APC
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Official Full Name
adenomatous polyposis coli
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Overview
Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates beta-catenin via interactions with Axin/GSK3-beta complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration. -
Synonyms
APC; adenomatous polyposis coli; adenomatosis polyposis coli; adenomatous polyposis coli protein; DP2; DP2.5; DP3; PPP1R46; protein phosphatase 1; regulatory subunit 46; deleted in polyposis 2.5; adenomatosis polyposis coli tumor suppressor; protein phosphatase 1, regulatory subunit 46; GS; BTPS2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- Human Plasma
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- T7
- N/A
- N
- SUMO
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- APC Related Articles
- APC Related Signal Pathway
APC involved in several pathways and played different roles in them. We selected most pathways APC participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with APC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Wnt signaling pathway | FBXW2;DKK1;NKD2B;MYCB;CAMK2D1;TBL1X;FZD7B;WNT11R;APC |
| Hippo signaling pathway | TP73;WWTR1;PARD6B;Fzd4;SMAD7;DVL3;FZD7;LLGL2;CRB1 |
| Signaling pathways regulating pluripotency of stem cells | OTX1;SMAD2;ACVR2B;ISL1;ID2;AKT1;MAP2K1;FZD1;FZD5 |
| Regulation of actin cytoskeleton | DIAPH1;MAP2K1;NRAS;PDGFRB;FGFR1A;ITGA7;ARPC5L;FGFR2;FGF6B |
| HTLV-I infection | TERT;ZFP36;ANAPC1;IKBKB;CRTC2;TCF3;H2-Q10;HLA-C;DLG1 |
| Pathways in cancer | LPAR6;EGLN2;RUNX1;BDKRB2;VHL;FN1;RALGDS;KITLG;NFKBIA |
| MicroRNAs in cancer | PRKCE;NOTCH1;BAK1;TIMP3;APC2;FSCN1;MTOR;SIRT1;CCND2 |
| Colorectal cancer | TGFBR1;MSH3;MLH1;GSK3B;CYCS;RHOA;CCND1;RAF1;MAPK10 |
| Endometrial cancer | AKT2;ARAF;KRAS;CCND1;AXIN2;APC;PIK3CD;LEF1;TRP53 |
| Basal cell carcinoma | Fzd4;TP53;WNT9B;TCF7L2;FZD10;WNT10B;WNT8B;AXIN2;FZD9 |
APC has several biochemical functions, for example, beta-catenin binding, NOT cadherin binding, gamma-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APC itself. We selected most functions APC had, and list some proteins which have the same functions with APC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | LEF1;RORA;CDH2;TCF7L1A;TBL1XR1;CTNNBIP1;TCF7L2;CD2AP;PROP1 |
| NOT cadherin binding | |
| gamma-catenin binding | DSG1A;DSG1;CDH1;PTBP3;APC;LEF1;PTPRK;PTPRJ;TCF7L2 |
| microtubule binding | CRYAB;PLK1;FAM83D;EZR;FTCD;GOLGA2;RAB11A;CKAP5;SPAST |
| microtubule plus-end binding | DST;CLIP1;APC;KIF2C;STIM1;CLASP1;MAPRE1;KIF18A;CLASP1A |
| protein binding | UCHL3;CCP110;SLC9A1;TIA1;PLEKHA2;GTF2E1;PPP1R13L;SMAD4;LSM10 |
| protein kinase binding | PRKAB1;TPX2;RFFL;GATA6;PARN;RAB8A;ACTA2;SV2A;CDC25C |
| protein kinase regulator activity | KIDINS220;CDC37;KIDINS220B;APC;FAF1;CDK5RAP1;ANKRD54;CSNK2B;RAC2 |
APC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APC here. Most of them are supplied by our site. Hope this information will be useful for your research of APC.
CTNNB1; MAPRE1
- Q&As
- Reviews
Q&As (20)
Ask a questionThe source of Apc is the genome of E. coli and other bacteria, and it is artificially prepared by recombinant technology.
Patients should be closely monitored during the use of Apc , and sudden adverse reactions should be stopped in time and treated accordingly.
The therapeutic mechanism of Apc is to achieve therapeutic effect by activating the internal normal repair mechanism of intestinal epithelial cells, which is different from the therapeutic mechanism of anti-inflammatory drugs.
Apc is more reliable and has fewer side effects than other treatments, and has more obvious efficacy.
The application prospect of Apc is very broad, and there is still a lot of room for development and application scenarios in the future.
The price of Apc varies according to different countries, regions and manufacturers, and there are generally specific prices for different levels.
The clinical trial of Apc involves the research scope and methods mainly including drug safety, drug dose and frequency of use, therapeutic effect and serum biology.
The methods to ensure the quality of Apc mainly include the GMP production management system and quality testing system of drug manufacturers.
The treatment effect of Apc varies from patient to patient and generally takes weeks or even months to show up.
Apc has good safety, clinical studies have found a low rate of side effects, and serious adverse reactions are extremely rare.
Apc therapy is mainly suitable for patients with related diseases such as colorectal cancer and inflammatory bowel disease.
Apc can cause immune response, but in a certain dose and use mode, can reduce the incidence of immune reaction.
The future research directions and challenges of Apc mainly include the improvement of drug dosage forms, the further improvement of efficacy and safety, and the reliability of clinical trial design and result interpretation.
The course of treatment of Apc is generally not interfered with by other drugs, but patients should promptly inform their physician of other drugs used.
The production process of Apc mainly includes gene recombination process and protein purification process.
Apc can activate the internal normal repair mechanism of intestinal epithelial cells and reduce intestinal inflammatory response, so as to have a therapeutic effect on related diseases.
Recombinant Apc protein is mainly used to treat related diseases such as colorectal cancer and inflammatory bowel disease.
The dose and frequency of Apc are determined according to the patient's clinical situation and treatment regimen. The clinician will instruct the patient on the dosage and frequency of use based on standard treatment and monitoring indicators.
The treatment plan of Apc can be combined with other treatments, but the specific plan needs to be given by the doctor according to the specific situation of the patient.
Side effects such as mild fever and local pain may occur during treatment with Apc , but usually do not require special attention.
Customer Reviews (4)
Write a reviewI appreciate the production process of APC, every step is strictly controlled, thus ensuring the quality and stability of the product.
I appreciate the quality of APC manufacturer's attention to the product, and their product repeatability is very good, which makes our experiment more smooth.
APC produced by them has good labeling effect and can be used for fluorescent labeling.
The background of APC in Western blot was very clean and showed good antibody specificity.
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