braf
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  • Official Full Name
  • v-raf murine sarcoma viral oncogene homolog B1
  • Background
  • The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three
  • Synonyms
  • BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9
Cat.#:BRAF-253HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BRAF, GST-tagged, Active
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Cat.#:BRAF-174HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-175HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
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Cat.#:BRAF-176HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
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Cat.#:BRAF-177HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-178HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-179HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-180HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-181HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-182HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-183HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-22HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-26566THTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF
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Cat.#:BRAF-26567THTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF
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Cat.#:BRAF-319HTag:GST/His
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-His-tagged
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Cat.#:BRAF-320HTag:GST
Source (Host):Sf21 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
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Cat.#:BRAF-321HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
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Cat.#:BRAF-550HTag:N-terminal His-tag (BRAF), N-terminal FLAG-tag (p50)
Source (Host):Insects cellSpecies:Human
Product nameRecombinant Human BRAF/p50 Protein, Flag-His-tagged
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Cat.#:BRAF-791HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BRAF protein, GST-tagged
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Cat.#:BRAF-2477MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BRAF Protein
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Cat.#:BRAF-6854CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BRAF
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Cat.#:BRAF-11759ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BRAF
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Cat.#:BRAF-994HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Raf Murine Sarcoma Viral Oncogene Homolog B1, GST-tagged
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Cat.#:BRAF-8414HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF 293 Cell Lysate
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Involved Pathway

BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TNFRSF1A; FGF4; RAC3; PDGFB; NTRK2; FGF14; FGF1; PAK2A; PPM1NB; TAOK2
ErbB signaling pathway
ERBB3A; PAK2A; NCK2A; NRAS; PRKCBA; STAT5B; RPS6KB1B; PRKCG; PTK2AB; RAF1A
Rap signaling pathway
MAP2K6; ANGPT1; CALM4; SIPA1L1; GNAI3; FGF21; PLCB2; FGF20; PIK3R3; FGF2
cAMP signaling pathway
RAC1; RAP1B; ATP1A4; GRIN2C; EP300; PPP1CA; GLP1R; ATP1B4; SLC9A1; PPARA
Chemokine signaling pathway
GM1987; BRAF; CCL21; IKBKG; CXCL1; XCL1; CCL28; NFKBIA; GNB2; CCL24
FoxO signaling pathway
SETD7; PIK3R3B; IRS4; AGAP2; HOMER2; GADD45B; TGFBR1; CCNB3; INSR; TGFB1
mTOR signaling pathway
PIK3R5; MTOR; PTEN; ULK1; AKT1S1; ULK2; PRKCA; RRAGCA; TSC2; MAPK1
Vascular smooth muscle contraction
GUCY1A3; PRKCDA; PRKCHA; ADCY1A; PLA2G3; PLA2G4D; RHOAD; MYL6; PLCB2; PPP1R14AB
Focal adhesion
CDC42; FLT1; PTEN; MYL5; TNK1; PAK6; VASPA; PAK2A; CHAD; COL4A1
Natural killer cell mediated cytotoxicity
IFNA16; ULBP2; PLCG2; VAV3; SH3BP2; PIK3CD; KIR2DS5; PIK3R3; HLA-G; MAPK3
Long-term potentiation
GRM1; PLCB3; PRKACB; PLCB2; HRAS; GRIA1; MAPK1; PPP3CC; PRKCB; CALML3
Neurotrophin signaling pathway
RPS6KA5; MAPKAPK2; MAP2K2; ATF4; PTPN11; RPS6KA3; RELA; BAX; SH2B1; IRAK4
Serotonergic synapse
HRAS; BRAF; CYP2C70; HTR3A; TRPC1; ALOX15; GNGT2; HTR2C; HTR4; CYP2C37
Long-term depression
GRIA2; MAP2K1; BRAF; MAPK3; PLCB1; GRIA3; ITPR3; GNA12; GNAI2; GRID2
Regulation of actin cytoskeleton
WASLA; INSB; ITGB6; HRASB; BAIAP2A; PAK2; PPP1CC; GSN; PIP4K2B; PDGFC
Insulin signaling pathway
RAF1A; RAF1B; PPP1CA; PRKAG2; RPTOR; PRKACA; MAP2K1; PPP1R3DA; SLC2A4; GRB2B
Progesterone-mediated oocyte maturation
PIK3CB; MAPK3; IGF1R; RAF1A; PIK3R5; HSP90AB1; PIK3R2; RAF1; PRKACBA; BUB1
Alcoholism
GNAI3; H2BFWT; HIST2H3C2; HIST1H3F; HDAC2; CALM1; CALM4; HIST1H3C; HDAC3; H2AFB1
Hepatitis C
IFNA2; PPP2R1A; EIF2AK3; IFNA14; TNFRSF1A; NRAS; PIK3CA; RXRA; GSK3B; OCLN
Pathways in cancer
Ar; FGF22; IGF1R; TGFB3; LPAR5; WNT6; AGTR1B; IKBKG; HRAS; TP53
Proteoglycans in cancer
WNT2; CAMK2G; SDC1; CBLB; PRKCB; DROSHA; CBL; HRAS; Fasl; NRAS
Colorectal cancer
RAC2; KRAS; AKT1; MAPK1; AKT2; APC; MLH1; TGFB2; ARAF; RAC1
Renal cell carcinoma
EP300; HRAS; PIK3R1; RAF1; PIK3R2; EPAS1; PAK1; PIK3CG; FH1; ARAF
Pancreatic cancer
MAP2K1; PIK3R1; VEGFA; TGFB3; SMAD3; PIK3CA; ARHGEF6; PIK3R2; RAD51; ARAF
Endometrial cancer
PIK3R5; ELK1; MLH1; BRAF; TCF7; ARAF; GSK3B; TP53; AKT2; MAP2K1
Glioma
PIK3R5; CCND1; SHC4; PLCG1; CAMK2D; SOS1; PDGFA; TP53; ARAF; PDGFRA
Prostate cancer
CREB5; TCF7L2; TCF7; NDRG1; CREB3L3; PDGFC; GSTP1; PIK3CG; FGFR2; SMARCA4
Thyroid cancer
NTRK1; MAP2K1; RXRG; MAP2K2; CDH1; MAPK3; RET; NRAS; TCF7L2; RXRB
Melanoma
PDGFRA; FGFR1; FGF21; PIK3CA; FGF6; MAP2K1; FGF4; ARAF; FGF13; TRP53
Bladder cancer
MMP1A; TYMP; E2F3; CCND1; RAF1; THBS1; RASSF1; UPK3A; E2F1; DAPK2
Chronic myeloid leukemia
TGFB3; HRAS; STAT5B; AKT2; BRAF; GAB2; MAP2K2; PIK3CD; CTBP2; PTPN11
Acute myeloid leukemia
CEBPA; STAT5A; NFKB1; EIF4EBP1; RUNX1T1; RARA; PIK3CG; CCNA1; MAPK1; ZBTB16
Non-small cell lung cancer
RXRB; RAF1; MAP2K1; RASSF1; NRAS; AKT1; PRKCA; BAD; AKT2; PIK3CA

