casp5
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  • Official Full Name
  • caspase 5, apoptosis-related cysteine peptidase
  • Background
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
  • Synonyms
  • Apoptosis related cysteine protease; apoptosis-related cysteine protease; CASP5; ICE(rel)III; ICERELIII; ICH 3; ICH 3 protease; ICH3; TY; TY Protease; caspase-5; CASP-5; OTTHUMP00000045729; OTTHUMP00000209889; OTTHUMP00000231914; OTTHUMP00000231915; caspase 5, apoptosis-related cysteine peptidase; MGC141966; EC 3.4.22.58; EC 3.4.22
Cat.#:CASP5-1348HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human CASP5 Protein (137-327 aa), His-tagged
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Cat.#:CASP5-0425HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CASP5 Protein, GST-Tagged
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Cat.#:CASP5-10734HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP5, GST-tagged
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Cat.#:CASP5-32HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human Caspase-5 Enzyme
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Cat.#:CASP5-608HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CASP5
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Cat.#:CASP5-7647HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP5 protein, His & T7-tagged
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Cat.#:CASP5-821HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CASP5 Protein, His-tagged
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Cat.#:CASP5-600HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Caspase 5, Apoptosis-related Cysteine Peptidase
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Cat.#:CASP5-7835HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CASP5 293 Cell Lysate
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Involved Pathway

CASP5 involved in several pathways and played different roles in them. We selected most pathways CASP5 participated on our site, such as NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NOD-like receptor signaling pathway
SUGT1; IL1B; CASP8; MAPK13; IL-8; MAPK11; MAP3K7IP3; CARD8; CARD9; IL18

Protein Function

CASP5 has several biochemical functions, for example, NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASP5 itself. We selected most functions CASP5 had, and list some proteins which have the same functions with CASP5. You can find most of the proteins on our site.
Function
Related Protein
Function NOT cysteine-type endopeptidase activity involved in execution phase of apoptosis
Related Protein CASP12; CASP5; CASP1; CASPB; CASPBL; CASP4; PSD; CASPA
Function cysteine-type peptidase activity
Related Protein CTSJ; CAPN8; UFSP2; DESI2; ATG4B; CASPBL; GM12824; CASP6L2; FAM49BA; CAPN12

Interacting Protein

CASP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CASP5.
NLRP1