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B4GALT2

Official Full Name

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
Overview

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms

B4GALT2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2; beta-1,4-galactosyltransferase 2; beta4Gal T2; Beta 1,4 galactosyltransferase 2; B4Gal T2; Beta 1,4 GalTase 2; Beta 4 GalT2; Beta N acetylglucosaminyl glycolipid beta 1,4 galactosyltransferase 2; UDP Gal:beta GlcNAc beta 1,4 galactosyltransferase 2; UDP Gal:betaGlcNAc beta 1,4 galactosyltransferase polypeptide 2; UDP galactose:beta N acetylglucosamine beta 1,4 galactosyltransferase 2; beta-4-GalT2; beta-1,4-GalTase 2; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2; B4Gal-T2; B4Gal-T3; beta4Gal-T2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Zebrafish

Source

E.coli expression system
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	B4GALT2-1008H	Active Recombinant Human B4GALT2 Protein, His-tagged	Mammalian cells	His	Ser43-Gly372	Inquiry
Human	B4GALT2-029H	Recombinant Human B4GALT2 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	B4GALT2-8539HCL	Recombinant Human B4GALT2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	B4GALT2-2528H-B	Recombinant Human B4GALT2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	B4GALT2-2528H	Recombinant Human B4GALT2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	B4GALT2-1653HF	Recombinant Full Length Human B4GALT2 Protein, GST-tagged	In Vitro Cell Free System	GST	306 amino acids	Inquiry
Mouse	B4galt2-11HCL	Recombinant Mouse B4galt2 overexpression lysate	HEK293T	Myc/DDK		Inquiry
Mouse	B4galt2-1807M	Recombinant Mouse B4galt2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	B4galt2-27HCL	Recombinant Mouse B4galt2 overexpression lysate	HEK293T	Myc/DDK		Inquiry
Homo sapiens (Human)	RFL18987HF	Recombinant Full Length Human Beta-1,4-Galactosyltransferase 2(B4Galt2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-372)	Inquiry
Zebrafish	B4GALT2-6886Z	Recombinant Zebrafish B4GALT2	Mammalian Cell	His		Inquiry
Chicken	B4GALT2-6757C	Recombinant Chicken B4GALT2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

B4GALT2 involved in several pathways and played different roles in them. We selected most pathways B4GALT2 participated on our site, such as Galactose metabolism, N-Glycan biosynthesis, Other types of O-glycan biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with B4GALT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Galactose metabolism	PGM1;G6PC2;PFKP;GLB1;G6PC;AKR1B7;PFKL;G6PCA.2;AKR1B8
N-Glycan biosynthesis	B4GALT2;MGAT4A;MGAT3;B4GALT3;DPM2;TUSC3;ALG5;ZNF408;MAN2A2
Other types of O-glycan biosynthesis	POFUT1;GXYLT2;LFNG;ST6GAL2;B3GAT2;B3GAT1;FUT7;ST6GAL1;POGLUT1
Glycosaminoglycan biosynthesis - keratan sulfate	FUT8;B3GNT1;B4GALT2;B3GNT2;B3GNT7;FUT8A;B4GALT1;ST3GAL2;CHST4
Glycosphingolipid biosynthesis - lacto and neolacto series	B4GALT2;B4GALT3;FUT3;B3GNT2;FUT4;ST3GAL3B;GGTA1;FUT7;B3GNT5
Metabolic pathways	SMPD2A;AGK;PTGDS;FUT5;NAGLU;NDUFB10;IDH3A;SQLE;AMY1A

B4GALT2 has several biochemical functions, for example, N-acetyllactosamine synthase activity, beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity, galactosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by B4GALT2 itself. We selected most functions B4GALT2 had, and list some proteins which have the same functions with B4GALT2. You can find most of the proteins on our site.

Function	Related Protein
N-acetyllactosamine synthase activity	B4GALT2;B4GALT3;B4GALT4;B4GALT1
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	B4GALT1;B4GALT3;B4GALT7;B4GALT2;WDFY3
galactosyltransferase activity	B3GNT8;DPY19L4;GTDC2;PIGB;B3GNT9-PS;GALNT18A;B3GALT6;A4GALT;B3GNT4
lactose synthase activity	aLA;B4GALT1;B4GALT2;LALBA
metal ion binding	ZC3H3;GIT2A;TDO2;ZNF48;CYB561A3A;TRIM50;MGAT1;POLM;TIMM8A2

B4GALT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B4GALT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of B4GALT2.

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