acta1
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  • Official Full Name
  • actin, alpha 1, skeletal muscle
  • Background
  • The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
  • Synonyms
  • ACTA1; actin, alpha 1, skeletal muscle; ACTA; actin, alpha skeletal muscle; alpha-actin-1; alpha skeletal muscle actin; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM
Cat.#:ACTA1-304HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ACTA1 Protein (3-377 aa), His-tagged
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Cat.#:ACTA1 -125HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACTA1 protein, GST-tagged
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Cat.#:ACTA1-1238MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ACTA1 Protein
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Cat.#:Acta1-3091RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Acta1, His-tagged
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Cat.#:ACTA1-477RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACTA1 Protein
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Cat.#:ACTA1-3090BTag:His
Source (Host):Mammalian CellsSpecies:Bovine
Product nameRecombinant Bovine ACTA1, His-tagged
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Cat.#:ACTA1-2743CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACTA1
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Cat.#:Acta1-158MTag:
Source (Host):Species:Mouse
Product nameNative Mouse skeletal muscle alpha Actin
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Cat.#:ACTA1-157RTag:
Source (Host):Species:Rabbit
Product nameNative Rabbit skeletal muscle alpha Actin
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Cat.#:ACTA1-853RTag:
Source (Host):Rabbit skeletal muscleSpecies:Rabbit
Product nameNative Rabbit ACTA1 Protein
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Cat.#:ACTA1-854PTag:
Source (Host):Porcine skeletal muscleSpecies:Porcine
Product nameNative Porcine ACTA1 Protein
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Cat.#:ACTA1-7HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACTA1 lysate
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Involved Pathway

ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis, Hypothetical Network for Drug Addiction, Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Caspase cascade in apoptosis
CASP4; DFFA; NUMA1; PARP1; CASP2; DIABLO; CRADD; LMNB1; GAS2; ACTA1
Hypothetical Network for Drug Addiction
ZHX2; CX28.8; NISCH; TERF2IP; ACTA1; GJB7; ACTA1B
Myometrial Relaxation and Contraction Pathways
GABPA; CNN1; RGS6; RGS4; ADM; RGS14; RGS20; RGS7; PKIG; RAMP3
RhoA signaling pathway
CYR61; ACTA1; DIAPH1; MKL1
Signaling events mediated by focal adhesion kinase
KLF8; ARHGEF28; ARHGAP26; ACTA1; BMX
Striated Muscle Contraction
DES; MYBPC3; MYBPC2; MYBPC2B; CMLC1; TNNI1; MYL1; SMYHC2; ACTA1B; MYLZ3

Protein Function

ACTA1 has several biochemical functions, for example, ADP binding, ATP binding, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein GLUD2; MYH10; MYH9; PRKAG2; ADCK3; GLUD1; ABCG1; TAP1; MIEF1; ERN1
Function ATP binding
Related Protein KIF6; DDX19B; UHMK1; PANK1B; OBSCN; DHX57; PFKFB4; SPATA5L1; AKT1; OXSR1A
Function myosin binding
Related Protein USH2A; SLC6A4; VEZT; ACTC1; ACTA1; ARFGEF1; FXYD1; CALM; DMD; ARFGEF2
Function protein binding
Related Protein TXLNA; TMPRSS7; AMPH; NKG7; CD79A; RAB1; SMOC1; FAM122A; PRMT5; RPS6KA1
Function structural constituent of cytoskeleton
Related Protein TUBA1B; TUBG1; TUBA3C; ACTL6B; TUBGCP5; ACTL7A; AGRN; TUBB6; KRT17; KRT14

Interacting Protein

ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.
HTRA2; DNASE1; GC; GSN; ssh-2; Kcnma1; SSH3; SSH1; ZNF16; TNNI3K; TRIM63; RNF167; SMURF2; CD247; ARRB1; BTK; LRRK2; TRAF3IP1; LRCH3

ACTA1 Related Articles

Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
Nakagawa, Y; Inoue, H; et al. Molecular biological analysis of cardiac effect of high temperature in rats. LEGAL MEDICINE 14:63-68(2012).