braf
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  • Official Full Name
  • v-raf murine sarcoma viral oncogene homolog B1
  • Background
  • The Raf proteins are a family of serine/threonine-specific kinases that serve as a central intermediate in transmitting extracellular signals to the mitogen-activated protein kinase cascade, which controls cell growth, differentiation and survival. Three
  • Synonyms
  • BRAF; v-raf murine sarcoma viral oncogene homolog B1; serine/threonine-protein kinase B-raf; BRAF1; p94; 94 kDa B-raf protein; proto-oncogene B-Raf; murine sarcoma viral (v-raf) oncogene homolog B1; B-Raf proto-oncogene serine/threonine-protein kinase (p9
Cat.#:BRAF-253HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human BRAF, GST-tagged, Active
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Cat.#:BRAF-174HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-175HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
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Cat.#:BRAF-176HTag:DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, DDK-tagged
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Cat.#:BRAF-177HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-178HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-179HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-180HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-181HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-182HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-183HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-22HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human BRAF protein, MYC/DDK-tagged
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Cat.#:BRAF-26566THTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF
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Cat.#:BRAF-26567THTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF
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Cat.#:BRAF-319HTag:GST/His
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-His-tagged
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Cat.#:BRAF-320HTag:GST
Source (Host):Sf21 cellsSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
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Cat.#:BRAF-321HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human BRAF Protein, GST-tagged
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Cat.#:BRAF-550HTag:N-terminal His-tag (BRAF), N-terminal FLAG-tag (p50)
Source (Host):Insects cellSpecies:Human
Product nameRecombinant Human BRAF/p50 Protein, Flag-His-tagged
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Cat.#:BRAF-791HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human BRAF protein, GST-tagged
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Cat.#:BRAF-2477MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse BRAF Protein
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Cat.#:BRAF-6854CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken BRAF
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Cat.#:BRAF-11759ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish BRAF
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Cat.#:BRAF-994HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human V-Raf Murine Sarcoma Viral Oncogene Homolog B1, GST-tagged
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Cat.#:BRAF-8414HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human BRAF 293 Cell Lysate
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Involved Pathway

BRAF involved in several pathways and played different roles in them. We selected most pathways BRAF participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF3; RRAS; PPM1AA; RPS6KA5; NTRK2B; PAK2; GNG12; RPS6KA3A; FGF13; CACNG7A
ErbB signaling pathway
CAMK2G; MAPK8A; ARAF; ERBB4; ABL1; CAMK2D2; MAPK1; PTK2; BAD; MAP2K4A
Rap signaling pathway
PRKCI; CALML5; FGF19; PRKD2; RAF1; KRAS; Adcy4; GNAI1; MLLT4; FGF4
cAMP signaling pathway
HTR1E; GRIN2A; ROCK2; GHSR; CALM2; RYR2; PDE3A; FOS; HCN2; VIPR2
Chemokine signaling pathway
NFKB1; GNAI3; GNAI1; CCL11; PIK3R1; CCL23; PF4V1; IKBKG; GRK6; CCL28
FoxO signaling pathway
GRB2; FOXG1A; SGK2A; PTENB; GRB2B; TNFSF10; GRM1; PRKAG2; HRASB; G6PC2
mTOR signaling pathway
IKBKB; INSB; RPS6KAL; HIF1A; HIF1AB; TSC1; PIK3R5; POLDIP3; IRS1; PTEN
Vascular smooth muscle contraction
KCNMA1A; CACNA1SA; PPP1R14AA; MAP2K1; EDNRAA; GNA15.1; ACTG2; GNA15.4; NPR1; ADRA1BB
Focal adhesion
LAMA3; IBSP; MAPK9; CCND2A; FYN; PRKCA; VTN; COMP; MAP2K1; COL6A1
Natural killer cell mediated cytotoxicity
VAV1; KLRC2; KLRC4-KLRK1; MICB; BRAF; NCR1; CD247; NFATC1; HLA-B; NCR3
Long-term potentiation
PPP3CA; PLCB4; CALM1; PPP3CB; CALML5; CAMK2D; GRIN2A; ATF4; PPP1R1A; GRM1
Neurotrophin signaling pathway
TP73; PIK3R2; HRAS; SORT1; SHC4; BDNF; PSEN2; ARHGDIB; IKBKB; IRAK2
Serotonergic synapse
PLA2G4D; GNAO1; PRKACG; HTR2C; GNB2; MAOB; GNGT2; HTR3A; GNAI3; PLCB1
Long-term depression
ITPR3; PLA2G4D; GNA11; IGF1; GNAI2; GNAI1; CRHR1; PRKCG; GNAO1; PPP1R17
Regulation of actin cytoskeleton
RAC1B; FGF9; PIKFYVE; PPP1R12A; PAK6B; MAPK1; MSNA; ITGB4; FGF1; PIP5KL1
Insulin signaling pathway
RHEB; NRAS; PIK3R1; PPP1CAB; EXOC7; MKNK2; SREBF1; PYGL; CALML3; RPS6KB1
Progesterone-mediated oocyte maturation
CDC25B; MAPK8A; PIK3CD; PPP1R2P9; PIK3R3B; MAPK10; PGR; AKT2L; ANAPC5; PRKACBB
Alcoholism
GNAI3; HIST1H2AI; DRD2; CALML5; GNB4; HDAC3; SHC3; HIST1H2BK; HIST1H2BN; CREB3
Hepatitis C
IFNA16; IFNA2; STAT3; IKBKE; TRP53; IRF9; IFNA13; IFNAR2; IFNA8; CLDN15
Pathways in cancer
PLCB3; FH1; WNT3A; RELA; MAP2K1; WNT16; GLI2; Casp3; FGF19; WNT7A
Proteoglycans in cancer
WNT16; ITGB3; FGFR1; TGFB2; FZD9; PIK3R3; RDX; PLCE1; NANOG; TFAP4
Colorectal cancer
CASP9; PIK3R3; TGFB3; SMAD2; APC2; RAC2; AKT2; BAX; LEF1; APPL1
Renal cell carcinoma
CUL2; AKT1; PAK3; EPAS1; MAP2K2; MAP2K1; RBX1; PTPN11; RAP1B; PIK3CB
Pancreatic cancer
MAPK1; ERBB2; PIK3CG; BCL2L1; CCND1; SMAD4; BAD; IKBKB; MAPK8; CASP9
Endometrial cancer
KRAS; AKT2; AKT1; AXIN2; SOS1; PIK3CD; TCF7; AXIN1; BRAF; APC
Glioma
MAP2K2; NRAS; PIK3CB; SHC2; MDM2; RAF1; PRKCB; IGF1R; RB1; PDGFRB
Prostate cancer
SRD5A2; AKT2; PDGFRA; CREB3L1; ERBB2; RB1; CREB3L3; HSP90AA1; PIK3R3; ARID1A
Thyroid cancer
MAP2K1; TPM3; MAPK3; NCOA4; TCF7L2; TFG; MAP2K2; RXRG; PAX8; CCDC6
Melanoma
PIK3R2; FGF22; CCND1; FGF11; RB1; PIK3R3; FGF2; FGFR1; PDGFRA; TP53
Bladder cancer
SRC; MMP9; MAPK1; RASSF1; NRAS; DAPK1; BRAF; HRAS; CCND1; EGF
Chronic myeloid leukemia
SMAD3; CCND1; TRP53; ABL1; NFKBIA; PIK3CD; PIK3R2; ARAF; PIK3R3; IKBKG
Acute myeloid leukemia
AKT3; AKT2; PIK3R2; PIK3R1; RUNX1; SPI1; CHUK; MAPK3; PIK3CG; IKBKB
Non-small cell lung cancer
PRKCA; KRAS; TGFA; NRAS; HRAS; PIK3CA; PLCG2; PRKCG; PIK3R1; AKT1

