CHRM3 Protein, cholinergic receptor, muscarinic 3


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Official Full Name cholinergic receptor, muscarinic 3
Background The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
Synonyms CHRM3; cholinergic receptor muscarinic 3; CHRM 3; HM3; M3 muscarinic receptor; muscarinic 3; Muscarinic M3 Receptor (a.a. 580-589); Muscarinic M3 Receptor; muscarinic acetylcholine receptor M3; OTTHUMP00000037632
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • B2M
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHRM3-1362H Recombinant Human CHRM3 Protein (253-492 aa), His-tagged Yeast His
    Human CHRM3-2276H Recombinant Human CHRM3 Protein (253-492 aa), His-B2M-tagged E.coli His/B2M
    Human CHRM3-1272H Recombinant Human CHRM3 Protein Wheat Germ N/A
    Human CHRM3-1273H Recombinant Human CHRM3 Protein, GST-Tagged Wheat Germ GST
    Human CHRM3-7519HCL Recombinant Human CHRM3 293 Cell Lysate HEK293 N/A
    Rat CHRM3-1387R Recombinant Rat CHRM3 Protein Mammalian Cell His
    Rhesus Macaque CHRM3-860R Recombinant Rhesus monkey CHRM3 Protein, His-tagged Mammalian Cell His
    Chicken CHRM3-6950C Recombinant Chicken CHRM3 Mammalian Cell His
    Kit-1007 Cell Migration/Chemotaxis Assay Kit (96-well, 5 μm) N/A
    Kit-1170 CHRM3 U2OS β-Arrestin GPCR Assay Kit N/A
    Kit-1171 CHRM3 Total GPCR Internalization Assay Kit N/A

    CHRM3 involved in several pathways and played different roles in them. We selected most pathways CHRM3 participated on our site, such as Acetylcholine regulates insulin secretion, Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Acetylcholine regulates insulin secretion MARCKSA; CHRM3; MARCKSB
    Amine ligand-binding receptors DRD3; CHRM1; ADRA2A; TAAR1; ADRA1B; CHRM5; CHRM2; ADRA1D; ADRA2C; ADRA2B
    Calcium Regulation in the Cardiac Cell CX34.4; RGS4; KCNJ5; RGS10; GJC2; GJB3; KCNB1; CHRM3; RGS11; GJA8
    Calcium signaling pathway GRIN2C; ATP2B1; PLCD3A; P2RX4; PTAFR; CAMK2D; P2RX3A; ITPR1; BDKRB1; ATP2A2B
    Cholinergic synapse GNB4; CREB3L4; AKT1; PLCB2; CREB3L2; KCNJ3; PRKCA; CHAT; ITPR1; PRKCG
    Class A/1 (Rhodopsin-like receptors) OPN1MW2; GPR39; SST; GPR65; EDN2; CXCR6; SSTR1; CXCL13; SSTR4; OXTRL
    G alpha (q) signalling events GCGB; CHRM3; GPR132; LPAR1; OXTRL; EDN1; GPR68; TRIO; NMS; GPR17
    GPCR downstream signaling ABR; TIAM2; ADM2; ARHGEF1A; GCGB; NPFF; ECT2; TAS2R7; SST; NMBB

    CHRM3 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity, acetylcholine binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM3 itself. We selected most functions CHRM3 had, and list some proteins which have the same functions with CHRM3. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled acetylcholine receptor activity CHRM5; CHRM1; CHRM4; CHRM3; CHRM5A; CHRM2A; CHRM5B; CHRM2
    acetylcholine binding CHRNA3; CHRNA7; CHRNB2; CHRNB3; CHRNA4; CHRM3; CHRFAM7A; CHRNB1; ACHE
    drug binding PPARG; PPP3CA; DRD1A; PNP; GPR30; GRIK1; HTR2A; P2RX4; PDE4D; DHODH
    phosphatidylinositol phospholipase C activity CHRM3; PLCD1A; PLCD3; PLCD1; CCR5; CHRM1; CCKBR; PLCB3; PLCB4; PLCE1
    protein binding ARF5; SLC22A6; LARP4; AIPL1; NCSTN; PENK; TXNRD1; MAB21L3; NEBL; NR0B2
    receptor activity PVR; NLGN2; MED24; VMN1R49; CADM2A; VMN1R40; Tnfrsf22; TNFRSF6B; PLAUR; ITGB3A

    CHRM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM3.


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