Active Recombinant Human Bone Morphogenetic Protein 1, His-tagged
Cat.No. : | BMP1-571H |
Product Overview : | Recombinant Human BMP1protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Ala121-Gln730. |
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Cat. No. : | BMP1-571H |
Description : | Bone morphogeneticprotein 1 (BMP1), also known as procollagen Cproteinase (PCP), is a zinc proteaseof the astacin family. BMP1/PCP plays a key role in formation ofextracellular matrix (ECM) by converting precursor proteins into their matureand functional forms. The precursor proteins identified as substrates forBMP1/PCP include collagens, biglycan, laminin 5, dentin matrix protein1, andlysyl oxidase. There are six alternatively spliced forms known to be derivedfrom the BMP1 gene, and isoform 1 consisting of residues 1 to 730 wasexpressed. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in HEPES, NaCl, CaCl2, ZnCl2and Brij-35. |
N-terminalSequence : | Ala121 |
Molecular Weight : | 70.5 kDa |
Activity : | Measured by itsability to cleave a fluorogenic peptide substrate, Mca-YVADAPK (Dnp)-OH. Thespecific activity is > 4 pmol/min/μg, as measured under the describedconditions. |
Endotoxin Level : | < 1.0EU per 1 μg of the protein by the LAL method. |
SDS-PAGE : | 84 kDa, reducingconditions. |
Purity : | > 95%, by SDSPAGEunder reducing conditions and visualized by silver stain. |
Reconstitution : | 100 μg/mL in sterile25 mM HEPES and 0.01% Brij-35, pH 7.5. |
Storage : | Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt,-20 to -70°C as supplied. 3 months, -20 to -70°C under sterile conditionsafter reconstitution. |
Protein length : | Ala121-Gln730 |
Gene Name : | BMP1 bone morphogenetic protein 1[ Homo sapiens ] |
Official Symbol : | BMP1 |
Synonyms : | BMP1; bonemorphogenetic protein 1; procollagen C-proteinase; mammalian tolloid protein;procollagen C-endopeptidase; BMP-1; PCP; PCOLC; mTId; EC 3.4.24.19 |
Gene ID : | 649 |
mRNA Refseq : | NM_001199 |
Protein Refseq : | NP_001190 |
MIM : | 112264 |
UniProt ID : | P13497 |
Chromosome Location : | 8p21 |
Pathway : | Adipogenesis;HDL-mediated lipid transport; Lipid digestion; Lipoprotein metabolism;Metabolism; Metabolism of lipids and lipoproteins |
Function : | calcium ion binding;cytokine activity; growth factor activity; metal ion binding;metalloendopeptidase activity; metallopeptidase activity; peptidase activity;zinc ion binding |
Products Types
◆ Recombinant Protein | ||
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BMP1-1050M | Recombinant Mouse BMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMP1-256H | Recombinant Human BMP1 Protein, GST-tagged | +Inquiry |
BMP1-26314TH | Recombinant Human BMP1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
BMP1-8436HCL | Recombinant Human BMP1 293 Cell Lysate | +Inquiry |
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Not For Human Consumption!
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