• Official Full Name
  • Corin, serine peptidase
  • Background
  • Corin, also known as Atrial Natriuretic Peptide-converting enzyme, is a 1042 amino acid single-pass type II membrane protein that is found on the cell membrane. It is highly expressed in the heart and heart myocytes. Corin is a serine-type endopeptidase that is involved in atrial natriuretic peptide hormone processing. It converts, through proteolytic cleavage, the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. Corin may also process pro-NPPB the B-type natriuretic peptide. Enzyme regulation is inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine. Corin is N-glycosylated, which is required for processing and activation. It is consists of a disulfide bond that links the N- terminal propeptide and the activated Corin protease fragment. Corin is activated through proteolytic processing by a trypsin-like protease: cleaved into an N-terminal propeptide and an activated Corin protease fragment. It is initially named Corin due to its abundant expression in the heart.
  • Synonyms
  • ATC2; CRN; Lrp4; PEE5; TMPRSS10; atrial natriuretic peptide-converting enzyme; heart-specific serine proteinase ATC2; pro-ANP-convertase; pro-ANP-converting enzyme; transmembrane protease serine 10
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CORIN Protein, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human CORIN Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CORIN Protein, His/GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CORIN Protein, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Corin Protein, His-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Corin Protein, His-tagged
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Corin Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CORIN
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CORIN Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CORIN Protein

Involved Pathway

CORIN involved in several pathways and played different roles in them. We selected most pathways CORIN participated on our site, such as Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CORIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Myometrial Relaxation and Contraction Pathways

Protein Function

CORIN has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CORIN itself. We selected most functions CORIN had, and list some proteins which have the same functions with CORIN. You can find most of the proteins on our site.
Related Protein
Function serine-type endopeptidase activity
Related Protein HTRA3; ST14A; HTRA1A; KLK14; F2; FAP; PLG; PLAUB; PLAU; PRSS42

CORIN Related Articles

Foo, JYY; Wan, YX; et al. Circulating Fragments of N-Terminal Pro-B-Type Natriuretic Peptides in Plasma of Heart Failure Patients. CLINICAL CHEMISTRY 59:1523-1531(2013).
Peleg, A; Jaffe, AS; et al. Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood. CLINICA CHIMICA ACTA 409:85-89(2009).

CORIN Related Gene Family