Recombinant Human APC protein, His-T7-tagged APC-02H

Recombinant Human APC protein, His-T7-tagged

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Recombinant Human APC protein, His-T7-tagged

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Cat.No. : APC-02H
Product Overview : Recombinant Human APC protein(Accession#P25054)(Ala2634~Val2843) was expressed in E. coli with two N-terminal Tags, His-tag and T7-tag.
Description : This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Source : E. coli
Species : Human
Tag : His-T7
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Molecular Mass : 26.2kDa
Protein length : Ala2634~Val2843
AA Sequence : MGSSHHHHHHSSGLV PRGSHMASMTGGQQM GRGSEFATNGAESKT LIYQMAPAVSKTEDV WVRIEDCPINNPRSG RSPTGNTPPVIDSVS EKANPNIKDSKDNQA KQNVGNGSVPMRTVG LENRLNSFIQVDAPD QKGTEIKPGQNNPVP VSETNESSIVERTPF SSSSSSKHSSPSGTV AARVTPFNYNPSPRK SSADSTSARPSQIPT PVNNNTKKRDSKTDS TESSGTQSPKRHSGS YLVTSV
Endotoxin : <1.0 EU per μg protein as determined by the LAL method.
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
SDS-PAGE of APC-02H :

Gene Name : APC
Official Symbol : APC
Synonyms : DP2; DP2.5; DP3; FAP; FPC; GS; Deleted in polyposis 2.5
Gene ID : 324
mRNA Refseq : NM_000038.6
Protein Refseq : NP_000029.2
MIM : 611731
UniProt ID : P25054

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