COL10A1 Protein, collagen, type X, alpha 1


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Official Full Name collagen, type X, alpha 1
Background This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
Synonyms COL10A1; collagen, type X, alpha 1; collagen alpha-1(X) chain; collagen X, alpha-1 polypeptide; Schmid metaphyseal chondrodysplasia<br/>
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Col10a1-915M Recombinant Mouse Col10a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human COL10A1-490H Recombinant Human COL10A1 protein, His-tagged E.coli His
    Human COL10A1-85H Recombinant Human COL10A1, His-tagged Insect Cell His
    Human COL10A1-88H Recombinant Human COL10A1, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Col10a1-350M Recombinant Mouse Col10a1 Protein, His-tagged E.coli His
    Mouse COL10A1-3713M Recombinant Mouse COL10A1 Protein Mammalian Cell His
    Rhesus monkey COL10A1-1769R Recombinant Rhesus monkey COL10A1 protein, His-tagged E.coli His
    Rhesus Macaque COL10A1-959R Recombinant Rhesus monkey COL10A1 Protein, His-tagged Mammalian Cell His
    Bovine COL10A1-348B Recombinant Bovine COL10A1 Protein, His-tagged E.coli His

    COL10A1 involved in several pathways and played different roles in them. We selected most pathways COL10A1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL10A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of collagen fibrils and other multimeric structures COL1A1; CTSL1; LOXL2; COL4A6; COL3A1; COL8A2; COL8A1A; CTSL2; LOX; COL11A1B
    Collagen biosynthesis and modifying enzymes PCOLCE2; COL4A4; COL9A1B; COL6A2; COL5A1; TLDC2; COL9A1A; COL8A1; COL17A1; PCOLCEB
    Collagen formation COL10A1; COL1A2; MMP13; COL13A1; CTSL2; LOXL1; LOXL3; COL5A2; COL15A1B; ADAMTS2
    Endochondral Ossification MGP; KIF3A; NKX3-2; CDKN1C; COL10A1; COL2A1; NKX3.2; ADAMTS4; SOX9A; ADAMTS1
    Extracellular matrix organization CTSK; FURINA; TTR; BMP1B; COL17A1; FMOD; ADAMTS1; LOC100686744; ADAMTS3; COL9A1A
    Protein digestion and absorption CELA2B; COL15A1; ATP1A2; COL18A1; SLC9A3; COL6A4; DPP4; MEP1A; ATP1B2; XPNPEP2
    Senescence and Autophagy ATG7; IGFBP7; IGFBP5; IFI16; GABARAP; FKBP8; MAP1LC3C; UVRAG; IL24; ING1

    COL10A1 has several biochemical functions, for example, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL10A1 itself. We selected most functions COL10A1 had, and list some proteins which have the same functions with COL10A1. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding NOS2A; PHLPP2; PDE8A; PPM1LB; PPM1E; MMP14A; TIMM8A2; GLI1; BMP1B; ZNF143B
    protein binding APLF; PLEKHO1; TFF1; TRADD; CBX1; LRRC33; HIST1H2AK; STMN1; VPREB1; MYOC

    COL10A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL10A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL10A1.


    Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
    Alaseem, AM; Madiraju, P; et al. Naproxen Induces Type X Collagen Expression in Human Bone-Marrow-Derived Mesenchymal Stem Cells Through the Upregulation of 5-Lipoxygenase. Tissue Engineering Part A 21:234-245(2015).

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