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CES3

Official Full Name

carboxylesterase 3
Overview

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.
Synonyms

CES3; carboxylesterase 3; carboxylesterase 3 (brain); brain carboxylesterase BR3; ES31; esterase 31; FLJ21736; ES3; CES 3; Liver carboxylesterase 31 homolog;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Zebrafish

Source

E.coli
HEK293
Human Cell
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CES3-899H	Recombinant Human CES3, His tagged	Human Cell	His		$699 / 50 µg
Human	CES3-898H	Recombinant Human CES3, GST-tagged	E.coli	GST		Inquiry
Human	CES3-1151H	Recombinant Human CES3 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CES3-636HCL	Recombinant Human CES3 cell lysate		N/A		Inquiry
Human	CES3-3264HF	Recombinant Full Length Human CES3 Protein, GST-tagged	In Vitro Cell Free System	GST	568 amino acids	Inquiry
Human	CES3-3198H	Recombinant Human CES3 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CES3-897H	Recombinant Human CES3 protein, His-tagged	E.coli	His	Ser398~Gln568	$298 / 10ug
Human	CES3-1922HFL	Recombinant Full Length Human CES3 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	CES3-580H	Recombinant Human CES3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	CES3-580H-B	Recombinant Human CES3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	CES3-4035Z	Recombinant Zebrafish CES3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CES3 Related Research Area

CES3 involved in several pathways and played different roles in them. We selected most pathways CES3 participated on our site, such as E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
E2F transcription factor network	CEBPA;DHFR;RYBP;HIC1;E2F6;UXT;CES1;YY1;RBBP8

CES3 has several biochemical functions, for example, sterol esterase activity, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES3 itself. We selected most functions CES3 had, and list some proteins which have the same functions with CES3. You can find most of the proteins on our site.

Function	Related Protein
sterol esterase activity	CES1;CEL.1;CES1D;CES3;Cel;LIPA;CES5A
triglyceride lipase activity	PNLIPRP3;LIPF;PNPLA2;LIPE;CES1D;CEL.1;PNPLA4;Cel;CES3

CES3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES3.

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Serine Proteases and Regulators