braf
Share
  • Official Full Name
  • v-raf murine sarcoma viral oncogene homolog B1
  • Background
  • The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three
  • Synonyms
  • BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9
Cat.#:BRAF-253HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BRAF, GST-tagged, Active
+Inquiry
Cat.#:BRAF-174HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-175HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
+Inquiry
Cat.#:BRAF-176HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
+Inquiry
Cat.#:BRAF-177HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-178HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-179HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-180HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-181HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-182HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-183HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-22HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
+Inquiry
Cat.#:BRAF-26566THTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF
+Inquiry
Cat.#:BRAF-26567THTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF
+Inquiry
Cat.#:BRAF-319HTag:GST/His
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-His-tagged
+Inquiry
Cat.#:BRAF-320HTag:GST
Source (Host):Sf21 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
+Inquiry
Cat.#:BRAF-321HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
+Inquiry
Cat.#:BRAF-550HTag:N-terminal His-tag (BRAF), N-terminal FLAG-tag (p50)
Source (Host):Insects cellSpecies:Human
Product nameRecombinant Human BRAF/p50 Protein, Flag-His-tagged
+Inquiry
Cat.#:BRAF-791HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BRAF protein, GST-tagged
+Inquiry
Cat.#:BRAF-2477MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BRAF Protein
+Inquiry
Cat.#:BRAF-6854CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BRAF
+Inquiry
Cat.#:BRAF-11759ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BRAF
+Inquiry
Cat.#:BRAF-994HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Raf Murine Sarcoma Viral Oncogene Homolog B1, GST-tagged
+Inquiry
Cat.#:BRAF-8414HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF 293 Cell Lysate
+Inquiry

Involved Pathway

BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RAP1AA; MAPK11; EGFRA; FGF1B; TGFBR2; NTRK2; CDC42; FGF2; MEF2CA; PAK2A
ErbB signaling pathway
NCK2A; EGFRA; PAK6; MAP2K2B; PIK3CD; NRG2B; SHC1; PAK2B; CDKN1BA; MAPK10
Rap signaling pathway
PDGFC; FGF19; F2RL3; PRKD3; CALM2; PLCG1; MAPK3; PARD3; PLCB4; GRIN2B
cAMP signaling pathway
ACOX3; VAV2; ATP2A2; PIK3R5; GRIA4; GABBR2; GNAI3; CALM1; CNGA3; PPARA
Chemokine signaling pathway
XCL1; CCL20; CCL22; PRKCZ; NFKBIA; PXN; GNGT2; CCL21B; CCR1L1; CCL3L1
FoxO signaling pathway
CDKN1BA; GRM1; SGK1; RAG2; HOMER2; PCK2; TGFB1A; SMAD3A; MAPK8; IRS2
mTOR signaling pathway
PIK3R3B; RRN3; STK11; PIK3CG; PTENB; RPS6KA3A; AKT1S1; AKT2; DDIT4; INS
Vascular smooth muscle contraction
GNA11A; PRKCA; RHOAD; CALM2; BRAF; ARHGEF1; CALD1B; AGTR1B; KCNMB1; PLA2G2F
Focal adhesion
RAF1A; PIK3R3B; THBS1; PIP5K1C; PTK2; MYLPF; ACTN2; RHOA; ITGA3; MYL2B
Natural killer cell mediated cytotoxicity
ICAM1; SH2D1B; ULBP2; KIR2DL3; FASLG; PTPN6; KIR2DL1; IFNA2; IFNA10; ULBP1
Long-term potentiation
MAPK1; PPP3CC; HRAS; ATF4; PPP1CC; GRIN2B; CAMK2A; PPP1CB; GRM1; MAP2K2
Neurotrophin signaling pathway
BAD; PSEN2; PDPK1; SHC1; MAPK3; YWHAE; Fasl; RHOA; MAPK8; TP73
Serotonergic synapse
PLCB1; PRKACB; BRAF; KRAS; PRKACA; PLCB3; CYP4X1; HTR3E; GNG3; GNAO1
Long-term depression
PLA2G4D; LYN; NRAS; GRIA3; PRKCB; GNA13; ITPR3; CRH; GNAI1; PPP1R17
Regulation of actin cytoskeleton
HRASA; MYLK4; Itgam&Itgb2; PIK3CG; ACTN1; ARHGEF7A; INSB; RAF1B; FGFR2; GSNA
Insulin signaling pathway
CALM1A; PRKACG; PTPRF; EXOC7; PRKAR1B; HK1; GSK3AA; PPP1CB; SHC3; PIK3R1
Progesterone-mediated oocyte maturation
IGF1RB; MAD2L2; ARAF; FZR1; HSP90AA1.1; ANAPC1; MAD1L1; ANAPC4; MOS; ADCY1B
Alcoholism
GNAI3; HDAC11; GNG13; HIST1H4E; SHC3; MAOB; DDC; GNG12; H2AFV; HIST1H3F
Hepatitis C
NFKB1; PIK3CD; IFNAR2; IFNA2; PIK3R2; STAT1; PPP2R2B; CLDN5; IFNA4; PPP2R1A
Pathways in cancer
TRAF2; SFPI1; PPARD; ARHGEF12; PDGFRA; APC; FGF9; WNT11; TPM3; MMP1
Proteoglycans in cancer
CAMK2B; CCND1; ANK2; FZD1; HPSE; ELK1; TIMP3; ITPR3; Casp3; HCLS1
Colorectal cancer
SMAD3; SMAD4; MAPK9; AXIN2; RAF1; MSH2; MAPK8; FOS; ARAF; PIK3R3
Renal cell carcinoma
PIK3CG; FH1; EGLN1; CDC42; PIK3R5; TGFA; TCEB1; PDGFB; PIK3CD; NRAS
Pancreatic cancer
MAPK8; MAPK3; TP53; AKT2; SMAD4; PIK3CA; CCND1; ARAF; TGFB2; RAF1
Endometrial cancer
MAPK3; SOS1; PIK3R5; PIK3CD; BRAF; KRAS; ELK1; MAP2K2; AXIN2; TRP53
Glioma
RB1; PIK3R3; SHC3; CAMK2G; NRAS; CALM3; PLCG1; BRAF; CAMK2D; PIK3CB
Prostate cancer
RAF1; INS; TCF7; PIK3CG; MTOR; MAPK3; CREB5; INS2; NKX3; INSRR
Thyroid cancer
KRAS; NTRK1; PAX8; RET; HRAS; MAP2K1; LEF1; TCF7L2; TFG; CCND1
Melanoma
MAP2K1; FGF19; PIK3CB; FGF22; TP53; RB1; FGF8; IGF1R; FGF5; MITF
Bladder cancer
HRAS; MAPK1; IL-8; EGF; DAPK1; TP53; KRAS; BRAF; RASSF1; E2F3
Chronic myeloid leukemia
RAF1; BAD; RUNX1; BRAF; CTBP2; MECOM; PIK3CG; CBLB; TGFB3; BCR
Acute myeloid leukemia
NFKB1; PPARD; MAPK1; RUNX1T1; MYC; STAT5B; AKT3; MAPK3; SPI1; PIM2
Non-small cell lung cancer
PIK3CD; TRP53; RARB; RXRB; PIK3CB; RXRA; BRAF; ERBB2; AKT1; KRAS

