chrm2
Share
  • Official Full Name
  • cholinergic receptor, muscarinic 2
  • Background
  • The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
  • Synonyms
  • CHRM2; cholinergic receptor, muscarinic 2; HM2; FLJ43243; MGC120006; MGC120007; muscarinic acetylcholine receptor M2; 7TM receptor; OTTHUMP00000208393; OTTHUMP00000208394; OTTHUMP00000208395; OTTHUMP00000208396; muscarinic M2 receptor; cholinergic receptor, muscarinic 2, isoform a; Muscarinic receptors; mAChRs
Cat.#:CHRM2-1270HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHRM2 Protein
+Inquiry
Cat.#:CHRM2-1271HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHRM2 Protein, GST-Tagged
+Inquiry
Cat.#:CHRM2-175HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CHRM2
+Inquiry
Cat.#:CHRM2-3425MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CHRM2 Protein
+Inquiry
Cat.#:CHRM2-1386RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CHRM2 Protein
+Inquiry
Cat.#:CHRM2-2464CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHRM2
+Inquiry
Cat.#:CHRM2-7520HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CHRM2 293 Cell Lysate
+Inquiry
Cat.#:Kit-0875Tag:
Source (Host):Species:
Product nameContinuous AMP Deaminase Assay Kit
+Inquiry
Cat.#:Kit-1167Tag:
Source (Host):Species:
Product nameCHRM2 Activated GPCR Internalization Assay Kit
+Inquiry
Cat.#:Kit-1168Tag:
Source (Host):Species:
Product nameCHRM2 CHO-K1 β-Arrestin GPCR Assay Kit
+Inquiry
Cat.#:Kit-1169Tag:
Source (Host):Species:
Product namecAMP CHRM2 CHO-K1 GPCR Assay Kit
+Inquiry
Cat.#:Kit-1057Tag:
Source (Host):Species:
Product nameLactose Colorimetric/Fluorometric Assay Kit
+Inquiry
Cat.#:CSC-RG0066Tag:
Source (Host):Species:Human
Product nameHuman CHRM2 Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-RG0317Tag:
Source (Host):Species:Human
Product nameHuman CHRM2-FLAG Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-RG0502Tag:
Source (Host):Species:Human
Product nameHuman CHRM2/Gi Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-RG0596Tag:
Source (Host):Species:Human
Product nameHuman CHRM2/Galpha15 Stable Cell Line-Chem-1
+Inquiry

Involved Pathway

CHRM2 involved in several pathways and played different roles in them. We selected most pathways CHRM2 participated on our site, such as Amine ligand-binding receptors, Arf6 trafficking events, Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amine ligand-binding receptors
DRD1; DRD3; ADRA2B; DRD2; ADRB1; CHRM4; CHRM2; ADRA1B; ADRa1A; ADRB3
Arf6 trafficking events
JUP; EXOC5; SCAMP2; EDNRB; CTNND1; CLTC; PTBP3; EXOC3; CTNNA1; EXOC6
Calcium Regulation in the Cardiac Cell
CASQ1; ADRB1; RGS17; CHRM3; GJA3; GJC2; CHRM5; RGS20; CX35.4; GJB6
Calcium signaling pathway
PLCD1B; STIM2; TACR1; SLC25A5; AGTR1; EDNRAA; ATP2A1L; PLCB1; P2RX5; PTGER3
Cholinergic synapse
PRKCG; GNB2; CREB3L2; KCNQ1; KCNQ5; CHRNA6; BCL2; PLCB1; AKT1; PIK3CD
Class A/1 (Rhodopsin-like receptors)
GAL; PROKR2; SSTR5; ADRB2; OXGR1; KEL; HEBP1; AGTR2; PYYA; GPR17
G alpha (i) signalling events
TAS2R7; LPAR2A; CHRM2; OXER1; AMCF-II; SSTR4; CXCL11.8; CXCR7B; POMCB; GPR55A
GPCR downstream signaling
CGA; DGKG; CCR8; QRFP; RASGRP2; GNA13; SOUL3; KALRN; OPN4A; CHRM5

Protein Function

CHRM2 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM2 itself. We selected most functions CHRM2 had, and list some proteins which have the same functions with CHRM2. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled acetylcholine receptor activity
Related Protein CHRM2; CHRM5; CHRM5A; CHRM3; CHRM2A; CHRM5B; CHRM4; CHRM1
Function drug binding
Related Protein HTR2B; MTOR; CHKA; ADH1; PYGM; CYP4B1; PDXK; DCK; CHRNB2; FABP1

Interacting Protein

CHRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM2.
GPRASP1; GPRASP2; af-dx 384; methoctramine; Lamp1; Arrb2

CHRM2 Related Articles

Riese, H; Munoz, LM; et al. Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway. PLOS ONE 9:-(2014).
Srivastava, P; Yadav, RS; et al. Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY 279:428-440(2014).