ART1
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Official Full Name
ADP-ribosyltransferase 1
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Overview
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. -
Synonyms
ART1; ADP-ribosyltransferase 1; GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; ART2; CD296; ADP ribosyltransferase 1; ADP ribosyltransferase 2; ART 1; CD296 antigen; GPI linked NAD(P)(+) arginine ADP ribosyltransferase 1; MGC133217; Mono(ADP ribosyl)transferase; RT6; ADP-ribosyltransferase 2; mono(ADP-ribosyl)transferase 1;
- Cell & Tissue Lysates
- Recombinant Proteins
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- E.coli
- HEK293
- Human Cells
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- DYKDDDDK
- GST
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ART1-8672HCL | Recombinant Human ART1 293 Cell Lysate | HEK293 | N/A |
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| Human | ART1-2823H | Recombinant Human ART1 Protein, His-tagged | E.coli | His |
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| Human | ART1-151H | Recombinant Human ART1 Protein, DYKDDDDK-tagged | Human Cells | DYKDDDDK |
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| Human | ART1-100H | Recombinant Human ART1 Protein, His-tagged | E.coli | His |
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| Human | ART1-1335H | Recombinant Human ART1 Protein (23-295 aa), His-tagged | Yeast | His | 23-295 aa |
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| Human | ART1-4516H | Recombinant Human ART1 Protein (Met1-Ser295), C-His tagged | Mammalian cells | C-His | Met1-Ser295 |
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| Human | ART1-2553H | Recombinant Human ART1 protein, GST-tagged | E.coli | GST | 23-295aa |
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| Human | ART1-3301H | Recombinant Human ART1 protein(Met1-Asn294), His-tagged | HEK293 | C-His | Met1-Asn294 |
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| Mouse | Art1-248M | Recombinant Mouse Art1 Protein, His-tagged | E.coli | N-His | Gln23-Cys325 |
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| Cynomolgus Monkey | ART1-1214C | Recombinant Cynomolgus ART1 Protein, His-tagged | HEK293 | His |
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| Chicken | ART1-3284C | Recombinant Chicken ART1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ART1 Related Articles
ART1 involved in several pathways and played different roles in them. We selected most pathways ART1 participated on our site, such as Alpha-defensins, Defensins, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with ART1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alpha-defensins | DEFA5;DEFA1;DEFA6;ART1;DEFA3 |
| Defensins | DEFB119;DEFB104A;DEFB125;DEFA3;DEFA1;DEFB106A;DEFA6;DEFB116;ART1 |
| Immune System | LILRB4;ABI1B;CD96;UBR1;MASP2;NOD1;NCR3LG1;EIF4E3;BTR09 |
| Innate Immune System | NLRP4;CTSLL;PANX1;WASF3;IRAK3;FCN3;LAT2;TNIP2;ART1 |
ART1 has several biochemical functions, for example, NAD(P)+-protein-arginine ADP-ribosyltransferase activity, NAD+ ADP-ribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ART1 itself. We selected most functions ART1 had, and list some proteins which have the same functions with ART1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity | ART3;ART1;Art2b;ART5;CHAT2;MADPRT;CHAT1;SIRT6 |
| NAD+ ADP-ribosyltransferase activity | GIG2Q;TIPARP;CHAT1;PARP14;GIG2D;ART1;GIG2H;ZC3HAV1;PARP1 |
ART1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ART1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ART1.
- Q&As
- Reviews
Q&As (7)
Ask a questionART1 transfers ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to specific arginine residues on substrate proteins, modifying their structure and function.
ART1 predominantly ADP-ribosylates arginine residues on G protein-coupled receptors (GPCRs), such as the P2Y purinergic receptor.
Some pathogens produce enzymes called ADP-ribosyltransferase toxins that can inhibit ART1 activity and evade the immune response.
ART1 is primarily expressed in the testes, but it can also be found in other tissues such as the spleen, kidney, and liver.
Aside from its enzymatic role in ADP-ribosylation, ART1 does not have any known non-enzymatic functions or specific protein interactions.
Mutations in the ART1 gene have not been directly linked to specific diseases or disorders in humans so far.
The activity of ART1 is dependent on the presence of NAD+ as a substrate, and it can be modulated by other factors, including pH and the presence of certain ions.
Customer Reviews (3)
Write a reviewOne aspect that sets the ART1 protein apart is the excellent technical support provided by the manufacturer.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
The ART1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.
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