Active Native Human Activated Protein C

• Cat.No.: APC-001H
• Product Overview: Native APC protein purified from human plasma.

Specification

• Description: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
• Source: Human Plasma
• Species: Human
• Form: 50% (vol/vol) Glycerol/H2O
• Bio-activity: Activity is measured using a chromogenic substrate assay.
• Molecular Mass: 56.2 kDa
• Purity: >95% by SDS-PAGE
• Storage: At -20 centigrade.

Gene Information

• Gene Name: APC APC, WNT signaling pathway regulator [ Homo sapiens (human) ]
• Official Symbol: APC
• Synonyms: GS; DP2; DP3; BTPS2; DP2.5; PPP1R46; adenomatous polyposis coli protein; WNT signaling pathway regulator; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli (APC); deleted in polyposis 2.5; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli
• Gene ID: 324
• mRNA Refseq: NM_000038
• Protein Refseq: NP_000029
• MIM: 611731
• UniProt ID: P25054