ccr3
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  • Official Full Name
  • chemokine (C-C motif) receptor 3
  • Background
  • The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.
  • Synonyms
  • CCR3; chemokine (C-C motif) receptor 3; CKR3; CD193; CMKBR3; CC-CKR-3; MGC102841; C-C chemokine receptor type 3; CCR-3; C-C CKR-3; OTTHUMP00000209745; b-chemokine receptor; CC chemokine receptor 3; eosinophil eotaxin receptor; eosinophil CC chemokine receptor; Chemokine (C C motif) receptor 3; Chemokine (CC) receptor 1 like 2; Eosinophil CC chemokine receptor 3; Macrophage inflammatory protein 1 alpha receptor like 2; OTTHUMP00000164718; OTTHUMP00000209746; OTTHUMP00000209747; OTTHUMP00000209748; CD193 antigen
Cat.#:CCR3-0690HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR3 Protein
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Cat.#:CCR3-0691HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCR3 Protein, GST-Tagged
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Cat.#:CCR3-10884HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCR3, GST-tagged
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Cat.#:CCR3-3015MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCR3 Protein
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Cat.#:CCR3-1228RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCR3 Protein
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Cat.#:CCR3-378CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CCR3 Protein, His-tagged
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Cat.#:CCR3-706RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCR3 Protein, His-tagged
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Cat.#:CCR3-7694HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCR3 293 Cell Lysate
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Cat.#:Kit-1639Tag:
Source (Host):Species:
Product nameCCR3 CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-0985Tag:
Source (Host):Species:
Product nameFluorimetric Hydrogen Peroxide Assay Kit (Near Infrared Fluorescence)
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Cat.#:CSC-RG0200Tag:
Source (Host):Species:Human
Product nameHuman CCR3-FLAG Stable Cell Line-HEK293T Galphaqi5
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Cat.#:CSC-RG0201Tag:
Source (Host):Species:Human
Product nameHuman CCR3-FLAG Stable Cell Line-HEK293T
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Cat.#:CSC-RG0630Tag:
Source (Host):Species:Human
Product nameHuman CCR3/Galpha15 Stable Cell Line-Chem-1
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Involved Pathway

CCR3 involved in several pathways and played different roles in them. We selected most pathways CCR3 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine receptors bind chemokines
AMCF-II; CCR3; CXCR7B; CCL19A.2; CCR8; CCBP2; CXCL13; CCR1; CCR6; CCR7
Chemokine signaling pathway
GRK5; SHC2; ARRB1; SRC; PLCB1; ROCK1; PIK3R5; RAP1B; GNG11; CCL11
Class A/1 (Rhodopsin-like receptors)
OPN1SW; UTS2D; NPB; LPAR1; OPN5; CCR7; NMU; CCR8; ADRA2B; OPN4.1
Cytokine-cytokine receptor interaction
TNFRSF25; FAS; TNF; IL17RB; Ccl21a; CSF2; IL7; TNFRSF8; CCL25; IL6ST
G alpha (i) signalling events
SSTR3; NPB; FPR-RS4; CHRM2; CCR7; PMCH; RLN3; RGS18; ANXA1; OPN1LW1
GPCR downstream signaling
NMB; AGT; ADRB3; CRHR2; NPSR1; ADM; SST1.1; CCL35.1; NPFF; ARHGEF16
GPCR ligand binding
PROK2; GAL; CX3CR1; OPN4; LPAR5A; PTGDR2; RCA2.1; SSTR1; GPR31; PENKA
GPCRs, Class A Rhodopsin-like
SSTR4; FFAR3; GPR75; GPR39; AGTR2; PTGDR2; FPR-RS4; SSTR2; GPR171; GPR68

Protein Function

CCR3 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR3 itself. We selected most functions CCR3 had, and list some proteins which have the same functions with CCR3. You can find most of the proteins on our site.
Function
Related Protein
Function C-C chemokine receptor activity
Related Protein CCBP2; CCR1L1; CCR3; CCR6A; CCR5; CCR8; CCR10; GPR75; CCR9; CCR1
Function chemokine receptor activity
Related Protein CCR6A; GPR17; ACKR4; CMKLR1; CCRL2; CCR1; CXCR4A; CCR9; CCR6; CCR3
Function protein binding
Related Protein PIAS3; MED9; NPM3; MYBPHL; DYNLRB1; FAM129A; NOXA1; PSMD5; ATF6B; TXLNA

Interacting Protein

CCR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR3.
CCL11

CCR3 Related Articles

Sugaya, M; et al. Chemokines and Skin Diseases. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 63:109-115(2015).
Makita, N; Hizukuri, Y; et al. IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration. INTERNATIONAL IMMUNOLOGY 27:131-141(2015).

CCR3 Related Gene Family

Chemokines Cytokines