Protein Function

BRAF has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein LARS; ATP2A1; ATP9A; CMPK1; LMTK2; EPHB4; FGFR1; KDR; CAMKK1B; PIK3C2A
Function MAP kinase kinase kinase activity
Related Protein MAP3K4; MOS; YSK4; MAP3K12; MAP3K15; MAP3K13; ALPK2; MAP3K14; KIAA1804; MAP3K5
Function calcium ion binding
Related Protein SLC24A2; CRP; SULF2A; OVAL; Npnt; CDH24; MYL7; FKBP9; CHP2; CETN3
Function identical protein binding
Related Protein PYDC3; C1QTNF9; DYNLT1B; ERBB3; ERN1; NQO1; APOE; SERPINA1D; ATG101; ADIPOR2
Function mitogen-activated protein kinase kinase binding
Related Protein TRIB2; TAOK2; BRAF; ACE; IGBP1; KSR1; RAF1; PIN1; MAPK8IP3; TRIB3
Function protein binding
Related Protein CYFIP1; CABP1; TOMM34; SNX20; ZNF511; CERS2; SFRP4; MARK2; CDC26; KIF20A
Function protein heterodimerization activity
Related Protein DMRT1; AOC3; ERBB2; H3F3A; MAFG; DMBX1; SDCBP2; DDIT3; GUCY1A3; SOX14
Function protein kinase activity
Related Protein EPHA2A; PKN2; BMPR1AB; NEK5; MAP2K1; CDKL2; ABL2; RIPK3; GRK1A; PRKD2
Function protein serine/threonine kinase activity
Related Protein STK35; PHKG1A; CSNK2A1; CSNK1G2B; BMPR1AB; CHEK1; RPS6KA2; SRPK1A; CASK; MAP4K4
Function NOT small GTPase binding
Related Protein BRAF; RAF1

Interacting Protein

BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
MAP2K1

BRAF Related Articles

Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).