Recombinant Full Length Human AXIN2 Protein, GST-tagged

• Cat.No.: AXIN2-1066HF
• Product Overview: Human AXIN2 full-length ORF ( AAH06295.1, 1 a.a. - 160 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 44.4 kDa
• Protein Length: 160 amino acids
• AA Sequence: MSSAMLVTCL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGQVTKPMP VSSNTRRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM NLKDTKTLRV ANDFCHDILF YLYCKLCIIK SSFKENYLVQ
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AXIN2 axin 2 [ Homo sapiens ]
• Official Symbol: AXIN2
• Synonyms: AXIN2; axin 2; axin-2; axil; conductin; DKFZp781B0869; MGC126582; axin-like protein; axis inhibition protein 2; AXIL; MGC10366
• Gene ID: 8313
• mRNA Refseq: NM_004655
• Protein Refseq: NP_004646
• MIM: 604025
• UniProt ID: Q9Y2T1