AXIN2 Protein, axin 2

AXIN2

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AXIN2

Official Full Name axin 2
Background The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Synonyms AXIN2; axin 2; AXIL; ODCRCS; axin-2; conductin; axin-like protein; axis inhibition protein 2;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AXIN2-10085H Recombinant Human AXIN2, GST-tagged E.coli GST
    Human AXIN2-1048H Recombinant Human AXIN2 protein, GST-tagged Wheat Germ GST
    Human AXIN2-3796H Recombinant Human AXIN2, His-tagged E.coli His
    Human AXIN2-391H Recombinant Human AXIN2 Protein, His-tagged E.coli His
    Human AXIN2-8554HCL Recombinant Human AXIN2 293 Cell Lysate HEK293 N/A
    Mouse AXIN2-2221M Recombinant Mouse AXIN2 Protein Mammalian Cell His
    Mouse Axin2-3794M Recombinant Mouse Axin2, His-tagged E.Coli or Yeast His
    Rat AXIN2-910R Recombinant Rat AXIN2 Protein Mammalian Cell His
    Chicken AXIN2-6061C Recombinant Chicken AXIN2 Mammalian Cell His
    Zebrafish AXIN2-9104Z Recombinant Zebrafish AXIN2 Mammalian Cell His

    AXIN2 involved in several pathways and played different roles in them. We selected most pathways AXIN2 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXIN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway CAMK2D2; NFATC3; TBL1XR1; FOSL1; APC; FZD8; DKK1; TCF7L1A; WNT7B; FZD3
    Hippo signaling pathway WNT16; SMAD7; AXIN1; STK3; WNT8B; DLG3; LATS1; BMP6; YWHAG; BMP2
    Signaling pathways regulating pluripotency of stem cells PIK3CB; WNT7A; KLF4; PCGF5; WNT4; INHBE; PCGF3; HAND1; NEUROG1; WNT9B
    Pathways in cancer IL6; WNT2; LAMA3; MSH3; NKX3; RALB; ABL1; EGLN1; PDGFB; KIT
    Colorectal cancer SMAD4; FOS; PIK3R3; TGFB1; TGFBR1; Casp3; CCND1; MAPK3; RHOA; ARAF
    Endometrial cancer PDPK1; TCF7L2; APC2; BAD; MAPK3; ARAF; TCF7; MAP2K2; PIK3CA; ELK1
    Basal cell carcinoma DVL1; FZD10; WNT4; WNT5A; HHIP; WNT9B; APC2; WNT3A; DVL3; FZD9

    AXIN2 has several biochemical functions, for example, GTPase activator activity, I-SMAD binding, armadillo repeat domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXIN2 itself. We selected most functions AXIN2 had, and list some proteins which have the same functions with AXIN2. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity RASAL3; TBC1D3C; RANBP1; RAP1GAP2B; GDI1; FAM13A; SRGAP3; CDC42EP3; CDC42EP5; ARHGAP27
    I-SMAD binding TGFB1I1; CTNNB1; SMAD7; SMAD1; SMAD4; SMAD2; AXIN2; AXIN1; SMAD6; TGFBR1
    armadillo repeat domain binding TCF7L2; STRN4; AXIN2; CNOT1; CTNNBIP1; LEF1; STRN; CHD8; AXIN1; CALCOCO1
    beta-catenin binding ESR1; BTRC; HDAC6; CD2AP; SMAD3; FAM123B; CDH5; GRIP1; LEF1; AXIN2
    enzyme binding HDAC3; CNTNAP2; UGT1A4; Alb; ADORA2A; NPM2; CLSTN2; CD40; PHB; BCHE
    protein binding GPATCH4; ADAMTSL5; MYRIP; ARPC3; NFE2L2; RNF20; L3MBTL2; CREBBP; ZNHIT1; IFI35
    protein kinase binding MAP2K3; PDPK1; CDK5RAP3; NCS1; FBXO5; CASP9; KCNA5; TP73; PTPN6; PTPRC
    ubiquitin protein ligase binding UBE2A; HERC2; UBOX5; CASP10; GABARAP; MFN2; BID; KDM4A; CUL1; PCBP2

    AXIN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXIN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AXIN2.

    PPP2CB; GSK3B; AMER3; AMMECR1; CDC20; FBP2; ZNF189; TGFB1; NS; FBP1; RANGAP1; PRDX1; SMAD1; HEMGN

    Valenti, F; Ibetti, J; et al. The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype. JOURNAL OF CELLULAR BIOCHEMISTRY 116:418-430(2015).
    Mastri, M; Shah, Z; et al. Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C531-C539(2014).

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