Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

CORIN

  • Official Full Name

    Corin, serine peptidase

  • Overview

    Corin, also known as Atrial Natriuretic Peptide-converting enzyme, is a 1042 amino acid single-pass type II membrane protein that is found on the cell membrane. It is highly expressed in the heart and heart myocytes. Corin is a serine-type endopeptidase that is involved in atrial natriuretic peptide hormone processing. It converts, through proteolytic cleavage, the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. Corin may also process pro-NPPB the B-type natriuretic peptide. Enzyme regulation is inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine. Corin is N-glycosylated, which is required for processing and activation. It is consists of a disulfide bond that links the N- terminal propeptide and the activated Corin protease fragment. Corin is activated through proteolytic processing by a trypsin-like protease: cleaved into an N-terminal propeptide and an activated Corin protease fragment. It is initially named Corin due to its abundant expression in the heart.
  • Synonyms

    ATC2; CRN; Lrp4; PEE5; TMPRSS10; atrial natriuretic peptide-converting enzyme; heart-specific serine proteinase ATC2; pro-ANP-convertase; pro-ANP-converting enzyme; transmembrane protease serine 10;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CORIN-1722H Recombinant Human CORIN Protein, GST-tagged Wheat Germ GST
Human CORIN-745H Recombinant Human CORIN Mammalian Cell His
Human CORIN-274HFL Active Recombinant Full Length Human CORIN Protein, C-Flag-tagged Mammalian cells Flag
Human CORIN-644H Recombinant Human CORIN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CORIN-1702H Recombinant Human CORIN Protein (Gly70-Thr136), N-GST tagged E.coli N-GST Gly70-Thr136
Human CORIN-5605H Recombinant Human CORIN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CORIN-644H-B Recombinant Human CORIN Protein Pre-coupled Magnetic Beads HEK293
Human CORIN-3308H Recombinant Human CORIN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CORIN-438H Recombinant Human CORIN Protein, His/GST-tagged E.coli His/GST Gly70~Thr136
Human CORIN-439H Recombinant Human CORIN Protein, His-tagged E.coli His Ser448~Glu579
Mouse CORIN-3796M Recombinant Mouse CORIN Protein Mammalian Cell His
Mouse Corin-443M Recombinant Mouse Corin Protein, His-tagged E. coli His
Mouse Corin-2271M Recombinant Mouse Corin Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse CORIN-1902M Recombinant Mouse CORIN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Corin-442M Recombinant Mouse Corin Protein, His-tagged E.coli His Ser521~Thr637
Mouse CORIN-1902M-B Recombinant Mouse CORIN Protein Pre-coupled Magnetic Beads HEK293
Rat CORIN-1544R Recombinant Rat CORIN Protein Mammalian Cell His
Rat CORIN-1201R Recombinant Rat CORIN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CORIN-1201R-B Recombinant Rat CORIN Protein Pre-coupled Magnetic Beads HEK293
Rat Corin-444R Recombinant Rat Corin Protein, His-tagged E.coli His Pro533~Gln634
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CORIN Related Articles
  • CORIN Related Gene Family
  • CORIN Related Research Area

CORIN involved in several pathways and played different roles in them. We selected most pathways CORIN participated on our site, such as Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CORIN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Myometrial Relaxation and Contraction PathwaysCNN1;CNN2;RGS20;ACTA1;CRCP;MAFF;GUCA2A;IGFBP6;RXFP2

CORIN has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CORIN itself. We selected most functions CORIN had, and list some proteins which have the same functions with CORIN. You can find most of the proteins on our site.

Function Related Protein
serine-type endopeptidase activityC1rb;CTRB1;TMPRSS11F;KLK14;PRSS50;TRY;ST14B;CELA2B;HTRA4

CORIN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CORIN here. Most of them are supplied by our site. Hope this information will be useful for your research of CORIN.

Foo, JYY; Wan, YX; et al. Circulating Fragments of N-Terminal Pro-B-Type Natriuretic Peptides in Plasma of Heart Failure Patients. CLINICAL CHEMISTRY 59:1523-1531(2013).
Peleg, A; Jaffe, AS; et al. Enzyme-linked immunoabsorbent assay for detection of human serine protease corin in blood. CLINICA CHIMICA ACTA 409:85-89(2009).
TGF
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All CORIN Products

Required fields are marked with *

My Review for All CORIN Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends