CD44 Protein, CD44 molecule (Indian blood group)

CD44

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CD44

Official Full Name CD44 molecule (Indian blood group)
Background The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Synonyms CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • SUMO
    • human
    • IgG1
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD44-001H Recombinant Human CD44 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Cd44-1017RA Recombinant Rat Cd44 protein, Fc-tagged, APC labeled NS0 Fc
    Rat Cd44-1017RP Recombinant Rat Cd44 protein, Fc-tagged, R-PE labeled NS0 Fc
    Human CD44-3095HA Recombinant Human CD44 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CD44-3095HP Recombinant Human CD44 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD44-393H Recombinant Human CD44 Protein (21-606 aa), His-SUMO-tagged E.coli His/SUMO
    Mouse Cd44-624MA Recombinant Mouse Cd44 protein, Fc-tagged, APC labeled CHO Fc
    Mouse Cd44-624MP Recombinant Mouse Cd44 protein, Fc-tagged, R-PE labeled CHO Fc
    Mouse CD44-891M Recombinant Mouse CD44 Protein (Met1-Thr224), His-tagged HEK293 His
    Human CD44-0820H Recombinant Human CD44 Protein Wheat Germ N/A
    Human CD44-1090HCL Recombinant Human CD44 cell lysate Human Cell N/A
    Human CD44-10956H Recombinant Human CD44, His-tagged E.coli His
    Human CD44-1412H Recombinant Human CD44 Molecule (Indian Blood Group) N/A
    Human CD44-27238TH Recombinant Human CD44 protein, GST-tagged Wheat Germ GST
    Human CD44-3095H Recombinant Human CD44 protein, Fc-tagged (HPLC-verified) HEK293 human/IgG1/Fc
    Human CD44-3096H Recombinant Human CD44 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD44-3961H Recombinant Human CD44 protein, His-tagged HEK293 His
    Human CD44-421H Recombinant Human CD44, Fc tagged Human Cell His
    Human CD44-578H Recombinant Human CD44, Fc-tagged, Biotinylated Human Cell Fc
    Human CD44-589H Recombinant Human CD44 protein, GST-tagged E.coli GST
    Mouse Cd44-624M Recombinant Mouse Cd44 Protein, Fc Chimera CHO Fc
    Rat Cd44-1017R Recombinant Rat Cd44 Protein, Fc Chimera NS0 Fc
    Chicken CD44-6423C Recombinant Chicken CD44 Mammalian Cell His

    CD44 involved in several pathways and played different roles in them. We selected most pathways CD44 participated on our site, such as ECM-receptor interaction, Hematopoietic cell lineage, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD44 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ECM-receptor interaction COL4A6; SV2B; THBS2; ITGB3B; ITGA6B; FN1; LAMA1; LAMB1; COL1A1A; TNR
    Hematopoietic cell lineage HLA-DRB1; TNF; HLA-DRB4; CD1B; MME; GP1BB; IL1R2; FCGR1A; IL11RA; CD3E; CD3D
    Shigellosis ACTB; U2AF1L4; MAPK8; RAC1; MAPK13; ELMO1; ABL1; SRC; FBXW11; HCLS1
    Epstein-Barr virus infection ENTPD8; HSPA1A; HLA-DPA1; YWHAZ; FGR; PIK3R1; NFKBIB; SYK; TRAF2; PSMC1
    Proteoglycans in cancer MAPK1; WNT10B; MSN; PLAUR; HOXD10; PTPN11; HSPB2; MAPK12; FZD1; LUM
    MicroRNAs in cancer RASSF1; CCND1; PTGS2; CCNG1; ROCK1; SPRY2; DICER1; SHC4; IRS2; MAPK1

    CD44 has several biochemical functions, for example, collagen binding, contributes_to cytokine receptor activity, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD44 itself. We selected most functions CD44 had, and list some proteins which have the same functions with CD44. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding CTSK; ANTXR1; CTSB; ASPN; C1QTNF1; HSD17B12; MRC2; SERPINH1B; FN1; CD44
    contributes_to cytokine receptor activity IRX1; CD44; IL28RA
    hyaluronic acid binding VCANB; CD44; HAPLN1; TNFAIP6; VCAN; KIAA1199; HAPLN2; HYAL2; HMMR; IMPG2
    hyalurononglucosaminidase activity MGEA5; CD44; HYAL1; HYAL2; SPAM1; HYAL4; HYAL6; HYAL3; KIAA1199
    protein binding C14orf166; FCGR2C; TESC; CRB1; ROBO1; FAM176B; MRPL45; OBFC1; MGST1; ID2

    CD44 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD44 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD44.

    ipaB; SPP1; ganglioside_gm1; SLC7A11; MSN

    Gu, JJ; Fang, XL; et al. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. BIOMATERIALS 45:99-114(2015).
    Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).

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