ANK3 can disrupt this process, leading to altered neuronal excitability and potential neurological disorders.

Can ANK3 mutations be inherited? 12/05/2019

Yes, ANK3 mutations can be inherited and passed down in families, making them heritable. In some cases, these mutations can contribute to a higher risk of developing certain psychiatric disorders, such as bipolar disorder. However, the inheritance pattern of ANK3 mutations may vary, and not all individuals carrying a mutation will necessarily exhibit the associated phenotype. Studies have shown that the interaction between ANK3 mutations and environmental factors also plays a role in determining the development and manifestation of psychiatric disorders.

Is there ongoing research on targeting ANK3 for therapeutic purposes? 11/09/2019

While the targeting of ANK3 for therapeutic purposes is an area of active research, there are currently no known targeted therapies specifically designed to modulate ANK3 function. However, understanding the role of ANK3 in various diseases and disorders may lead to the development of future therapeutic strategies aimed at restoring proper protein organization and function within cells.

Are there any animal models available to study ANK3 function? 05/25/2019

Yes, several animal models have been used to study ANK3 function. Mouse models with targeted deletions or mutations in the Ank3 gene have been generated, allowing researchers to study the effects of ANK3 loss or dysfunction in vivo. These models have provided valuable insights into the role of ANK3 in neuronal development, synaptic function, and psychiatric disorders. Additionally, other animal models, such as zebrafish and fruit flies, have been used to study ANK3 function in a developmental context.

Are there any known regulators of ANK3 expression or activity? 03/07/2019

Several transcription factors and signaling pathways have been identified as regulators of ANK3 expression and activity. For example, the Wnt/beta-catenin signaling pathway has been shown to modulate ANK3 expression in the brain. In addition, methyl-CpG-binding protein 2 (MECP2), a key regulator of neuronal gene expression, has been found to interact with ANK3 and modulate its function. Further research is needed to uncover additional regulators and their mechanisms of action.

What are the consequences of ANK3 mutations? 02/12/2019

ANK3 mutations have been associated with various diseases and disorders, including neurodevelopmental disorders such as autism spectrum disorder and intellectual disability, as well as psychiatric disorders such as bipolar disorder and schizophrenia. These mutations can disrupt ANK3's role in membrane organization and protein targeting, leading to altered electrical signaling, synaptic dysfunction, and impaired neuronal connectivity.

Are there any animal models available to study ANK3-related disorders? 08/25/2018

Animal models, particularly mice, have been developed to study ANK3-related disorders. These models often involve the introduction of ANK3 mutations or the deletion of specific ANK3 isoforms to mimic the genetic alterations found in patients. By studying these models, researchers can gain insights into the molecular mechanisms underlying ANK3-related disorders and identify potential therapeutic strategies.

Can ANK3 be used as a therapeutic target for psychiatric disorders? 07/06/2018

ANK3 shows promise as a potential therapeutic target for psychiatric disorders, particularly bipolar disorder and schizophrenia. By modulating ANK3 expression or its protein interactions, it may be possible to normalize neuronal signaling, synaptic function, and restore proper synaptic connectivity. However, further understanding of ANK3's precise role in these disorders and developing specific interventions is needed before targeting ANK3 therapeutically becomes a reality.

Are there any known drugs or compounds that can modulate ANK3 activity? 01/12/2018

There are currently no specific drugs or compounds that directly modulate ANK3 activity. However, certain medications used in the treatment of psychiatric disorders, such as lithium for bipolar disorder, have been shown to indirectly affect ANK3 expression and function. Additionally, ongoing research aims to identify small molecules or compounds that can target ANK3 and normalize its protein-protein interactions and cellular function.

How is ANK3 involved in the development and maintenance of neuronal connections? 03/11/2017

ANK3 plays a crucial role in the development and maintenance of neuronal connections, known as synapses. It interacts with various synaptic proteins, such as ion channels and receptors, and ensures their proper localization and stability at the synapse. Disruptions in ANK3 function can lead to abnormal synapse formation, connectivity deficits, and impaired neuronal communication, which can contribute to neurodevelopmental disorders and psychiatric conditions.

What are the known binding partners of ANK3? 12/21/2016

ANK3 interacts with a wide range of proteins involved in membrane organization, ion channel regulation, and synaptic signaling. Some of the known binding partners of ANK3 include voltage-gated sodium channels (Nav1.1, Nav1.2, Nav1.6), ionotropic glutamate receptors (GluN2B subunit of NMDA receptor), and the inositol triphosphate receptor. These interactions are critical for the proper targeting and function of these proteins.

Can ANK3 mutations lead to cardiac disorders? 10/18/2016

Yes, ANK3 mutations have been associated with cardiac disorders, specifically arrhythmias and long QT syndrome (LQTS). ANK3 is critical for the organization of cardiac ion channels and the proper functioning of the cardiac conduction system. Mutations in ANK3 can lead to abnormal ion channel clustering, disrupted electrical signaling, and increased susceptibility to arrhythmias and LQTS, which can be life-threatening.

How is ANK3 linked to the regulation of ion channels and channelopathies? 01/18/2016

ANK3 plays a crucial role in the organization and localization of ion channels within cells, particularly in neurons and cardiomyocytes. It ensures proper clustering of ion channels at specific cellular compartments, such as the axon initial segment or the cardiac intercalated discs. ANK3 mutations can disrupt these interactions, leading to mislocalization or altered activity of ion channels, which can contribute to channelopathies, such as epilepsy or cardiac arrhythmias. Understanding ANK3's role in ion channel regulation is instrumental in unraveling the mechanisms underlying these disorders.

Customer Reviews (4)

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Reviews
01/19/2023

    ANK3 protein demonstrates outstanding performance in ELISA assays, making it highly recommended for researchers and scientists.

    04/24/2021

      Its stability and well-defined structure make it an excellent candidate for visualizing and understanding the three-dimensional arrangement of proteins at a high resolution.

      04/11/2017

        Its superior binding affinity and specificity enable accurate and reliable detection of target analytes in various biological samples.

        10/06/2016

          ANK3 protein has proven to be instrumental in protein electron microscopy structure analysis.

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