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COX7A2L

Official Full Name

cytochrome c oxidase subunit VIIa polypeptide 2 like
Overview

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.
Synonyms

COX7A2L; cytochrome c oxidase subunit VIIa polypeptide 2 like; cytochrome c oxidase subunit 7A-related protein, mitochondrial; COX7AR; COX7RP; EB1; SIG81; COX7a related protein; Cytochrome c oxidase subunit VIIa related protein, mitochondrial; Estrogen receptor binding CpG island; COX7a-related protein; cytochrome c oxidase subunit VII-related protein; cytochrome c oxidase subunit VIIa-related protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COX7A2L-1761H	Recombinant Human COX7A2L Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COX7A2L-16H	Recombinant Human COX7A2L protein, His-tagged	E.coli	His		Inquiry
Human	COX7A2L-11501H	Recombinant Human COX7A2L, His-tagged	E.coli	His	1-114a.a.	$319 / 25ug
Human	COX7A2L-7325HCL	Recombinant Human COX7A2L 293 Cell Lysate	HEK293	N/A		Inquiry
Human	COX7A2L-2717H	Recombinant Human COX7A2L protein, GST-tagged	E.coli	GST	1-114aa	Inquiry
Human	COX7A2L-2015HF	Recombinant Full Length Human COX7A2L Protein, GST-tagged	In Vitro Cell Free System	GST	114 amino acids	Inquiry
Rhesus Macaque	COX7A2L-995R	Recombinant Rhesus monkey COX7A2L Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	COX7A2L-820R	Recombinant Rhesus Macaque COX7A2L Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	COX7A2L-820R-B	Recombinant Rhesus Macaque COX7A2L Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	COX7A2L-4970C	Recombinant Chicken COX7A2L	Mammalian Cell	His		Inquiry
Chicken	COX7A2L-4971C	Recombinant Chicken COX7A2L	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

COX7A2L involved in several pathways and played different roles in them. We selected most pathways COX7A2L participated on our site, such as Oxidative phosphorylation, Cardiac muscle contraction, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with COX7A2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	ATP6V0A1A;ATP6V1BA;NDUFB2;ATP6V0E1;COX11;ATP6V1G3;ATP6V0A4;NDUFB4;NDUFA9A
Cardiac muscle contraction	MYH7;SLC8A1;ATP1B3;MYL4;TNNC1;VMHC;RYR2;COX7A3;COX6A1
Non-alcoholic fatty liver disease (NAFLD)	IRS1;IL6R;ADIPOR2;NDUFC2-KCTD14;PIK3CG;NDUFB9;COX6B2;IL6;GSK3B
Alzheimers disease	ATP5G3;CALM2;COX6C;APH1B;MME;NDUFA13;COX7B;PLCB2;NDUFB11
Parkinsons disease	SLC6A3;SLC18A1;UCHL1;NDUFA7;ATP5J;NDUFC1;NDUFB6;NDUFA8;PRKACG
Huntingtons disease	NDUFA11;NDUFA8;POLR2H;UCP1;HAP1;VDAC3;NDUFB6;UQCRFS1;ATP5G3

COX7A2L has several biochemical functions, for example, cytochrome-c oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX7A2L itself. We selected most functions COX7A2L had, and list some proteins which have the same functions with COX7A2L. You can find most of the proteins on our site.

Function	Related Protein
cytochrome-c oxidase activity	COX5A;COX7A2L;COX4I1;CYB5A;COX7A2;COX6A2;COX8A;COA6;COX5B2

COX7A2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX7A2L here. Most of them are supplied by our site. Hope this information will be useful for your research of COX7A2L.

MAGEA11; NDUFS4; NDUFS5; TIMMDC1