casp2
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  • Official Full Name
  • caspase 2, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • Apoptosis related cysteine peptidase; CASP 2; Casp 2L Pro; CASP2; Caspase 2 apoptosis related cysteine protease; Caspase2; Developmentally down regulated 2; ICH 1; ICH 1 protease; ICH 1L; ICH 1L/1S; ICH1; ICH1 protease; ICH1L/1S; NEDD 2; NEDD2 apoptosis regulatory gene; Neural precursor cell expressed; Neural precursor cell expressed developmentally down regulated 2; OTTHUMP00000025259; OTTHUMP00000202227; neural precursor cell expressed developmentally down-regulated protein 2; EC 3.4.22.55; Protease ICH-1
Cat.#:CASP2-0419HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP2 Protein, GST-Tagged
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Cat.#:CASP2-10731HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP2, GST-tagged
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Cat.#:CASP2-195HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP2, His-tagged
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Cat.#:CASP2-296HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP2 Protein, His/GST-tagged
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Cat.#:CASP2-484HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP2
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Cat.#:CASP2-819HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP2 Protein, His-tagged
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Cat.#:CASP2-2751MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CASP2 Protein
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Cat.#:Casp2-297MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Casp2 Protein, His-tagged
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Cat.#:CASP2-1144RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CASP2 Protein
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Cat.#:CASP2-4013CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CASP2
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Cat.#:CASP2-3823ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CASP2
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Cat.#:CASP2-747HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 2, Apoptosis-related Cysteine Peptidase
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Cat.#:CASP2-285HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP2 cell lysate
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Involved Pathway

CASP2 involved in several pathways and played different roles in them. We selected most pathways CASP2 participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Apoptosis Modulation by HSP70, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
CDKN2A; CASP6; PPP3CC; BAD; CASP12; CYCS; PIK3R3B; CASP7; CASP8L1; DCC
Apoptosis Modulation and Signaling
BIK; SEPT4; BAG3; HN1; CDKN2A; DAXX; HRK; DIABLO; BOK; BLK
Apoptosis Modulation by HSP70
DERL3; CASP2
Caspase cascade in apoptosis
SATB1; DFFA; ACTA1; CFL2; NUMA1; GAS2; CASP4; TFAP2A; PARP1; CRADD
Cell death signalling via NRAGE, NRIF and NADE
BCL2L11; ARHGEF17; OBSCN; MCF2L; TRIO; ARHGAP4A; ITSN1; ARHGEF9; CASP2; ARHGEF3
HIV-1 Nef: Negative effector of Fas and TNF-alpha
CRADD; DFFA; DAXX; CASP2
Immune System
B2ML; RAP1GAP2; CRP; MYO9B; TIRAP; TREML2; TRIM6; RNF41; CYBB; ASB3
Innate Immune System
CD300E; BTR22; S100B; C1rb; TNIP2; SIGLEC15; WASF3; DEFB1; IRF2; DDX41

Protein Function

CASP2 has several biochemical functions, for example, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic signaling pathway, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP2 itself. We selected most functions CASP2 had, and list some proteins which have the same functions with CASP2. You can find most of the proteins on our site.
Function
Related Protein
Function cysteine-type endopeptidase activity
Related Protein USP43; USP17L2; PSD; CTSBA; USP4; USP10; USP18; CTSSB.1; USP22; CTSSB.2
Function cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Related Protein CASP2; CFLAR; CASP8; CASP9; CASP14; CFLARA; CASP8L1; CASP10
Function enzyme binding
Related Protein HIST1H2AN; Txn1; PHB; U2AF2; ATP2A2; VAPB; SELS; HNRNPUL1; GSTM2; GBP1
Function protein binding
Related Protein FIS1; NOS1AP; CRTC1; ZNF329; PCGF2; TRIP12; NFKBIB; TAF1A; MCM10; ZBTB25
Function protein domain specific binding
Related Protein DYNLL1; CTBP1; STX18; ARHGEF4; ETV6; ATP1A1; NEFL; STX1B; ZFP521; GSN

Interacting Protein

CASP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP2.
CRADD; PIDD1; PRKDC

CASP2 Related Articles

Zhang, H; Sweezey, NB; et al. LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L391-L402(2015).
Wilson, CH; Shalini, S; et al. Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. CELL DEATH & DISEASE 6:-(2015).