CBR1
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Official Full Name
carbonyl reductase 1
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Overview
Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. -
Synonyms
CBR1; carbonyl reductase 1; CBR; carbonyl reductase [NADPH] 1; SDR21C1; short chain dehydrogenase/reductase family 21C; member 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reducta;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
- Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
- Aspergillus niger (strain CBS 513.88 / FGSC A1513)
- Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
- Aspergillus terreus (strain NIH 2624 / FGSC A1156)
- Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
- Chicken
- Coccidioides immitis (strain RS) (Valley fever fungus)
- Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
- Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
- Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
- Human
- Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
- Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
- Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
- Mortierella alpina (Oleaginous fungus) (Mortierella renispora)
- Mouse
- Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
- Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
- Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
- Rat
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
- Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
- Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
- Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
- Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
- Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
- Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | CBR1-142H | Recombinant Human Carbonyl Reductase 1 | E.coli | N/A | ||
Human | CBR1-26326TH | Recombinant Human CBR1 protein | E.coli | N/A | ||
Human | CBR1-0467H | Recombinant Human CBR1 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CBR1-26327TH | Recombinant Human CBR1 | E.coli | N/A | 277 amino acids | |
Human | CBR1-143H | Recombinant Human CBR1, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | CBR1-288HCL | Recombinant Human CBR1 cell lysate | N/A | |||
Human | CBR1-591H | Recombinant Human CBR1 Protein, His-tagged | E.coli | His | Ser2~Trp277 | |
Human | CBR1-0874H | Recombinant Human CBR1 Protein (Met1-Trp277), N-His tagged | E.coli | N-His | Met1-Trp277 | |
Human | CBR1-5128HFL | Recombinant Full Length Human CBR1, Flag-tagged | Mamanlian cells | Flag | ||
Human | CBR1-2642H | Recombinant Human CBR1 protein, GST-tagged | E.coli | GST | 2-277aa | |
Human | CBR1-1351H | Recombinant Human CBR1 Protein (2-277 aa), His-tagged | Yeast | His | 2-277 aa | |
Human | CBR1-2773HF | Recombinant Full Length Human CBR1 Protein, GST-tagged | In Vitro Cell Free System | GST | 277 amino acids | |
Mouse | Cbr1-791M | Recombinant Mouse Cbr1 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | Cbr1-592M | Recombinant Mouse Cbr1 Protein, His-tagged | E.coli | His | Asn66~Asp271 | |
Rat | CBR1-1159R | Recombinant Rat CBR1 Protein | Mammalian Cell | His | ||
Rat | Cbr1-593R | Recombinant Rat Cbr1 Protein, His-tagged | E.coli | His | Ser2~Asp271 | |
Rat | CBR1-817R | Recombinant Rat CBR1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | CBR1-817R-B | Recombinant Rat CBR1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) | RFL7133AF | Recombinant Full Length Ajellomyces Capsulata Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-310) | |
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) | RFL3438AF | Recombinant Full Length Aspergillus Clavatus Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-309) | |
Aspergillus niger (strain CBS 513.88 / FGSC A1513) | RFL1483AF | Recombinant Full Length Aspergillus Niger Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-305) | |
Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) | RFL21424AF | Recombinant Full Length Aspergillus Oryzae Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-292) | |
Aspergillus terreus (strain NIH 2624 / FGSC A1156) | RFL19647AF | Recombinant Full Length Aspergillus Terreus Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-296) | |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) | RFL5834CF | Recombinant Full Length Candida Albicans Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-294) | |
Coccidioides immitis (strain RS) (Valley fever fungus) | RFL35392CF | Recombinant Full Length Coccidioides Immitis Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-308) | |
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) | RFL14309CF | Recombinant Full Length Cryptococcus Neoformans Var. Neoformans Serotype D Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-294) | |
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) | RFL19581CF | Recombinant Full Length Cryptococcus Neoformans Var. Neoformans Serotype D Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-294) | |
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) | RFL2683EF | Recombinant Full Length Emericella Nidulans Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-310) | |
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) | RFL31590LF | Recombinant Full Length Lodderomyces Elongisporus Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-300) | |
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) | RFL13457MF | Recombinant Full Length Magnaporthe Oryzae Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-309) | |
