arhgap35
Share
  • Official Full Name
  • Rho GTPase activating protein 35
  • Background
  • The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids.
  • Synonyms
  • glucocorticoid receptor DNA binding factor 1; Rho GAP p190A; ARHGAP35; Rho GTPase-activating protein 35; GRF-1; MGC10745; KIAA1722; P190-A; P190A; glucocorticoid receptor DNA-binding factor 1; p190ARhoGAP; GRF1; p190RhoGAP; Glucocorticoid receptor repression factor 1; GRLF1; Rho GTPase activating protein 35
Cat.#:ARHGAP35-5363HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARHGAP35 Protein, GST-tagged
+Inquiry
Cat.#:ARHGAP35-26370THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARHGAP35, His-tagged
+Inquiry

Involved Pathway

ARHGAP35 involved in several pathways and played different roles in them. We selected most pathways ARHGAP35 participated on our site, such as Focal adhesion, Platelet activation, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP35 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal adhesion
LAMA4; VEGFC; ITGA3; SHC4; PDPK1B; TNK2; ITGA1; MYLK; RAF1B; KDR
Platelet activation
PRKG1; GNAS; PIK3R3; P2RY1; ACTG1; Adcy4; MAPK3; PPP1CC; RHOA; PLA2G4C
Leukocyte transendothelial migration
Itgam&Itgb2; JAM3; RHOA; MYL9; CLDN4; CDH5; ACTG1; MYL5; RHOH; JAM2
Regulation of actin cytoskeleton
ARPC4L; MYLK4; FN1; PXNA; LIMK1; VIL1; FGF8; Itga10&Itgb1; ITGA2; PDGFRB

Protein Function

ARHGAP35 has several biochemical functions, for example, DNA binding, GTP binding, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP35 itself. We selected most functions ARHGAP35 had, and list some proteins which have the same functions with ARHGAP35. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF554; NR6A1; RECQL; ZNF563; ZNF823; PQBP1; ZFP827; Ar; ZNF557; GATA4
Function GTP binding
Related Protein MFN1; GBP4; RAC1B; FPGT; EHD2B; RHOGC; RASL11A; GUCY1A3; RAB2A; TUBA8L3
Function GTPase activator activity
Related Protein TBC1D15; STARD13; SRGAP2B; ARHGAP17; GIT2B; RASGRP3; DAB2IPB; TBC1D3C; SGSM3; RGS19
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein SATB1; EAF2; LYL1; E2F7; ETV6; GATA5; CGGBP1; ASCL3; CSDA; HOXD9
Function transcription corepressor activity
Related Protein ZNF274; TAF9B; ZBTB32; NANOG; DNMT3B; SAP18; RCOR2; ATF5; CREG1; HEYL
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ETV7; HMX1; NFKB1; MITF; DMBX1; ETV3; MSX2; ARHGAP35; JARID2; BCL6A

Interacting Protein

ARHGAP35 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP35 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP35.
pi3p; BCL6

ARHGAP35 Related Articles

Bosch, DE; Siderovski, DP; et al. Entamoeba histolytica RacC Selectively Engages p21-Activated Kinase Effectors. BIOCHEMISTRY 54:404-412(2015).
Zhao, JM; Xu, H; et al. Rho GTPase-Activating Protein 35 rs1052667 Polymorphism and Osteosarcoma Risk and Prognosis. BIOMED RESEARCH INTERNATIONAL :-(2014).