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ACTA1

  • Official Full Name

    actin, alpha 1, skeletal muscle

  • Overview

    The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
  • Synonyms

    ACTA1; actin, alpha 1, skeletal muscle; ACTA; actin, alpha skeletal muscle; alpha-actin-1; alpha skeletal muscle actin; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Porcine
  • Rabbit
  • Rat
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Pigeon Serum
  • Porcine skeletal muscle
  • Rabbit skeletal muscle
  • Rat Serum
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACTA1 -125H Recombinant Human ACTA1 protein, GST-tagged Wheat Germ GST
Human ACTA1-7HCL Recombinant Human ACTA1 lysate HEK293 N/A
Human ACTA1-304H Recombinant Human ACTA1 Protein (3-377 aa), His-tagged E.coli His 3-377 aa
Human ACTA1-306H Recombinant Human ACTA1 protein, GST-tagged E.coli GST 1-377 aa
Human ACTA1-305H Recombinant Human ACTA1 protein, His-tagged E. coli His 1-377 aa
Mouse ACTA1-1238M Recombinant Mouse ACTA1 Protein Mammalian Cell His
Mouse Acta1-158M Native Mouse skeletal muscle alpha Actin Pigeon Serum N/A Full length native mouse skeletal muscle alpha Actin
Mouse ACTA1-281M Recombinant Mouse ACTA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ACTA1-281M-B Recombinant Mouse ACTA1 Protein Pre-coupled Magnetic Beads HEK293
Rat Acta1-3091R Recombinant Rat Acta1, His-tagged E.Coli or Yeast His 377
Rat ACTA1-477R Recombinant Rat ACTA1 Protein Mammalian Cell His
Rat ACTA1-133R-B Recombinant Rat ACTA1 Protein Pre-coupled Magnetic Beads HEK293
Rat ACTA1-133R Recombinant Rat ACTA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit ACTA1-853R Native Rabbit ACTA1 Protein Rabbit skeletal muscle N/A 375 amino acids
Rabbit ACTA1-157R Native Rabbit skeletal muscle alpha Actin Rat Serum N/A Full length native Rabbit skeletal muscle alpha Actin
Bovine ACTA1-3090B Recombinant Bovine ACTA1, His-tagged E.Coli or Yeast His 377
Porcine ACTA1-854P Native Porcine ACTA1 Protein Porcine skeletal muscle N/A 375 amino acids
Chicken ACTA1-2743C Recombinant Chicken ACTA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACTA1 Related Articles

ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis, Hypothetical Network for Drug Addiction, Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Caspase cascade in apoptosisNUMA1;DFFA;SATB1;CRADD;TFAP2A;GAS2;LMNB1;TOP1;CASP2
Hypothetical Network for Drug AddictionACTA1;CX28.8;ZHX2;ACTA1B;NISCH;GJB7;TERF2IP
Myometrial Relaxation and Contraction PathwaysRAMP1;IGFBP4;RGS11;CNN1;RGS7;RGS16;RAMP2;GABPB1;GUCA2A
RhoA signaling pathwayCYR61;DIAPH1;ACTA1;MKL1
Signaling events mediated by focal adhesion kinaseBMX;ARHGEF28;ARHGAP26;ACTA1;KLF8
Striated Muscle ContractionTMOD2;TMOD1;TNNI2B.1;TNNI1B;MYBPC2A;TMOD4;TNNI2;MYBPC2;DES

ACTA1 has several biochemical functions, for example, ADP binding, ATP binding, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingGLUD2;PRPS2;PRPS1;MYO6;MYH10;ACTA1;MYO18A;CHORDC1;MYO9B
ATP bindingFIGNL2;SARS2;PMS2;CMPK;TTLL6;OASL;PLK1;CKMA;GLYCTK
myosin bindingSTX4A;SMYD1B;CALM;VAMP2;CALD1B;DMD;KIRREL;ACTA1;ARFGEF2
protein bindingTUBA4A;FIG4;DSN1;IRF6;RTP3;DCP1B;SIX5;SAMD4A;NCBP1
structural constituent of cytoskeletonKRT14;TUBB6;TLN2A;TUBB;ATXN1;BFSP1;KRT6B;KRT20;TUBA2

ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.

HTRA2; DNASE1; GC; GSN; ssh-2; Kcnma1; SSH3; SSH1; ZNF16; TNNI3K; TRIM63; RNF167; SMURF2; CD247; ARRB1; BTK; LRRK2; TRAF3IP1; LRCH3

Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
Nakagawa, Y; Inoue, H; et al. Molecular biological analysis of cardiac effect of high temperature in rats. LEGAL MEDICINE 14:63-68(2012).
  • Q&As
  • Reviews

Q&As (20)

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What were the findings when transgenic mice expressing ACTA1(D286G) were created? 12/04/2022

The Tg(ACTA1)(D286G) mice exhibited decreased activity levels, weaker skeletal muscles, and pathological lesions similar to those observed in human patients. However, unlike the patients, the mice had a normal lifespan.

What is the function of the ACTA1 protein? 07/11/2022

The ACTA1 protein, also known as skeletal muscle α-actin, plays a crucial role in muscle contraction and the maintenance of muscle structure. It is a key component of the sarcomeres, the structural units of muscle fibers.

What significance do the ringbinden fibers have in relation to ACTA1 mutations? 04/10/2022

The presence of ringbinden fibers in the mouse models suggests that patients with ringbinden fibers of unknown genetic origin should be considered for ACTA1 mutation screening, indicating a possible link between these features and ACTA1 mutations.

