cd44
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  • Official Full Name
  • CD44 molecule (Indian blood group)
  • Background
  • The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
  • Synonyms
  • CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system;
Cat.#:Cd44-1017RATag:Fc
Source (Host):NS0 CellsSpecies:Rat
Product nameRecombinant Rat Cd44 protein, Fc-tagged, APC labeled
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Cat.#:Cd44-1017RPTag:Fc
Source (Host):NS0 CellsSpecies:Rat
Product nameRecombinant Rat Cd44 protein, Fc-tagged, R-PE labeled
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Cat.#:CD44-3095HATag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44 protein, Fc-tagged, APC labeled
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Cat.#:CD44-3095HPTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44 protein, Fc-tagged, R-PE labeled
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Cat.#:CD44-393HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD44 Protein (21-606 aa), His-SUMO-tagged
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Cat.#:Cd44-624MATag:Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Cd44 protein, Fc-tagged, APC labeled
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Cat.#:Cd44-624MPTag:Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Cd44 protein, Fc-tagged, R-PE labeled
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Cat.#:CD44-891MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD44 Protein (Met1-Thr224), His-tagged
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Cat.#:CD44-0820HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD44 Protein
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Cat.#:CD44-3095HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44 Protein, Fc-tagged
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Cat.#:CD44-3096HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44 Protein, MYC/DDK-tagged
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Cat.#:CD44-1412HTag:N/A
Source (Host):Cell CultureSpecies:Human
Product nameRecombinant Human CD44 Molecule (Indian Blood Group)
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Cat.#:CD44-10956HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD44, His-tagged
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Cat.#:CD44-27238THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD44 protein, GST-tagged
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Cat.#:CD44-3961HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44, His tagged
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Cat.#:CD44-421HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44, Fc tagged
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Cat.#:CD44-578HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human CD44, Fc-tagged, Biotinylated
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Cat.#:CD44-589HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD44 protein, GST-tagged
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Cat.#:Cd44-624MTag:Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Cd44 Protein, Fc Chimera
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Cat.#:Cd44-1017RTag:Fc
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Cd44 Protein, Fc Chimera
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Cat.#:CD44-6423CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD44
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Cat.#:CD44-1090HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD44 cell lysate
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Involved Pathway

CD44 involved in several pathways and played different roles in them. We selected most pathways CD44 participated on our site, such as ECM-receptor interaction, Hematopoietic cell lineage, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD44 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ECM-receptor interaction
COL5A2A; LAMC2; COL1A1; FN1A; ITGA7; COL6A5; ITGA2B; GP5; VWF; ITGA3B
Hematopoietic cell lineage
IL1R2; CD36; ITGA3; CD5; Itga10&Itgb1; CD7; IL3RA; THPO; CD34; GM-CSF
Shigellosis
PFN4; MAPK9; RAC1; U2AF1; MAD2L2; MAPK1; MAPK13; ITGB1; SRC; CD44
Epstein-Barr virus infection
NFKBIA; HDAC4; EIF2AK4; POLR2D; XPO1; POLR3F; MAPK10; POLR2F; POLR3C; PIK3CA
Proteoglycans in cancer
CBLC; CAV3; PXN; WNT3; PRKCA; TLR2; ITGA2; ITGB1; VAV2; NUDT16L1
MicroRNAs in cancer
PTGS2; NOTCH1; FOXP1; TP53; KIF23; VIM; IGF2BP1; PDGFB; EZH2; PRKCA

Protein Function

CD44 has several biochemical functions, for example, collagen binding, contributes_to cytokine receptor activity, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD44 itself. We selected most functions CD44 had, and list some proteins which have the same functions with CD44. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein LUM; ITGA3; Itga10&Itgb1; TGFBI; Pdgfa&Pdgfb; SERPINH1B; MMP13; PODN; CTSK; CTSB
Function contributes_to cytokine receptor activity
Related Protein IRX1; IL28RA; CD44
Function hyaluronic acid binding
Related Protein BCAN; KIAA1199; CD44; TNFAIP6; LYVE1; NCAN; HAPLN4; STAB2; IMPG2; C1QBP
Function hyalurononglucosaminidase activity
Related Protein HYAL3; CD44; HYAL1; HYAL4; MGEA5; SPAM1; HYAL2; HYAL6; KIAA1199
Function protein binding
Related Protein CBLB; TRPC1; C3orf62; TOMM20; VAV2; ZNF643; ZNF436; TBX3; PPP1R16A; NINJ1

Interacting Protein

CD44 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD44 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD44.
ipaB; SPP1; ganglioside_gm1; SLC7A11; MSN

CD44 Related Articles

Gu, JJ; Fang, XL; et al. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. BIOMATERIALS 45:99-114(2015).
Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).