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii) | RFL9336MF | Recombinant Full Length Meyerozyma Guilliermondii Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-284) | |
Mortierella alpina (Oleaginous fungus) (Mortierella renispora) | RFL29579MF | Recombinant Full Length Mortierella Alpina Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-298) | |
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus) | RFL7545NF | Recombinant Full Length Neosartorya Fischeri Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-309) | |
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) | RFL3468NF | Recombinant Full Length Neosartorya Fumigata Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-309) | |
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | RFL27271NF | Recombinant Full Length Neurospora Crassa Nadh-Cytochrome B5 Reductase 1(Cbr-1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-310) | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | RFL24169SF | Recombinant Full Length Saccharomyces Cerevisiae Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-284) | |
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) | RFL29433SF | Recombinant Full Length Saccharomyces Cerevisiae Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-284) | |
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) | RFL27208SF | Recombinant Full Length Scheffersomyces Stipitis Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-284) | |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | RFL27370SF | Recombinant Full Length Schizosaccharomyces Pombe Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-301) | |
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) | RFL469UF | Recombinant Full Length Ustilago Maydis Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-324) | |
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus) | RFL36478VF | Recombinant Full Length Vanderwaltozyma Polyspora Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-285) | |
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) | RFL28254YF | Recombinant Full Length Yarrowia Lipolytica Nadh-Cytochrome B5 Reductase 1(Cbr1) Protein, His-Tagged | E.coli expression system | His | Full Length (1-290) | |
Zebrafish | CBR1-9756Z | Recombinant Zebrafish CBR1 | Mammalian Cell | His | ||
Chicken | CBR1-2494C | Recombinant Chicken CBR1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
CBR1 involved in several pathways and played different roles in them. We selected most pathways CBR1 participated on our site, such as Arachidonic acid metabolism, Metabolism of xenobiotics by cytochrome P, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arachidonic acid metabolism | PLA2G6;CYP2U1;CYP2AD6;FAAH2;GGT5;CYP1A2;CYP2P8;GPX7;CYP2C70 |
Metabolism of xenobiotics by cytochrome P | CBR2;UGT1A4;UGT5G1;MGST1;MGST3;ALDH3B2;EPHX1;CYP1A;UGT1A9 |
Metabolic pathways | EXTL3;NDUFA4L;GANC;UGT1AB;ATP6V0A1B;GMPPAA;PIK3C2G;ADSL;DPM3 |
Chemical carcinogenesis | GSTA5;UGT1A7C;AKR1C2;CYP3A4;ADH1;UGT2A1;CYP1A1;GSTM4;UGT2A3 |
CBR1 has several biochemical functions, for example, 15-hydroxyprostaglandin dehydrogenase (NADP+) activity, carbonyl reductase (NADPH) activity, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by CBR1 itself. We selected most functions CBR1 had, and list some proteins which have the same functions with CBR1. You can find most of the proteins on our site.
Function | Related Protein |
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15-hydroxyprostaglandin dehydrogenase (NADP+) activity | |
carbonyl reductase (NADPH) activity | CBR3;DHRS4;CBR1;DHRS2;CBR2 |
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | AKR1C6;AKR1C4;AKR1C3;AKR1C21;CBR1;DCXR;NDUFS7;AKR1C2;DHRS4 |
prostaglandin-E2 9-reductase activity |
CBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CBR1.
PRKAB1; EIF1B; EPB41; VDAC1; NME2; MCC; HLA-B; HLA-C; EIF6; GABARAPL2; IKBKE; ATG101; DDA1; UBA5; FTSJ1; TNIK; TRAF6; EGFR; ERCC8
- Q&As
- Reviews
Q&As (6)
Ask a questionGene knockout or knockdown techniques can be used to study the function and mechanism of action of CBR1 proteins. By knocking out or knocking down CBR genes, changes in processes such as cholesterol metabolism and fatty acid synthesis can be observed to further understand their functions and mechanisms of action.
Immunohistochemistry and other methods can be used to analyze the effect of phosphorylation modification of CBR1 protein on its function. Studies have shown that phosphorylation modification can affect the activity and expression level of CBR1 protein, which in turn affects processes such as cholesterol metabolism and fatty acid synthesis.
Yeast two-hybridization, co-immunoprecipitation and other methods can be used to study the interaction of CBR1 protein with other proteins. These methods can determine the types and sites of interacting proteins, and further reveal the regulatory mechanism of CBR1 protein in cells.
The metabolic pathway of CBR1 protein can be analyzed using isotope labeling techniques. The labeled isotope is introduced into the cell or tissue.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of CBR1 protein by detecting the expression level of CBR1 protein and understanding its mechanism of action.
The expression level of CBR1 protein can be regulated through drug interventions, such as the use of cholesterol synthesis inhibitors, fatty acid synthesis inhibitors, etc. These drugs can inhibit the activity or expression level of CBR1 protein, thus achieving the purpose of treating diseases.
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