How is ACTA1 inhibited by PAX3-FOXO1 in ARMS? 01/25/2022

ACTA1 is inhibited by PAX3-FOXO1 both at the transcriptional level and the protein level. This inhibition occurs through the RhoA-MKL1-SRF signaling pathway.

What techniques can be used to study the ACTA1 protein? 12/18/2021

Researchers employ various techniques to study the ACTA1 protein, such as immunohistochemistry, immunoblotting, and mass spectrometry. These methods help identify the presence, abundance, and localization of ACTA1 in muscle tissues or cells.

How do mutations in the ACTA1 gene contribute to Nemaline myopathy (NM)? 06/06/2021

Mutations in the ACTA1 gene account for a significant proportion of NM cases. Most of these mutations are missense mutations, which cause autosomal dominant NM by producing an abnormal protein. However, about 10% of ACTA1 gene mutations are associated with autosomal recessive NM, resulting in loss of protein function.

Are there any known interacting proteins or partners of ACTA1? 01/13/2021

Yes, the ACTA1 protein interacts with other proteins involved in muscle function and structure. For example, it forms complexes with other actin-binding proteins, such as myosin and tropomyosin, to regulate muscle contraction.

What is the relationship between mutations in the ACTA1 gene and congenital myopathies? 08/06/2020

Mutations in the skeletal muscle α-actin gene (ACTA1) cause various congenital myopathies, resulting in severe skeletal muscle weakness in most patients.

What is the difference in inheritance patterns between dominant and recessive ACTA1 gene mutations? 05/23/2020

The majority of ACTA1 gene mutations cause autosomal dominant NM, meaning a single abnormal copy of the gene is sufficient to cause the disorder. In contrast, approximately 10% of ACTA1 gene mutations lead to autosomal recessive NM, requiring two copies of the mutated gene (one from each parent) to manifest the disorder.

How does the RhoA-MKL1-SRF signaling pathway impact the inhibition of ACTA1? 04/03/2020

The RhoA-MKL1-SRF signaling pathway is involved in mediating the inhibition of ACTA1 by PAX3-FOXO1. It is a signaling cascade that transmits the inhibitory signals from PAX3-FOXO1 to downregulate the expression of ACTA1.

 How is the ACTA1 protein normally regulated in skeletal muscle? 03/12/2020

The expression and regulation of the ACTA1 protein in skeletal muscle are tightly controlled by various molecular mechanisms, including transcriptional and post-transcriptional processes. These mechanisms ensure proper levels of ACTA1 for muscle function.

What protein composition was observed in the skeletal muscles of Tg(ACTA1)(D286G) mice? 02/10/2020

Mass spectrometry analysis revealed that the skeletal muscles of Tg(ACTA1)(D286G) mice contained approximately 25% of the ACTA1(D286G) protein.

How do ACTA1 mutations affect muscle structure? 01/29/2020

CTA1 mutations can disrupt the normal organization of muscle fibers and sarcomeres, leading to structural abnormalities. These abnormalities can include the presence of nemaline bodies, actin accumulations, and widespread sarcomeric disarray.

What happens when there are mutations in the ACTA1 gene? 12/07/2019

Mutations in the ACTA1 gene can lead to various congenital myopathies, which are muscle disorders present from birth or early infancy. These mutations can disrupt the normal function and structure of skeletal muscles.

What are some of the consequences of ACTA1 mutations? 07/21/2018

ACTA1 mutations can result in severe skeletal muscle weakness, leading to difficulties in movement and muscle function. In some cases, the severity of the mutations can be life-threatening, causing reduced lifespan and early mortality, as seen in certain dominant ACTA1 mutations.

Are there different types of ACTA1 mutations? 04/08/2018

 Yes, there are various types of ACTA1 mutations identified in patients with congenital myopathies. These mutations can have different effects on the structure and function of the ACTA1 protein, leading to a spectrum of clinical presentations and disease severity.

 What is the potential therapeutic implication related to ACTA1 protein load? 04/19/2017

Studies have suggested that altering the ratio of mutant ACTA1 protein to wild-type actin protein in patient muscles may hold promise as a potential therapy for patients with dominant ACTA1 disease

Where is the ACTA1 protein primarily found? 02/06/2017

The ACTA1 protein is primarily found in skeletal muscle, which is responsible for voluntary muscle movement in the body.

What is the significance of the inhibition of ACTA1 by PAX3-FOXO1? 01/06/2016

The inhibition of ACTA1 by PAX3-FOXO1 is believed to play a role in the tumorigenesis and development of alveolar rhabdomyosarcoma (ARMS). It suggests that this regulatory mechanism contributes to the disease progression.

What potential therapy is suggested based on the correlation between mutant ACTA1 protein load and disease severity? 01/02/2016

Altering the ratio of mutant ACTA1 protein to wild-type actin in patient muscle may be a potential therapy for patients with dominant ACTA1 disease.

Customer Reviews (5)

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Reviews
12/25/2021

    I found the protein product to be highly stable, retaining its functionality even after months of storage, which was crucial for my long-term experiments

    05/11/2021

      The protein product's reliable performance and consistent quality reassured me that it would not introduce any confounding factors or jeopardize the integrity of my experiments.

      04/24/2018

        I found the protein product to be compatible with various downstream applications, such as Western blotting and ELISA, broadening its utility in my researc

        07/12/2017

          I appreciated the convenient packaging of the protein product, with individual aliquots that reduced the need for repeated thawing and freezing.

          11/12/2016

            I appreciated the protein product's consistent performance at the specified concentrations, enabling me to achieve accurate dosing in my experiments

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