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Recombinant Human ART1 Protein, DYKDDDDK-tagged

Cat.No. : ART1-151H
Product Overview : Recombinant Human ADP-ribosyltransferase 1(ART1)(NM_004314), with a DYKDDDDK tag, was expressed in human cells.
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  • Gene Information
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Description : ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2.
Source : Human Cells
Species : Human
Tag : DYKDDDDK
Form : Purified protein formulated in a sterile solution of TBS buffer, pH7.182, without any preservatives.
Molecular Mass : 36.2 kDa
Endotoxin : Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
Purity : >90% by SDS-PAGE gel and Coomassie Blue staining
Applications : Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.
Gene Name : ART1 ADP-ribosyltransferase 1 [ Homo sapiens ]
Official Symbol : ART1
Synonyms : ART1; ADP-ribosyltransferase 1; GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; ART2; CD296; ADP-ribosyltransferase 2; mono(ADP-ribosyl)transferase 1; RT6; MGC133217;
Gene ID : 417
mRNA Refseq : NM_004314
Protein Refseq : NP_004305
MIM : 601625
UniProt ID : P52961

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does ART1 carry out ADP-ribosylation? 10/10/2022

ART1 transfers ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to specific arginine residues on substrate proteins, modifying their structure and function.

Are there any known substrates that ART1 acts upon? 01/22/2020

ART1 predominantly ADP-ribosylates arginine residues on G protein-coupled receptors (GPCRs), such as the P2Y purinergic receptor.

Are there any known natural inhibitors or regulators of ART1 activity? 07/31/2017

Some pathogens produce enzymes called ADP-ribosyltransferase toxins that can inhibit ART1 activity and evade the immune response.

In which tissues or organs is ART1 predominantly expressed? 07/29/2017

ART1 is primarily expressed in the testes, but it can also be found in other tissues such as the spleen, kidney, and liver.

Does ART1 have any non-enzymatic functions or interactions with other proteins? 01/07/2017

Aside from its enzymatic role in ADP-ribosylation, ART1 does not have any known non-enzymatic functions or specific protein interactions.

Are there any known diseases or disorders associated with mutations in the ART1 gene? 11/22/2016

Mutations in the ART1 gene have not been directly linked to specific diseases or disorders in humans so far.

Is the activity of ART1 influenced by any cofactors or regulators? 05/24/2016

The activity of ART1 is dependent on the presence of NAD+ as a substrate, and it can be modulated by other factors, including pH and the presence of certain ions.

Customer Reviews (3)

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Reviews
01/16/2022

    One aspect that sets the ART1 protein apart is the excellent technical support provided by the manufacturer.

    01/18/2020

      Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.

      03/23/2016

        The ART1 protein has demonstrated remarkable stability, allowing for extended storage without compromising its quality.

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