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CARD11

Official Full Name

caspase recruitment domain family, member 11
Overview

CARD11/Carma1/Bimp3 belongs to the MAGUK (membrane-associated guanylate kinase) family that typically function as molecular scaffolds in the assembly of multiprotein complexes. MAGUK family members contain an SH3 domain, a PDZ domain and a GuK domain homo
Synonyms

CARD11; caspase recruitment domain family, member 11; caspase recruitment domain-containing protein 11; bcl10 interacting maguk protein 3; BIMP3; card maguk protein 1; CARMA1; carma 1; card-maguk protein 1; CARD-containing MAGUK protein 1; bcl10-interacti;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CARD11-0391H	Recombinant Human CARD11 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CARD11-10718H	Recombinant Human CARD11, His-tagged	E.coli	His	C-term-350a.a.	$319 / 25ug
Human	CARD11-7850HCL	Recombinant Human CARD11 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CARD11-6717H	Recombinant Human CARD11 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CARD11-301642H	Recombinant Human CARD11 protein, GST-tagged	E.coli	GST	Arg228-Lys481	Inquiry
Human	CARD11-01H	Recombinant Human CARD11 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Card11-385M	Recombinant Mouse Card11 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		$998 / 20ug $2,998 / 100ug
Mouse	CARD11-2728M	Recombinant Mouse CARD11 Protein	Mammalian Cell	His		Inquiry
Mouse	CARD11-1229M	Recombinant Mouse CARD11 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	CARD11-1229M-B	Recombinant Mouse CARD11 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	CARD11-1312C	Recombinant Chicken CARD11	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CARD11 Related Articles
CARD11 Related Research Area

CARD11 involved in several pathways and played different roles in them. We selected most pathways CARD11 participated on our site, such as NF-kappa B signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
NF-kappa B signaling pathway	Ccl21c;TNFRSF13C;MAP3K14;PIAS4;CARD11;TNFAIP3;TRIM25;GADD45B;CCL19
T cell receptor signaling pathway	CD3D;IKBKG;CD247;RHOA;ZAP70;PPP3CB;NFKB1;VAV1;CBLC
B cell receptor signaling pathway	PDPK1A;BCL2L11;CMTM3;PILRB;MAP2K1;PPP3CA;PIK3R5;NFATC3;CRK

CARD11 has several biochemical functions, for example, CARD domain binding, guanylate kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD11 itself. We selected most functions CARD11 had, and list some proteins which have the same functions with CARD11. You can find most of the proteins on our site.

Function	Related Protein
CARD domain binding	MAVS;NOD1;C9orf89;CARD9;CARD14;RIPK2;CARD11
guanylate kinase activity	DLG1;MPP1;DLG3;MPP3;DLG4;CASK;CARD11;TJP2;DLG4B
protein binding	GPA33;MMP9;SUDS3;TACR3;ALDH3A1;PLGRKT;DUSP7;ISG15;TMEM8A

CARD11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD11 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD11.

BCL10; COPS5; AKT1; MALT1; IKBKG; PDPK1; BCRF1; TAB1; GPS1

Wang, H; Zhao, J; et al. CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 176:238-245(2014).

Chinen, J; Notarangelo, LD; et al. Advances in basic and clinical immunology in 2013. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 133:967-976(2014).

Regulator of NFkB