braf
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  • Official Full Name
  • v-raf murine sarcoma viral oncogene homolog B1
  • Background
  • The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three
  • Synonyms
  • BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9
Cat.#:BRAF-253HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BRAF, GST-tagged, Active
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Cat.#:BRAF-174HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-175HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
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Cat.#:BRAF-176HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
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Cat.#:BRAF-177HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-178HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-179HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-180HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-181HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-182HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-183HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-22HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-26566THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human BRAF
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Cat.#:BRAF-26567THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human BRAF
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Cat.#:BRAF-319HTag:GST|His
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-His-tagged
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Cat.#:BRAF-320HTag:GST
Source (Host):Sf21 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
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Cat.#:BRAF-321HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
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Cat.#:BRAF-550HTag:His|Flag
Source (Host):Insects cellSpecies:Human
Product nameRecombinant Human BRAF/p50 Protein, Flag-His-tagged
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Cat.#:BRAF-791HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BRAF protein, GST-tagged
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Cat.#:BRAF-2477MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BRAF Protein
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Cat.#:BRAF-6854CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BRAF
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Cat.#:BRAF-11759ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BRAF
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Cat.#:BRAF-994HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Raf Murine Sarcoma Viral Oncogene Homolog B1, GST-tagged
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Cat.#:BRAF-8414HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human BRAF 293 Cell Lysate
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Involved Pathway

BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
NTRK2B; ZAK; RPS6KA4; ELK4; PAK1; NLK1; MAPKAPK5; MAPK1; BDNF; CACNG1
ErbB signaling pathway
NCK2; ARAF; RAF1A; PAK2A; CAMK2D1; SHC2; CDKN1BA; PAK2B; HRAS; RAF1B
Rap signaling pathway
MAGI2; PLCB4; FPR1; SKAP1; ITGAL; MAPK3; MAP2K3; FGFR1; LAT; PIK3R5
cAMP signaling pathway
ATP1B3; PIK3R2; ATP2B4; MLLT4; CALM1; RAC1; PIK3CA; CREB3L2; GRIA4; CALML5
Chemokine signaling pathway
ELMO1; CXCR2; NFKBIB; CXCL2; CCL2; CRK; CXCR1; GNGT2; CCL4L2; JAK2
FoxO signaling pathway
FOXO6; USP7; TGFBR1; CCND1; IGF1R; AKT3A; TGFB3; GABARAPA; SGK2B; MAP2K1
mTOR signaling pathway
CAB39L1; DDIT4; RB1CC1; PTEN; MAPK3; HIF1A; PIK3CA; PIK3R5; AKT3A; PRR5
Vascular smooth muscle contraction
RHOAC; PRKG1; PPP1R14AA; GNA13A; PPP1R14A; ARHGEF11; KCNMB3; CALD1; CACNA1DA; PPP1CA
Focal adhesion
COL6A4; RAPGEF1B; PAK7; MAPK6; PARVA; PDPK1; ROCK2; SHC2; VCL; FLNA
Natural killer cell mediated cytotoxicity
FCGR3A; IFNG; IFNA16; KIR2DS2; TNF; HLA-A; MAPK1; ITGAL; RAET1E; PLCG1
Long-term potentiation
NRAS; PLCB2; PPP3CA; RAP1A; PRKCG; PRKACA; GRIN1; GRIN2D; GRIA1; GRIN2B
Neurotrophin signaling pathway
CAMK2G; MAGED1; CALML3; BDNF; CALML5; RPS6KA2; SH2B2; Fasl; MAPK1; SHC2
Serotonergic synapse
CYP4X1; HTR6; ALOX12E; GNAQ; GNG3; CYP2C39; PLCB2; BRAF; ALOX15; GABRB3
Long-term depression
GNAZ; BRAF; GNA12; RYR1; CRHR1; PLA2G4C; PLA2G4A; NOS1; IGF1R; PRKCG
Regulation of actin cytoskeleton
PIKFYVE; RAF1A; ITGB4; MSN; DIAPH1; PFN3; ITGA8; NRAS; PIP5K1B; RHOAD
Insulin signaling pathway
PKLR; FOXO1; GRB2; PRKAB1A; CBL; MKNK2; MAP2K2; INSR; PYGB; MKNK2A
Progesterone-mediated oocyte maturation
RPS6KA3; PRKACBB; MOS; RPS6KA2; MAD1L1; RAF1A; INSB; Adcy4; RPS6KA1; CDK1
Alcoholism
GNB1; HDAC9; HIST1H2BO; HDAC5; GRB2; HIST1H2AD; HDAC2; HIST1H2AO; HIST1H4G; HDAC7
Hepatitis C
TRAF6; IFNA21; CLDN16; MAPK11; STAT1; IFNA13; IFNA10; EIF2AK1; MAPK9; IRF1
Pathways in cancer
WNT2B; HRAS; RAC2; GNG4; MAP2K2; GNG2; BID; FGF16; IGF1R; TGFB2
Proteoglycans in cancer
MAPK11; WNT8A; CAV1; LUM; CCND1; GPC3; DROSHA; RPS6KB1; NANOG; PTCH1
Colorectal cancer
DCC; TGFBR2; SMAD3; TP53; RAC1; RAC2; RHOA; AXIN2; MSH6; FOS
Renal cell carcinoma
MAPK1; PAK6; FH; GAB1; SLC2A1; ARNT2; HIF1A; TGFB1; TGFB2; AKT2
Pancreatic cancer
AKT1; PIK3CG; RELA; TGFB2; RAC2; RALB; PIK3R1; RALGDS; RAF1; MAPK9
Endometrial cancer
CTNNA3; ARAF; CASP9; MAP2K1; ERBB2; LEF1; TP53; PDPK1; PIK3R1; HRAS
Glioma
PIK3R5; PIK3CB; PIK3CD; IGF1R; CAMK2B; PIK3CG; PLCG1; CALM1; IGF1; PDGFRB
Prostate cancer
TCF7L2; MAPK1; FGFR2; NKX3-1; CCNE2; EP300; IGF1R; FOXA1; MTOR; FOXO1
Thyroid cancer
RET; HRAS; CCDC6; KRAS; LEF1; RXRB; TPR; CDH1; MAP2K2; TRP53
Melanoma
FGF5; PDGFRB; CCND1; HGF; FGF10; RB1; Pdgfa&Pdgfb; PDGFC; PIK3R5; IGF1
Bladder cancer
MMP2; RPS6KA5; E2F1; HBEGF; MMP1; MMP9; RAF1; VEGFA; MAPK3; KRAS
Chronic myeloid leukemia
SHC1; MDM2; TGFB1; PIK3R1; RUNX1; NFKB1; ABL1; CCND1; SOS1; RB1
Acute myeloid leukemia
EIF4EBP1; MAP2K2; GRB2; MYC; SPI1; AKT2; MAPK3; CCND1; PIK3R3; PIM1
Non-small cell lung cancer
RB1; TP53; ALK; PLCG1; CCND1; MAPK1; HRAS; FOXO3; PIK3CA; BAD

