Recombinant Human AXIN2 protein, GST-tagged
Cat.No. : | AXIN2-1048H |
Product Overview : | Human AXIN2 full-length ORF ( AAH06295.1, 1 a.a. - 160 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 44.4 kDa |
AA Sequence : | MSSAMLVTCLPDPSSSFREDAPRPP VPGEEGETPPCQPGVGKGQVTKPMP VSSNTRRNEDGLGEPEGRASPDSPL TRWTKSLHSLLGDQDGAYLFRTFLE REKCVDTLDFWFACNGFRQMNLKDT KTLRVANDFCHDILFYLYCKLCIIK SSFKENYLVQ |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AXIN2 axin 2 [ Homo sapiens ] |
Official Symbol : | AXIN2 |
Synonyms : | AXIN2; axin 2; axin-2; axil; conductin; DKFZp781B0869; MGC126582; axin-like protein; axis inhibition protein 2; AXIL; MGC10366; |
Gene ID : | 8313 |
mRNA Refseq : | NM_004655 |
Protein Refseq : | NP_004646 |
MIM : | 604025 |
UniProt ID : | Q9Y2T1 |
Products Types
◆ Recombinant Protein | ||
AXIN2-566R | Recombinant Rat AXIN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AXIN2-917M | Recombinant Mouse AXIN2 Protein, His (Fc)-Avi-tagged | +Inquiry |
AXIN2-391H | Recombinant Human AXIN2 Protein, His-tagged | +Inquiry |
AXIN2-3796H | Recombinant Human AXIN2, His-tagged | +Inquiry |
AXIN2-9104Z | Recombinant Zebrafish AXIN2 | +Inquiry |
◆ Lysates | ||
AXIN2-8554HCL | Recombinant Human AXIN2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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