CARD11
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Official Full Name
caspase recruitment domain family, member 11 -
Overview
CARD11/Carma1/Bimp3 belongs to the MAGUK (membrane-associated guanylate kinase) family that typically function as molecular scaffolds in the assembly of multiprotein complexes. MAGUK family members contain an SH3 domain, a PDZ domain and a GuK domain homo -
Synonyms
CARD11;caspase recruitment domain family, member 11;caspase recruitment domain-containing protein 11;bcl10 interacting maguk protein 3;BIMP3;card maguk protein 1;CARMA1;carma 1;card-maguk protein 1;CARD-containing MAGUK protein 1;bcl10-interacti
Recombinant Proteins
- Mouse
- Human
- Chicken
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- E. coli
- DDK
- Myc
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
CARD11 involved in several pathways and played different roles in them. We selected most pathways CARD11 participated on our site, such as NF-kappa B signaling pathway,T cell receptor signaling pathway,B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| T cell receptor signaling pathway | MAPK9,PPP3CB,PIK3R3,GRB2,PPP3CC,EVLB,FYN,PDPK1,IL5,NRAS |
| B Cell Receptor Signaling Pathway | VAV3,NFATC2,CRK,CD22,PIK3R1,RASGRP3,PTPN6,SOS1,IKBKG,PLEKHA2 |
| NF-kappa B signaling pathway | DDX58,BIRC2,BCL2A1,PLCG1,TAB2,LTB,NFKBIA,CCL21B,LY96,MAP3K7 |
Protein Function
CARD11 has several biochemical functions, for example, CARD domain binding,guanylate kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD11 itself. We selected most functions CARD11 had, and list some proteins which have the same functions with CARD11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CARD domain binding | CARD9,CARD14,RIPK2,MAVS,NOD1,C9orf89 |
| guanylate kinase activity | DLG4,DLG3,DLG1,DLG1L,GUK1A,GUK1B,TJP2,GUK1,CASK,DLG4B |
| protein binding | COPS4,PLIN1,PPP3CB,IRS1,CARD8,PQBP1,CDKN3,PTTG1,LITAF,CBX6 |
Interacting Protein
CARD11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD11.
BCL10;COPS5;AKT1;MALT1;IKBKG;PDPK1;BCRF1;TAB1;GPS1
Resources
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References
- Chinen, J; Notarangelo, LD; et al. Advances in basic and clinical immunology in 2013. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 133:967-976(2014).
- Wang, H; Zhao, J; et al. CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 176:238-245(2014).
