cdkn1b
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  • Official Full Name
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • Background
  • Cyclin-dependent kinase inhibitor 1B is an enzyme that in humans is encoded by the CDKN1B gene. It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. It is often referred to as a cell cycle inhibitor protein because its major function is to stop or slow down the cell division cycle.
  • Synonyms
  • CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); KIP1; MEN4; CDKN4; MEN1B; P27KIP1; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; p27Kip1; OTTHUMP00000195098; OTTHUMP00000195099; kinase inhibitory protein (Kip1)
Cat.#:CDKN1B-1056HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CDKN1B Protein, GST-Tagged
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Cat.#:CDKN1B-2499HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1), His-tagged
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Cat.#:CDKN1B-006HTag:DDK
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human CDKN1B Protein, DDK-tagged
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Cat.#:CDKN1B-1478HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN1B, GST-tagged
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Cat.#:CDKN1B-313HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN1B protein, His/MBP-tagged
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Cat.#:CDKN1B-33HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN1B protein, GST-tagged
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Cat.#:CDKN1B-4729HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CDKN1B, His-tagged
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Cat.#:Cdkn1b-1252MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cdkn1b protein, His & T7-tagged
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Cat.#:CDKN1B-3221MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CDKN1B Protein
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Cat.#:CDKN1B-794RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CDKN1B Protein, His-tagged
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Cat.#:CDKN1B-5829CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CDKN1B
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Cat.#:CDKN1B-7617HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CDKN1B 293 Cell Lysate
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Involved Pathway

CDKN1B involved in several pathways and played different roles in them. We selected most pathways CDKN1B participated on our site, such as AKT phosphorylates targets in the cytosol, Adaptive Immune System, AhR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AKT phosphorylates targets in the cytosol
CHUK; CDKN1A; AKT3; CDKN1B
Adaptive Immune System
FGF10B; ASB4; AGO1; CTSB; SIGLEC6; HCST; KIF20A; UBA5; RAPGEF3; DYNC1I1
AhR pathway
CDKN1A; FLG; AHRR; EGFR; NQO1; JUN; AIP; AHR; CYP1A2; CYP1B1
C-MYB transcription factor network
PRTN3; CDKN1B; TOM1; CSF1R; PPID; MYB; CLTA; SMARCA2; ADA; GATA1
Cell Cycle
DYRK1A; GSK3B; SGOL2; CEP57; MCM8; CHEK2; SYCP2; SPDL1; RBBP8; DBF4
Cell Cycle Checkpoints
FAM175A; CHEK1; HTATIP; MCM10; RNF168; CDK2; BARD1; MCM8; TP53BP1; YWHAQ
Cell Cycle, Mitotic
CLASP1A; TUBGCP2; CDCA5; ARPP19B; GINS1; KIF18A; CEP57; CDKN2D; CSNK2B; ZW10

Protein Function

CDKN1B has several biochemical functions, for example, Hsp70 protein binding, chaperone binding, cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1B itself. We selected most functions CDKN1B had, and list some proteins which have the same functions with CDKN1B. You can find most of the proteins on our site.
Function
Related Protein
Function Hsp70 protein binding
Related Protein L7RN6; DNAJB2; DNAJB1; DNAJA1; ST13; TSACC; CDKN1B; STIP1; METTL21A; C11orf73
Function chaperone binding
Related Protein CDKN1B; PACRG; TRP53; CDC37; INS1; SDF2L1; AHSA1L; DNAJB5; CALR; FGB
Function cyclin-dependent protein serine/threonine kinase inhibitor activity
Related Protein CDKN1BB; KAT2B; CDKN2A; CDKN1BA; CDKN2C; INCA1; CDKN1D; HEXIM1; CDKN2D; CDKN1B
Function contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein CDKN1B; NKX3; NKX3-1
Function protein binding
Related Protein MYL2; FOXM1; EPS8L1; CCDC70; SLIRP; NR4A3; SNRNP27; PTTG1IP; RBM15; CHD1
Function protein complex binding
Related Protein GIT1; ANKRD54; PTCH1; C8B; CDKN1B; HADHA; PEX1; NCK2; KRIT1; FBLN1
Function protein phosphatase binding
Related Protein GRB2; PPP1R3G; KAT2A; SHOC2; JUPA; EGFR; HSF4; ERBB2; MVP; PPP1R3C
Function transforming growth factor beta receptor, cytoplasmic mediator activity
Related Protein CDKN1B; ENG

Interacting Protein

CDKN1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1B.
CDK2

CDKN1B Related Articles

Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
Cattoretti, G; et al. MYC expression and distribution in normal mature lymphoid cells. JOURNAL OF PATHOLOGY 229:430-440(2013).