Protein Function

BRAF has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PGK2; RUNX3; HSPA13; EPHA4; VWA8; P2RX3A; WEE2; LTK; RTCB; PRKACA
Function MAP kinase kinase kinase activity
Related Protein MAP3K1; RAF1; MAP3K4; MAP3K8; MAP3K6; TAOK3; ZAK; MAP3K3; MAP3K13; EGFR
Function calcium ion binding
Related Protein FAT1A; CDH8; ITSN2A; PCDHA9; PPEF1; SYT17; THBS4B; PVALB4; aLA; CABP7
Function identical protein binding
Related Protein CLDN20; POLG2; C; DRD4; CCL4; ALDOA; CAV1; AIRE; ASMT; HTT
Function mitogen-activated protein kinase kinase binding
Related Protein TRIB3; PIN1; KSR1; RAF1; IGBP1; TAOK2; TRIB2; DLG1; MAPK8IP3; TRIB1
Function protein binding
Related Protein DSTN; GGPS1; PNRC2; QARS; MAP3K2; LILRB3; RCAN3; HSPA4; MGAT5B; JIP1
Function protein heterodimerization activity
Related Protein PRMT5; HNF1A; FLOT2; ADRA2A; ADRB1; NOTCH1; TLR6; H2AFB1; DMRTA2; KCNK9
Function protein kinase activity
Related Protein BMPR1BA; RPS6KB2; NLK2; DCLK1A; CCND1; MAP2K5; MAPK14B; INSRA; PLK5; NRBP2
Function protein serine/threonine kinase activity
Related Protein STK17A; RIPK3; PRKD1; NEK2; cka1; GRK1A; ADCK5; ROCK2B; TTK; RPS6KA2
Function NOT small GTPase binding
Related Protein RAF1; BRAF

Interacting Protein

BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
MAP2K1

BRAF Related Articles

Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).