Active Recombinant Full Length Human CORIN Protein, C-Flag-tagged

• Cat.No.: CORIN-274HFL
• Product Overview: Recombinant Full Length Human CORIN Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Enzyme activity
• Molecular Mass: 116.3 kDa
• AA Sequence: MKQSPALAPEERCRRAGSPKPVLRA DDNNMGNGCSQKLATANLLRFLLLV LIPCICALVLLLVILLSYVG TLQKVYFKSNGSEPLVTDGEIQGSD VILTNTIYNQSTVVSTAHPDQHVPA WTTDASLPGDQSHRNTSACM NITHSQCQMLPYHATLTPLLSVVRN MEMEKFLKFFTYLHRLSCYQHIMLF GCTLAFPECIIDGDDSHGLL PCRSFCEAAKEGCESVLGMVNYSWP DFLRCSQFRNQTESSNVSRICFSPQ QENGKQLLCGRGENFLCASG ICIPGKLQCNGYNDCDDWSDEAHCN CSENLFHCHTGKCLNYSLVCDGYDD CGDLSDEQNCDCNPTTEHRC GDGRCIAMEWVCDGDHDCVDKSDEV NCSCHSQGLVECRNGQCIPSTFQCD GDEDCKDGSDEENCSVIQTS CQEGDQRCLYNPCLDSCGGSSLCDP NNSLNNCSQCEPITLELCMNLPYNS TSYPNYFGHRTQKEASISWE SSLFPALVQTNCYKYLMFFSCTILV PKCDVNTGEHIPPCRALCEHSKERC ESVLGIVGLQWPEDTDCSQF PEENSDNQTCLMPDEYVEECSPSHF KCRSGQCVLASRRCDGQADCDDDSD EENCGCKERDLWECPSNKQC LKHTVICDGFPDCPDYMDEKNCSFC QDDELECANHACVSRDLWCDGEADC SDSSDEWDCVTLSINVNSSS FLMVHRAATEHHVCADGWQEILSQL ACKQMGLGEPSVTKLIQEQEKEPRW LTLHSNWESLNGTTLHELLV NGQSCESRSKISLLCTKQDCGRRPA ARMNKRILGGRTSRPGRWPWQCSLQ SEPSGHICGCVLIAKKWVLT VAHCFEGRENAAVWKVVLGINNLDH PSVFMQTRFVKTIILHPRYSRAVVD YDISIVELSEDISETGYVRP VCLPNPEQWLEPDTYCYITGWGHMG NKMPFKLQEGEVRIISLEHCQSYFD MKTITTRMICAGYESGTVDS
  CMGDSGGPLVCEKPGGRWTLFGLTS WGSVCFSKVLGPGVYSNVSYFVEWI KRQIYIQTFLLNTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Transmembrane

Gene Information

• Gene Name: CORIN corin, serine peptidase [ Homo sapiens (human) ]
• Official Symbol: CORIN
• Synonyms: CRN; ATC2; Lrp4; PEE5; TMPRSS10
• Gene ID: 10699
• mRNA Refseq: NM_006587.4
• Protein Refseq: NP_006578.2
• MIM: 605236
• UniProt ID: Q9Y5Q5