ces3
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  • Official Full Name
  • carboxylesterase 3
  • Background
  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.
  • Synonyms
  • CES3; carboxylesterase 3; carboxylesterase 3 (brain); brain carboxylesterase BR3; ES31; esterase 31; FLJ21736; ES3; CES 3; Liver carboxylesterase 31 homolog
Cat.#:CES3-1151HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CES3 Protein, GST-Tagged
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Cat.#:CES3-3198HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CES3 Protein, MYC/DDK-tagged
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Cat.#:CES3-898HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CES3, GST-tagged
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Cat.#:CES3-899HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CES3, His tagged
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Cat.#:CES3-4035ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CES3
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Cat.#:CES3-636HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human CES3 cell lysate
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Involved Pathway

CES3 involved in several pathways and played different roles in them. We selected most pathways CES3 participated on our site, such as E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with CES3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
E2F transcription factor network
DHFR; CBX5; MYBL2; PRMT5; CES3; CDKN2C; E2F6; HIC1; SMARCA2; RBBP8

Protein Function

CES3 has several biochemical functions, for example, sterol esterase activity, triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CES3 itself. We selected most functions CES3 had, and list some proteins which have the same functions with CES3. You can find most of the proteins on our site.
Function
Related Protein
Function sterol esterase activity
Related Protein Cel; CES1; LIPA; CEL.1; CES5A; CES3; CES1D
Function triglyceride lipase activity
Related Protein PNPLA4; CES3; PNLIPRP1; Cel; CES5A; PNLIPRP2; PNLIPRP3; CEL.1; PNLIP; LIPCA

Interacting Protein

CES3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CES3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CES3.
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