cfi
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  • Official Full Name
  • complement factor I
  • Background
  • Complement factor I, also known as C3B/C4B inactivator, is a protein that in humans is encoded by the CFI gene. Complement Factor I (fI) is a protein of the complement system, first isolated in 1966 in guinea pig serum that regulates complement activation by cleaving cell-bound or fluid phase C3b and C4b.
  • Synonyms
  • CFI; complement factor I; I factor (complement) , IF; C3b INA; C3b inactivator; FI; KAF; Konglutinogen activating factor; C3b-inactivator; C3B/C4B inactivator; complement component I; light chain of factor I; Konglutinogen-activating factor; complement fa
Cat.#:CFI-2054HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFI protein, His & GST-tagged
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Cat.#:CFI-290HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFI protein, His-tagged
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Cat.#:CFI-9302HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CFI protein, His-tagged
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Cat.#:Cfi-2055MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cfi protein, His-tagged
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Cat.#:CFI-3349MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CFI Protein
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Cat.#:CFI-1355RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CFI Protein
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Cat.#:CFI-4700CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CFI
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Cat.#:CFI-105HTag:
Source (Host):Species:Human
Product nameNative Human Factor I
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Cat.#:CFI-7556HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CFI 293 Cell Lysate
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Involved Pathway

CFI involved in several pathways and played different roles in them. We selected most pathways CFI participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFI were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
SERPINA1E; CR1L; CFH; KNG1; FGA; F7; C8B; C1R; MBL1; C3
Staphylococcus aureus infection
FPR3; C1S; DSG1A; FCGR4; HLA-DQA2; FCGR1A; FCGR3; CFI; FPR2; MBL1

Protein Function

CFI has several biochemical functions, for example, metal ion binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFI itself. We selected most functions CFI had, and list some proteins which have the same functions with CFI. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein TET3; PRSS37; RC3H2; PFKP; ZFP598; GALNTL1; ME2; MT1; ESRRGB; AGO2
Function protein binding
Related Protein HDHD3; FBXO17; PODXL; SGTB; DUSP23; ZFAND5; ABCD1; CD27; OSTC; PPIA
Function scavenger receptor activity
Related Protein TMPRSS3; CD163; ENPP1; VTNB; SCART1; TMPRSS5; LOXL2A; TINAG; VTN; LOXL2B
Function serine-type endopeptidase activity
Related Protein TMPRSS4A; MCPT2; HGFA; TMPRSS3; PCSK1; GM5077; C1RA; CFD; CTSG; KLK14

Interacting Protein

CFI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFI here. Most of them are supplied by our site. Hope this information will be useful for your research of CFI.
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CFI Related Articles

Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
Ardissino, G; Testa, S; et al. Discontinuation of Eculizumab Maintenance Treatment for Atypical Hemolytic Uremic Syndrome: A Report of 10 Cases. AMERICAN JOURNAL OF KIDNEY DISEASES 64:633-637(2014).