CLEC4A Protein, C-type lectin domain family 4, member A

CLEC4A

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CLEC4A

Official Full Name C-type lectin domain family 4, member A
Background A member of the calcium-dependent (C-type) lectin receptor (CLR) family, DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM). A mouse cDNA, encoding a homologous protein has been identified. Northern blot analysis shows that DCIR mRNA is predominantly transcribed in hematopoietic tissues. DCIR displays a typical lectin CRD and is expressed on DCs, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DCs derived from blood monocytes cultured with GM-CSF and IL-4. DCIR is preferentially expressed by monocyte-related rather than Langerhans cell related DCs obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF- . Thus, DCIR is differentially expressed on DCs depending on their origin and stage of maturation/activation. DCIR represents a novel surface molecule expressed by antigen-presenting cells, and of potential importance in regulation of DC function.
Synonyms DCIR; LLIR; DDB27; CLECSF6; HDCGC13P; C-type lectin domain family 4 member A; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; OTTHUMP00000239071; OTTHUMP00000239070; OTTHUMP00000239052; CLEC4A
    • Species :
    • Human
    • Mouse
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse CLEC4A-2212M Recombinant Mouse CLEC4A Protein (70-238 aa), His-SUMO-Myc-tagged E.coli His/SUMO/Myc
    Human CLEC4A-1467H Recombinant Human CLEC4A Protein, GST-tagged Wheat Germ GST
    Human CLEC4A-2282HCL Recombinant Human CLEC4A cell lysate Human Cell N/A
    Human CLEC4A-3353H Recombinant Human CLEC4A, His tagged Human Cell His
    Rhesus monkey CLEC4A-1791R Recombinant Rhesus Monkey CLEC4A Protein HEK293 N/A

    CLEC4A involved in several pathways and played different roles in them. We selected most pathways CLEC4A participated on our site, such as C-type lectin receptors (CLRs), Dectin-2 family, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-type lectin receptors (CLRs) AHCYL1; ITPR2; IL1B2; CLEC4A; UBE2V1; CLEC4D; CASP8L1; CREBBP; CLEC6A; MALT1
    Dectin-2 family CLEC6A; CLEC4A; CLEC4D
    Immune System KLHL21; Siglece; GHRB; RNF216; CTSK; PELI3; POLR3GLA; DEFA1; CLEC2B; CFHL3
    Innate Immune System CFHL3; CLEC5A; DEFB125; CNPY3; ABI1A; ABI2; DEFB119; MB21D1; CFD; POLR3C

    CLEC4A has several biochemical functions, for example, carbohydrate binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4A itself. We selected most functions CLEC4A had, and list some proteins which have the same functions with CLEC4A. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding FBXO2; LGALS4; KRT1; SIGLEC7; CD22; GALNT12; LGALS2B; GANC; OS9; ILLR3
    transmembrane signaling receptor activity NCR2; FZD7A; DCC; CLEC4A; FZD1; IL27RA; GPR113; CALCRLA; CD3G; ERBB3

    CLEC4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4A.

    Ishibashi, M; Morita, N; et al. CLEC4M-positive and CD81-negative Huh7 cells are not susceptible to JFH-1 HCVcc infection but mediate transinfection. ARCHIVES OF VIROLOGY 159:2949-2955(2014).
    Wang, MY; Wang, FP; et al. Mannan-Binding Lectin Inhibits Candida albicans-Induced Cellular Responses in PMA-Activated THP-1 Cells through Toll-Like Receptor 2 and Toll-Like Receptor 4. PLOS ONE 8:-(2013).

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