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Recombinant Human ART1 Protein, His-tagged

Cat.No. : ART1-2823H
Product Overview : Recombinant Human ART1 protein, fused to His-tagged at N-terminus, was expressed in E. coli.
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  • Gene Information
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Description : ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2.
Source : E. coli
Species : Human
Tag : His
Form : 50 mM Tris, 8 M Urea, pH 8.0
Molecular Mass : 36.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ART1 ADP-ribosyltransferase 1 [ Homo sapiens ]
Official Symbol : ART1
Synonyms : ART2; ARTC1; CD296; RT6
Gene ID : 417
mRNA Refseq : NM_004314
Protein Refseq : NP_004305
MIM : 601625
UniProt ID : P52961

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ART1 carry out ADP-ribosylation? 10/10/2022

ART1 transfers ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to specific arginine residues on substrate proteins, modifying their structure and function.

Are there any known substrates that ART1 acts upon? 01/22/2020

ART1 predominantly ADP-ribosylates arginine residues on G protein-coupled receptors (GPCRs), such as the P2Y purinergic receptor.

Are there any known natural inhibitors or regulators of ART1 activity? 07/31/2017

Some pathogens produce enzymes called ADP-ribosyltransferase toxins that can inhibit ART1 activity and evade the immune response.

In which tissues or organs is ART1 predominantly expressed? 07/29/2017

ART1 is primarily expressed in the testes, but it can also be found in other tissues such as the spleen, kidney, and liver.

Does ART1 have any non-enzymatic functions or interactions with other proteins? 01/07/2017

Aside from its enzymatic role in ADP-ribosylation, ART1 does not have any known non-enzymatic functions or specific protein interactions.

Are there any known diseases or disorders associated with mutations in the ART1 gene? 11/22/2016

Mutations in the ART1 gene have not been directly linked to specific diseases or disorders in humans so far.

Is the activity of ART1 influenced by any cofactors or regulators? 05/24/2016

The activity of ART1 is dependent on the presence of NAD+ as a substrate, and it can be modulated by other factors, including pH and the presence of certain ions.

Customer Reviews (3)

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Reviews
01/16/2022

    One aspect that sets the ART1 protein apart is the excellent technical support provided by the manufacturer.

    01/18/2020

      Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

      03/23/2016

        The ART1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

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