b4galt2
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  • Official Full Name
  • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
  • Background
  • This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms
  • B4GALT2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2; beta-1,4-galactosyltransferase 2; beta4Gal T2; Beta 1,4 galactosyltransferase 2; B4Gal T2; Beta 1,4 GalTase 2; Beta 4 GalT2; Beta N acetylglucosaminyl glycolipid beta 1,4 galactosyltransferase 2; UDP Gal:beta GlcNAc beta 1,4 galactosyltransferase 2; UDP Gal:betaGlcNAc beta 1,4 galactosyltransferase polypeptide 2; UDP galactose:beta N acetylglucosamine beta 1,4 galactosyltransferase 2; beta-4-GalT2; beta-1,4-GalTase 2; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; B4Gal-T2; B4Gal-T3; beta4Gal-T2
Cat.#:B4GALT2-029HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human B4GALT2 protein, GST-tagged
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Cat.#:B4GALT2-1008HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human B4GALT2 Protein, His-tagged
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Cat.#:B4GALT2-6757CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken B4GALT2
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Cat.#:B4GALT2-6886ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish B4GALT2
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Cat.#:B4GALT2-8539HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human B4GALT2 293 Cell Lysate
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Involved Pathway

B4GALT2 involved in several pathways and played different roles in them. We selected most pathways B4GALT2 participated on our site, such as Galactose metabolism, N-Glycan biosynthesis, Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with B4GALT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Galactose metabolism
HK3; PGM1; GANC; LALBA; GAA; PGM2; B4GALT2; PFKMA; G6PC; AKR1B8
N-Glycan biosynthesis
ALG1; MAN2A1; ST6GAL2A; MAN1C1; ST6GAL2; MGAT5; DOLPP1; MGAT4A; DPAGT1; TUSC3
Other types of O-glycan biosynthesis
MGAT5B; POMT1; GXYLT1B; B3GALT4; FUT4; FUT9A; GLT25D1; PLOD3; POMT2; C3orf64
Glycosaminoglycan biosynthesis - keratan sulfate
CHST1; FUT8; CHST2A; CHST2; ST3GAL3B; B3GNT7; B3GNT1; B4GALT1; ST3GAL2; B4GALT4
Glycosphingolipid biosynthesis - lacto and neolacto series
B3GALT5; B3GNT5A; B4GALT1; B3GNTL2; B3GALT1; ST3GAL6; FUT4; FUT7; ST3GAL3B; FUT9
Metabolic pathways
AGXTA; QPRT; GBA3; GCH1; UQCR10; OXSM; NANP; CYP51; TYMS; PPAP2D

Protein Function

B4GALT2 has several biochemical functions, for example, N-acetyllactosamine synthase activity, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by B4GALT2 itself. We selected most functions B4GALT2 had, and list some proteins which have the same functions with B4GALT2. You can find most of the proteins on our site.
Function
Related Protein
Function N-acetyllactosamine synthase activity
Related Protein B4GALT4; B4GALT1; B4GALT2; B4GALT3
Function beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
Related Protein B4GALT7; B4GALT2; WDFY3; B4GALT3; B4GALT1
Function galactosyltransferase activity
Related Protein B4GALT3; B3GNT7; B3GNT2A; B4GALT5; GTDC2; DPY19L4; B3GNT2; B3GNT5; POMGNT2; B3GNT7L
Function lactose synthase activity
Related Protein B4GALT1; B4GALT2; aLA; LALBA
Function metal ion binding
Related Protein HELZ2; ZFP526; UBE3A; ZNF394; NR1D4A; CHEK2; RC3H2; ATP8A1; RHEBL1; SMAD4

Interacting Protein

B4GALT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B4GALT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of B4GALT2.
PFDN6