|Official Full Name||CD44 molecule (Indian blood group)|
|Background||The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]|
|Synonyms||CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CD44 involved in several pathways and played different roles in them. We selected most pathways CD44 participated on our site, such as ECM-receptor interaction, Hematopoietic cell lineage, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD44 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ECM-receptor interaction||COL4A6; SV2B; THBS2; ITGB3B; ITGA6B; FN1; LAMA1; LAMB1; COL1A1A; TNR|
|Hematopoietic cell lineage||HLA-DRB1; TNF; HLA-DRB4; CD1B; MME; GP1BB; IL1R2; FCGR1A; IL11RA; CD3E; CD3D|
|Shigellosis||ACTB; U2AF1L4; MAPK8; RAC1; MAPK13; ELMO1; ABL1; SRC; FBXW11; HCLS1|
|Epstein-Barr virus infection||ENTPD8; HSPA1A; HLA-DPA1; YWHAZ; FGR; PIK3R1; NFKBIB; SYK; TRAF2; PSMC1|
|Proteoglycans in cancer||MAPK1; WNT10B; MSN; PLAUR; HOXD10; PTPN11; HSPB2; MAPK12; FZD1; LUM|
|MicroRNAs in cancer||RASSF1; CCND1; PTGS2; CCNG1; ROCK1; SPRY2; DICER1; SHC4; IRS2; MAPK1|
CD44 has several biochemical functions, for example, collagen binding, contributes_to cytokine receptor activity, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD44 itself. We selected most functions CD44 had, and list some proteins which have the same functions with CD44. You can find most of the proteins on our site.
|collagen binding||CTSK; ANTXR1; CTSB; ASPN; C1QTNF1; HSD17B12; MRC2; SERPINH1B; FN1; CD44|
|contributes_to cytokine receptor activity||IRX1; CD44; IL28RA|
|hyaluronic acid binding||VCANB; CD44; HAPLN1; TNFAIP6; VCAN; KIAA1199; HAPLN2; HYAL2; HMMR; IMPG2|
|hyalurononglucosaminidase activity||MGEA5; CD44; HYAL1; HYAL2; SPAM1; HYAL4; HYAL6; HYAL3; KIAA1199|
|protein binding||C14orf166; FCGR2C; TESC; CRB1; ROBO1; FAM176B; MRPL45; OBFC1; MGST1; ID2|
CD44 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD44 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD44.
ipaB; SPP1; ganglioside_gm1; SLC7A11; MSN