Protein Function

BRAF has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAF itself. We selected most functions BRAF had, and list some proteins which have the same functions with BRAF. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATAD5B; C9orf96; NOLC1; PPIP5K2; INSRR; ASNA1; ABCC3; JAK3; KIF14; HSPA5
Function MAP kinase kinase kinase activity
Related Protein MAP3K3; MAP3K5; TAOK1; KIAA1804; MAP3K8; TAOK2; MAP3K14; MAP3K1; TAOK3; EGFR
Function calcium ion binding
Related Protein SPOCK1; LALBA; EMR2; SMOC1; DHH; PLA2G10; CD248A; MYL9A; HEG; NKD1
Function identical protein binding
Related Protein DRG1; BAX; MCM10; IGF2R; NUP153; DIAPH1; RB1; CLDN11; Serpina1b; PPPDE2
Function mitogen-activated protein kinase kinase binding
Related Protein RAF1; PIN1; ACE; BRAF; KSR1; TRIB1; MAPK8IP3; ARRB1; TRIB3; TAOK2
Function protein binding
Related Protein OAS3; CC10; SELP; PKM2; SDHA; TLE2; GZMM; XRCC4; PRPF31; PSMB2
Function protein heterodimerization activity
Related Protein ADIPOR1; HIST1H2AM; UGT1A6A; EXT2; GABPB1; HIST1H2AI; TFAP2B; PHC2B; Fzd4; WHRN
Function protein kinase activity
Related Protein GUCY2F; CSNK1E; DYRK3; MAPK12A; RIPK4; EPHA4B; SCYL2; KITA; RPS6KB2; PKN2
Function protein serine/threonine kinase activity
Related Protein PKMYT1; GSK3B; WNK1; TSSK4; ACVR2B; PINK1; EIF2AK4; MTOR; STK38; TBK1
Function NOT small GTPase binding
Related Protein RAF1; BRAF

Interacting Protein

BRAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAF here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAF.
MAP2K1

BRAF Related Articles

Johnson, DB; Peng, CW; et al. Nivolumab in melanoma: latest evidence and clinical potential. THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 7:97-106(2015).
Bellizzi, AM; et al. Screening for Lynch Syndrome: A No-Brainer BRAF V600E Mutation-Specific Immunohistochemistry: Caveat Emptor. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:320-324(2015).