Protein Function

BRAF has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PSMC2; CSNK2A2; MYLK2; P2RX6; NOD1; Abca2; UBE2D1B; STK25; C10orf2; PDK1
Function MAP kinase kinase kinase activity
Related Protein RAF1; KIAA1804; MAP3K12; MAP3K4; TAOK3; MOS; TAOK1; TAOK2; ALPK2; YSK4
Function calcium ion binding
Related Protein NRXN1; PCDHGB4; JAG2; CBL; PLSCR4; KCNIP1B; ACTN3; GCH1; PLCD1B; CELSR1
Function identical protein binding
Related Protein KRTAP10-5; BNIP3L; CDC42; MCIN; GRIK5; EED; MIEF1; AKT1; RAF1; FADD
Function mitogen-activated protein kinase kinase binding
Related Protein BRAF; RAF1; ACE; TRIB1; TRIB3; PIN1; ARRB1; IGBP1; TAOK2; TRIB2
Function protein binding
Related Protein TEX19.1; ADRB1; AGRN; KLHL38; UBASH3A; MT1F; PIANP; PQBP1; NRXN1; STX4A
Function protein heterodimerization activity
Related Protein SNX6; PDGFA; BOK; SNX2; PHC2B; CAPN2; BOKB; INHA; SMAD4; CUL3
Function protein kinase activity
Related Protein RNASEL; PRKCI; SRPK1; TRIO; RPS6KA3; EPHA1; NLK; OXSR1A; SGK2B; KITA
Function protein serine/threonine kinase activity
Related Protein MKNK2; cka1; MASTL; PRKCBA; RPS6KB2; RAF1B; AURKB; GRK1B; AAK1; TSSK3
Function NOT small GTPase binding
Related Protein RAF1; BRAF

Interacting Protein

BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
MAP2K1

BRAF Related Articles

Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).