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CARD16

Official Full Name

caspase recruitment domain family, member 16
Overview

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Synonyms

CARD16; caspase recruitment domain family, member 16; caspase recruitment domain-containing protein 16; COP; COP1; PSEUDO ICE; PSEUDO-ICE; CARD only domain-containing protein 1; CARD only protein; Caspase-1 dominant-negative inhibitor pseudo-ICE; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme; Pseudo interleukin-1beta converting enzyme; OTTHUMP00000232049; OTTHUMP00000232050; c;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CARD16-1690H	Recombinant Human CARD16 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CARD16-7848HCL	Recombinant Human CARD16 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CARD16-7849HCL	Recombinant Human CARD16 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CARD16-6035H	Recombinant Human CARD16 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CARD16-2523H	Recombinant Human CARD16 Protein, His-tagged	E.coli	His		Inquiry
Human	CARD16-1950HF	Recombinant Full Length Human CARD16 Protein, GST-tagged	In Vitro Cell Free System	GST	97 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CARD16 Related Articles
CARD16 Related Research Area

CARD16 involved in several pathways and played different roles in them. We selected most pathways CARD16 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CARD16 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD16 itself. We selected most functions CARD16 had, and list some proteins which have the same functions with CARD16. You can find most of the proteins on our site.

Function	Related Protein
cysteine-type endopeptidase inhibitor activity	CST11;STFA2;AHSG1;CST6;CSTA;CST7;HRG;BIRC7;AHSG

CARD16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD16 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD16.

TRIB2

Cui, J; Chen, YJ; et al. Mechanisms and pathways of innate immune activation and regulation in health and cancer. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3270-3285(2014).

Voruganti, VS; Laston, S; et al. Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children. CYTOKINE 60:634-638(2012).

Inflammasome