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CHRM2

  • Official Full Name

    cholinergic receptor, muscarinic 2

  • Overview

    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
  • Synonyms

    CHRM2; cholinergic receptor, muscarinic 2; HM2; FLJ43243; MGC120006; MGC120007; muscarinic acetylcholine receptor M2; 7TM receptor; OTTHUMP00000208393; OTTHUMP00000208394; OTTHUMP00000208395; OTTHUMP00000208396; muscarinic M2 receptor; cholinergic receptor, muscarinic 2, isoform a; Muscarinic receptors; mAChRs;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHRM2-482H Recombinant Human CHRM2 Full Length Transmembrane protein, Flag Tag(Nanodisc) HEK293 Flag
Human CHRM2-175H Recombinant Human CHRM2 Mammalian Cell His
Human CHRM2-1271H Recombinant Human CHRM2 Protein, GST-Tagged Wheat Germ GST
Human CHRM2-1270H Recombinant Human CHRM2 Protein Wheat Germ N/A
Human CHRM2-7520HCL Recombinant Human CHRM2 293 Cell Lysate HEK293 N/A
Human CHRM2-2672H Recombinant Human CHRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CHRM2-301527H Recombinant Human PCHRM2 protein, GST-tagged E.coli GST Ser210-Ala373
Human CHRM2-2672H-B Recombinant Human CHRM2 Protein Pre-coupled Magnetic Beads HEK293
Human CHRM2-1094HFL Recombinant Human CHRM2 protein, His&Flag-tagged HEK293 His&Flag 1-466 aa
Human CHRM2-3221HF Recombinant Full Length Human CHRM2 Protein In Vitro Cell Free System 303 amino acids
Mouse CHRM2-3425M Recombinant Mouse CHRM2 Protein Mammalian Cell His
Mouse CHRM2-1659M-B Recombinant Mouse CHRM2 Protein Pre-coupled Magnetic Beads HEK293
Mouse CHRM2-1659M Recombinant Mouse CHRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CHRM2-1386R Recombinant Rat CHRM2 Protein Mammalian Cell His
Rat CHRM2-1044R-B Recombinant Rat CHRM2 Protein Pre-coupled Magnetic Beads HEK293
Rat CHRM2-1044R Recombinant Rat CHRM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL36400BF Recombinant Full Length Bovine Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-465)
Gallus gallus (Chicken) RFL16764GF Recombinant Full Length Chicken Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-466)
Homo sapiens (Human) RFL35358HF Recombinant Full Length Human Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-466)
Mus musculus (Mouse) RFL20261MF Recombinant Full Length Mouse Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-466)
Pan troglodytes (Chimpanzee) RFL19287PF Recombinant Full Length Pan Troglodytes Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-440)
Rattus norvegicus (Rat) RFL33112RF Recombinant Full Length Rat Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-466)
Sus scrofa (Pig) RFL6942SF Recombinant Full Length Pig Muscarinic Acetylcholine Receptor M2(Chrm2) Protein, His-Tagged E.coli expression system His Full Length (1-466)
Chicken CHRM2-2464C Recombinant Chicken CHRM2 Mammalian Cell His
Kit-0875 Continuous AMP Deaminase Assay Kit N/A
Kit-1168 CHRM2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1167 CHRM2 Activated GPCR Internalization Assay Kit N/A
Kit-1057 Lactose Colorimetric/Fluorometric Assay Kit N/A
Kit-1169 cAMP CHRM2 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CHRM2 Related Articles
  • CHRM2 Related Research Area

CHRM2 involved in several pathways and played different roles in them. We selected most pathways CHRM2 participated on our site, such as Amine ligand-binding receptors, Arf6 trafficking events, Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsDRD5;DRD1;ADRA2B;CHRM5;CHRM1;ADRA1D;ADRB3;DRD4;ADRB1
Arf6 trafficking eventsSPAG9;SCAMP2;ADRB2;EXOC1;CTNND1;JUP;EXOC5;EXOC3;DNM2
Calcium Regulation in the Cardiac CellGNG13B;GJC2;GNB5B;KCNJ5;GJB1;CX44.1;RGS14;ADRB1;RGS10
Calcium signaling pathwayPRKACBB;NOS2A;PDGFRB;CAMK2G;PLCD1A;GNAL;PLCZ1;CALM3;STIM2
Cholinergic synapseMAP2K1;PIK3R5;CHRM2;PRKACA;CHRNB2;PRKCB;CHRM3;KCNQ1;KCNQ3
Class A/1 (Rhodopsin-like receptors)CCR1;PTGDR2;GPR132;RLN2;PROK2;POMCB;CHRM4;OPN1MW;PNOC
G alpha (i) signalling eventsFPR-RS3;RGS18;HEBP1;NMU;AGTR2;OXGR1A.1;APPB;TAS2R7;AMCF-II
GPCR downstream signalingHEBP1;VIP;CALCB;ADCYAP1R1;ABR;CXCL11.8;TRPC3;CXCL13;DRD5

CHRM2 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM2 itself. We selected most functions CHRM2 had, and list some proteins which have the same functions with CHRM2. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled acetylcholine receptor activityCHRM2A;CHRM5;CHRM4;CHRM1;CHRM3;CHRM5B;CHRM5A;CHRM2
drug bindingHTR2C;PDE2A;PYGM;FOLR2;MTOR;GRIK1;CHRNA2;PDE4D;PIGC

CHRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM2.

GPRASP1; GPRASP2; af-dx 384; methoctramine; Lamp1; Arrb2

Riese, H; Munoz, LM; et al. Identifying Genetic Variants for Heart Rate Variability in the Acetylcholine Pathway. PLOS ONE 9:-(2014).
Srivastava, P; Yadav, RS; et al. Unraveling the mechanism of neuroprotection of curcumin in arsenic induced cholinergic dysfunctions in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY 279:428-440(2014).
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