chrnb2
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  • Official Full Name
  • cholinergic receptor, nicotinic, beta 2 (neuronal)
  • Background
  • Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy.
  • Synonyms
  • Acetylcholine receptor beta 2 neural; ACHB2_HUMAN; ACHN; Acrb 2; Acrb2; b2 nAchR; Cholinergic receptor nicotinic beta 2; Cholinergic receptor nicotinic beta polypeptide 2; Cholinergic receptor nicotinic beta polypeptide 2 neuronal; CHRNB2; EFNL 3; EFNL3; nAChRB2; Neuronal acetylcholine receptor protein beta 2 chain precursor; Neuronal acetylcholine receptor protein subunit beta 2; Neuronal acetylcholine receptor subunit beta-2; Neuronal nicotinic acetylcholine receptor beta 2; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); Nicotinic beta 2 Receptor; OTTHUMP00000035374; Nicotinic beta 2 (carboxyl terminal) Receptor
Cat.#:CHRNB2-1286HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CHRNB2 Protein, GST-Tagged
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Cat.#:CHRNB2-11217HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CHRNB2, His-tagged
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Cat.#:CHRNB2-1397RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CHRNB2 Protein
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Cat.#:CHRNB2-864RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CHRNB2 Protein, His-tagged
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Cat.#:CHRNB2-6376CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CHRNB2
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Cat.#:CHRNB2-7512HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CHRNB2 293 Cell Lysate
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Involved Pathway

CHRNB2 involved in several pathways and played different roles in them. We selected most pathways CHRNB2 participated on our site, such as Acetylcholine Binding And Downstream Events, Activation of Nicotinic Acetylcholine Receptors, Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Acetylcholine Binding And Downstream Events
CHRNA4; CHRNA2; CHRNA3; CHRNA1; CHRND; CHRNB4; CHRNB2; CHRNE; CHRNA7; CHRNA5
Activation of Nicotinic Acetylcholine Receptors
CHRNA4; CHRNA2; CHRNE; CHRNB2; CHRNA7; CHRNA1; CHRNB4; CHRND; CHRNA5; CHRNA3
Cholinergic synapse
GNG7; ITPR1; GNG3; FYN; KCNQ2; GNAQ; CHRNA4; GNG12; KCNJ2; KCNJ12
Highly calcium permeable nicotinic acetylcholine receptors
CHRNA1; CHRNA2; CHRNB4; CHRNA4; CHRNB2; CHRNA5; CHRNA3
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
CHRNA2; CHRNA5; CHRNA1; CHRNB4; CHRNB2; CHRNA4; CHRNA3; CHRNA7
Highly sodium permeable acetylcholine nicotinic receptors
CHRNA4; CHRNB2; CHRNE; CHRND; CHRNB4; CHRNA3
Neuroactive ligand-receptor interaction
CHRNA5; GPR35; GPR156; P2RX4A; GALR2; GLRA3; TAAR14B; MCHR1; VIPR1B; PTGER1
Neuronal System
KCNN1; CCDC167; CPLX1; KCNA5; KCNK1A; CHRNA7; KCNB2; STXBP1A; SLC1A2A; ABCC9

Protein Function

CHRNB2 has several biochemical functions, for example, acetylcholine binding, acetylcholine receptor activity, acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRNB2 itself. We selected most functions CHRNB2 had, and list some proteins which have the same functions with CHRNB2. You can find most of the proteins on our site.
Function
Related Protein
Function acetylcholine binding
Related Protein CHRNA7; CHRNB3; CHRM3; CHRNB1; CHRNB2; CHRFAM7A; ACHE; CHRNA3; CHRNA4
Function acetylcholine receptor activity
Related Protein CHRNA3; CHRNA5; CHRNA4; CHRNB4; CHRNA6; CHRNB2; ANXA9; CHRNE; CHRNA7; CHRNA2
Function acetylcholine-activated cation-selective channel activity
Related Protein CHRNB1L; CHRNB3; CHRNB4; CHRNE; CHRNA2A; CHRNB2; CHRNA1; Chrng; CHRNB3A; CHRNA10A
Function drug binding
Related Protein SFRP1; TOP2A; CHRNA3; CHRNB4; MT2A; FABP1; HTR1B; PYGB; CYP2D6; PNP
Function ligand-gated ion channel activity
Related Protein CLCA5; P2RX2; ZACN; CNGA3; Chrng; GABRB1; CHRNB1; ANXA6; CLCA2; CHRNA5
Function protein binding
Related Protein CD82; C1orf50; TMPRSS7; PDCL; TEKT1; WDYHV1; IL17A; FNTB; PPP6R2; SUPT5H
Function protein heterodimerization activity
Related Protein GABPB2; TFAP2E; KATNA1; SOX9; TAL1; HIST1H2BP; ADD2; ARNT2; H3F3B.1; PPARD

Interacting Protein

CHRNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRNB2.
CHRNA5; CHRNA4; CHRNA3