Recombinant Full Length Human CES3 Protein, C-Flag-tagged

• Cat.No.: CES3-1922HFL
• Product Overview: Recombinant Full Length Human CES3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 62.1 kDa
• AA Sequence: MERAVRVESGVLVGVVCLLLACPAT ATGPEVAQPEVDTTLGRVRGRQVGV KGTDRLVNVFLGIPFAQPPL GPDRFSAPHPAQPWEGVRDASTAPP MCLQDVESMNSSRFVLNGKQQIFSV SEDCLVLNVYSPAEVPAGSG RPVMVWVHGGALITGAATSYDGSAL AAYGDVVVVTVQYRLGVLGFFSTGD EHAPGNQGFLDVVAALRWVQ ENIAPFGGDLNCVTVFGGSAGGSII SGLVLSPVAAGLFHRAITQSGVITT PGIIDSHPWPLAQKIANTLA CSSSSPAEMVQCLQQKEGEELVLSK KLKNTIYPLTVDGTVFPKSPKELLK EKPFHSVPFLMGVNNHEFSW LIPRGWGLLDTMEQMSREDMLAIST PVLTSLDVPPEMMPTVIDEYLGSNS DAQAKCQAFQEFMGDVFINV PTVSFSRYLRDSGSPVFFYEFQHRP SSFAKIKPAWVKADHGAEGAFVFGG PFLMDESSRLAFPEATEEEK QLSLTMMAQWTHFARTGDPNSKALP PWPQFNQAEQYLEINPVPRAGQKFR EAWMQFWSETLPSKIQQWHQ KQKNRKAQEDL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: CES3 carboxylesterase 3 [ Homo sapiens (human) ]
• Official Symbol: CES3
• Synonyms: ES31
• Gene ID: 23491
• mRNA Refseq: NM_024922.6
• Protein Refseq: NP_079198.2
• MIM: 605279
• UniProt ID: Q6UWW8