BMP1

  • Official Full Name

    bone morphogenetic protein 1
  • Overview

    This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
  • Synonyms

    BMP1;bone morphogenetic protein 1;PCP;TLD;OI13;PCP2;PCOLC;mammalian tolloid protein;procollagen C-proteinase 3;procollagen C-endopeptidase

Recombinant Proteins

  • Human
  • Mouse
  • Rhesus macaque
  • E.coli
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
BMP1-10247H Recombinant Human BMP1, His-tagged E.coli Human His 58-140a.a.
BMP1-26314TH Recombinant Human BMP1 protein, GST-tagged Wheat Germ Human GST 747-845 a.a.
BMP1-571H Active Recombinant Human Bone Morphogenetic Protein 1, His-tagged Mammalian Cells Human His 121-730 a.a.
BMP1-707H Active Recombinant Human BMP1, His-tagged Mammalian Cells Human His 121-730 a.a.
BMP1-2428M Recombinant Mouse BMP1 Protein Mammalian Cells Mouse His
BMP1-256H Recombinant Human BMP1 Protein, GST-tagged Wheat Germ Human GST
BMP1-546R Recombinant Rhesus monkey BMP1 Protein, His-tagged Mammalian Cells Rhesus macaque His
BMP1-662H Recombinant Human BMP1 protein, His & GST-tagged E.coli Human GST&His Glu610~Ser843
Bmp1-663M Recombinant Mouse Bmp1 protein, His-tagged E.coli Mouse His Gly856~Lys982
BMP1-8436HCL Recombinant Human BMP1 293 Cell Lysate HEK293 Human Non
BMP1-1050M Recombinant Mouse BMP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
BMP1-1050M-B Recombinant Mouse BMP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
BMP1-1734HF Recombinant Full Length Human BMP1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 622 amino acids
BMP1-2548H Recombinant Human BMP1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
BMP1-2548H-B Recombinant Human BMP1 Protein Pre-coupled Magnetic Beads HEK293 Human
BMP1-2595H Recombinant Human BMP1 protein, His-tagged E.coli Human His 121-986aa
BMP1-30198H Recombinant Human BMP1 protein, GST-tagged E.coli Human GST Leu1-Gly140
BMP1-374R Recombinant Rhesus Macaque BMP1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
BMP1-374R-B Recombinant Rhesus Macaque BMP1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Bmp1-4004M Recombinant Mouse Bmp1 Protein (Glu615-Ser848), N-GST tagged E.coli Mouse GST Glu615-Ser848

    Involved Pathway

    BMP1 involved in several pathways and played different roles in them. We selected most pathways BMP1 participated on our site, such as Adipogenesis,Anchoring fibril formation,Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Collagen formation COL5A1,CTSS,COL5A2,COL25A1,PCOLCEB,ADAMTS3,SERPINH1,CRTAP,SERPINH1A,P3H2
    Anchoring fibril formation BMP1A,BMP1B,TLL2,TLL1
    Crosslinking of collagen fibrils TLL1,BMP1B,LOXL2,BMP1A,LOXL1,PCOLCE,LOXL4,LOX,TLL2,LOXL3
    Adipogenesis BMP3,MEF2B,STIL,EBF1,SMAD3B,MBNL1,DVL1,EPAS1B,GDF10,FRZB
    Collagen biosynthesis and modifying enzymes COL5A2,EMID2,COL4A6,COL4A3,PRP,COL6A1,COL8A1A,PCOLCE2,COL3A1,COL25A1
    Degradation of the extracellular matrix MMP8,ADAM8,ADAM15,COL9A1,CTSLL,ADAMTS4,MGC174857,MMP15,MMP24,ADAMTS5
    Assembly of collagen fibrils and other multimeric structures COL11A1B,TLL1,BMP1B,COL5A1,COL5A3A,COL8A1,COL4A4,LOX,COL4A6,COL3A1
    Cardiac Progenitor Differentiation T,ROR2,SOX1,TBX5,NKX2,ZFP42,LIN28A,SIRPA,NIPAL1,TBX20

    Protein Function

    BMP1 has several biochemical functions, for example, calcium ion binding,cytokine activity,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BMP1 itself. We selected most functions BMP1 had, and list some proteins which have the same functions with BMP1. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CCL20B,TNFSF14,SCG2,SECTM1,IFNPHI2,IL36A,LFT2,TNFSF11,IFNL3,CSF1A
    growth factor activity GDF9,LFT2,FGF6B,CD320,Il2,CDNF,BMP7B,PSPN,CECR1,CXCL1
    metallopeptidase activity MMP25,CLCA3,NAALAD2,C6AST4,NPSN,DNPEP,ADAMTS13,PAPLNB,BRCC3,ADAM8A
    protein binding HIST1H2BE,RBMY1B,GZMM,KRTAP12-2,ARL2,PPAP2B,SCP2,USHBP1,ZNF652,NAT9
    metalloendopeptidase activity MMP10,ADAMTS8,MMP30,ADAM12,MMP26,ADAMTS13,MMP25,TLL2,ADAMTS2,ADAM23
    peptidase activity TMPRSS12,Adamts19,SPCS1,PSMB9A,Shh,AZU1,CTSB,HE1A,KEX2,TPP1
    calcium ion binding PVALB8,DSC2L,ANXA3A,S100U,EFHB,PCDHA9,OIT3,PCDH2G7,ANXA11A,SRI
    zinc ion binding TRIM60,RANBP2,ZZZ3,ARIH1,NR2F5,TRIM55A,RFWD3,RNF20,RFWD2,SUV39H2

    Interacting Protein

    BMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMP1.

    MSTN;CHRD;TP53;ADRA1A;YLPM1;GEM;Uso1

    Resources

    References

    • Purushotham, S; Deivanayagam, C; et al. Cloning, expression and purification of the SRCR domains of glycoprotein 340. PROTEIN EXPRESSION AND PURIFICATION 90:67-73(2013).
    • Grgurevic, L; Macek, B; et al. Bone morphogenetic protein (BMP)1-3 enhances bone repair. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 408:26-+(2011).

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