ASAH1 Protein, N-acylsphingosine amidohydrolase (acid ceramidase) 1

ASAH1

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ASAH1

Official Full Name N-acylsphingosine amidohydrolase (acid ceramidase) 1
Background This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.
Synonyms ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase) 1; ASAH, N acylsphingosine amidohydrolase (acid ceramidase); acid ceramidase; AC; FLJ21558; PHP32; acid CDase; acylsphingosine deacylase; putative 32 kDa heart protein; PHP; ASAH; ACDase; FLJ22079
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pan troglodytes (Chimpanzee)
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • SUMO
    • MYC/DDK
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse ASAH1-2093M Recombinant Mouse ASAH1 Protein (19-141 aa), His-GST-Myc-tagged E.coli His/GST/Myc
    Mouse Asah1-655M Recombinant Mouse Asah1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ASAH1-1134H Recombinant Human ASAH1 Protein, His-SUMO-tagged E.coli His/SUMO
    Human ASAH1-26424TH Recombinant Human ASAH1 Wheat Germ N/A
    Human ASAH1-2682H Recombinant Human ASAH1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ASAH1-524H Recombinant Human ASAH1 Protein, His-tagged E.coli His
    Human ASAH1-8670HCL Recombinant Human ASAH1 293 Cell Lysate HEK293 N/A
    Human ASAH1-878H Recombinant Human ASAH1 protein, GST-tagged Wheat Germ GST
    Human ASAH1-9909H Recombinant Human ASAH1, GST-tagged E.coli GST
    Rat ASAH1-814R Recombinant Rat ASAH1 Protein Mammalian Cell His
    Cynomolgus Monkey ASAH1-315C Recombinant Cynomolgus ASAH1 Protein, His-tagged Mammalian Cell His
    Chicken ASAH1-1593C Recombinant Chicken ASAH1 Mammalian Cell His
    Pan troglodytes (Chimpanzee) ASAH1-3066P Recombinant Pan troglodytes (Chimpanzee) ASAH1, His-tagged E.Coli or Yeast His

    ASAH1 involved in several pathways and played different roles in them. We selected most pathways ASAH1 participated on our site, such as Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid metabolism COL4A3BP; B4GALT6; VAPB; NEU3.4; SGPP2; GLA; PPAP2CB; ARSJ; SGMS2; ARSE
    Metabolic pathways AHCYL2; AKR1B7; PIP5K1BA; FBP1B; SCLY; UPB1; PNMT; PHYKPL; COX15; OCRL
    Sphingolipid signaling pathway GNAI1; SPHK1; KRAS; PPP2R3C; SMPD2; PPP2CA; TRP53; DEGS1; PPP2R5E; PRKCA
    Lysosome ATP6V0D2; PPT1; ARSB; DNASE2B; AP4M1; TCIRG1; NPC1; NAPSA; ATP6V0C; CLN5

    ASAH1 has several biochemical functions, for example, catalytic activity, ceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAH1 itself. We selected most functions ASAH1 had, and list some proteins which have the same functions with ASAH1. You can find most of the proteins on our site.

    Function Related Protein
    catalytic activity MOXD2; HSD17B6; RAG1; SYN1; CKBA; NANSA; ISOC2; ACSM2; MOSC2; CDYL
    ceramidase activity ACER1; ASAH1; ASAH1B; ASAH2

    ASAH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAH1.

    SRPK1; Bub1b; SETDB1; TSC22D1; CAMK1D; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; midostaurin; A2M; cona_canen

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