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AXIN2

Official Full Name

axin 2
Overview

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Synonyms

AXIN2; axin 2; AXIL; ODCRCS; axin-2; conductin; axin-like protein; axis inhibition protein 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
E.Coli or Yeast
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	AXIN2-10085H	Recombinant Human AXIN2, GST-tagged	E.coli	GST	30-83a.a.	$319 / 25ug
Human	AXIN2-3796H	Recombinant Human AXIN2, His-tagged	E.coli	His	843	Inquiry
Human	AXIN2-1048H	Recombinant Human AXIN2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	AXIN2-8554HCL	Recombinant Human AXIN2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	AXIN2-391H	Recombinant Human AXIN2 Protein, His-tagged	E.coli	His	Pro350~Lys631	Inquiry
Human	AXIN2-1066HF	Recombinant Full Length Human AXIN2 Protein, GST-tagged	In Vitro Cell Free System	GST	160 amino acids	Inquiry
Mouse	AXIN2-2221M	Recombinant Mouse AXIN2 Protein	Mammalian Cell	His		Inquiry
Mouse	Axin2-3794M	Recombinant Mouse Axin2, His-tagged	E.Coli or Yeast	His	840	Inquiry
Mouse	AXIN2-917M	Recombinant Mouse AXIN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	AXIN2-917M-B	Recombinant Mouse AXIN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	AXIN2-910R	Recombinant Rat AXIN2 Protein	Mammalian Cell	His		Inquiry
Rat	AXIN2-566R-B	Recombinant Rat AXIN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	AXIN2-566R	Recombinant Rat AXIN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	AXIN2-9104Z	Recombinant Zebrafish AXIN2	Mammalian Cell	His		Inquiry
Chicken	AXIN2-6061C	Recombinant Chicken AXIN2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
AXIN2 Related Articles

AXIN2 involved in several pathways and played different roles in them. We selected most pathways AXIN2 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXIN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Wnt signaling pathway	PRKCG;PPP3CC;CACYBP;NFATC2;TLE3A;WNT7A;TRP53;WNT2;FZD7B
Hippo signaling pathway	WNT2B;YAP1;FZD5;SMAD1;NKD1;DLG3;SERPINE1;SMAD7;TGFBR1
Signaling pathways regulating pluripotency of stem cells	MAPK1;IGF1R;FZD6;FZD8;LHX5;Fzd4;INHBB;GRB2;AKT1
Pathways in cancer	VEGFB;CCDC6;FASLG;FGF21;ITGA2;TGFBR2;NRAS;FGF6;FZD9
Colorectal cancer	RAC2;MLH1;PIK3CB;AXIN1;TRP53;RALGDS;MSH6;TGFB3;DCC
Endometrial cancer	ILK;AKT2;PIK3CB;LEF1;CCND1;AXIN1;PTEN;SOS1;ERBB2
Basal cell carcinoma	WNT6;FZD6;WNT9A;Fzd4;FZD8;GLI2;DVL2;WNT11;FZD2

AXIN2 has several biochemical functions, for example, GTPase activator activity, I-SMAD binding, armadillo repeat domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXIN2 itself. We selected most functions AXIN2 had, and list some proteins which have the same functions with AXIN2. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	GIT2B;ARHGEF15;SRGAP1;RGS17;RGS2;TBC1D24;TBC1D13;RALGAPA1;RALGAPA2
I-SMAD binding	TGFB1I1;SMAD2;SMAD4;AXIN2;SMAD1;SMURF1;SMAD7;AXIN1;CTNNB1
armadillo repeat domain binding	CALCOCO1;CTNNBIP1;CNOT1;TCF7L2;STRN4;CHD8;LEF1;AXIN1;STRN
beta-catenin binding	GSK3B;KDM6B;FAM123B;RORA;CD2AP;BCL9;TCF7;DACT2;TCF7L1B
enzyme binding	UBE2L3;CAV1;EGFR;CYP1A2;ZNF346;RCOR3;GOLPH3;CCND1;STC2
protein binding	SIGLEC6;SFMBT1;MSX2;CSRNP1;Tnfrsf23;RAD52;SLC25A10;ETV1;PPP1R15B
protein kinase binding	FAM83D;RPS3;PDCD10;FAF1;NEK9;GATA4;ERRFI1;ATP1A1;CCNL1A
ubiquitin protein ligase binding	TRIB2;AMBRA1;CALR;FANCL;UBE2Z;PRKACB;UBE2A;SPG20;PCBP2

AXIN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXIN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AXIN2.

PPP2CB; GSK3B; AMER3; AMMECR1; CDC20; FBP2; ZNF189; TGFB1; NS; FBP1; RANGAP1; PRDX1; SMAD1; HEMGN

Valenti, F; Ibetti, J; et al. The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype. JOURNAL OF CELLULAR BIOCHEMISTRY 116:418-430(2015).

Mastri, M; Shah, Z; et al. Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 306:C531-C539(2014).