crkl
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  • Official Full Name
  • v-crk sarcoma virus CT10 oncogene homolog (avian)-like
  • Background
  • CrkL, a 39 kDa adaptor protein, has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). The amino-terminal SH3 domain of CrkL binds proteins such as C3G, SOS, PI3K, c-Abl and BCR/Abl. The SH2
  • Synonyms
  • CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein
Cat.#:CRKL-1889HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CRKL Protein, GST-tagged
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Cat.#:CRKL-3324HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CRKL Protein, MYC/DDK-tagged
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Cat.#:CRKL-561HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRKL Protein, His-tagged
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Cat.#:CRKL-26624THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRKL, His-tagged
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Cat.#:CRKL-571HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CRKL
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Cat.#:CRKL-6997HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CRKL, His-tagged
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Cat.#:CRKL-1604RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CRKL Protein
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Cat.#:CRKL-1031RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CRKL Protein, His-tagged
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Cat.#:CRKL-12693ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CRKL
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Cat.#:CRKL-3373HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRKL, His-tagged
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Cat.#:CRKL-403HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CRKL cell lysate
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Involved Pathway

CRKL involved in several pathways and played different roles in them. We selected most pathways CRKL participated on our site, such as B Cell Receptor Signaling Pathway, Bacterial invasion of epithelial cells, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRKL were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
B Cell Receptor Signaling Pathway
NFKBIB; BLK; NEDD9; HRAS; MAP2K1; PIK3AP1; AKT1; DOK1; IFITM1; PIK3R2
Bacterial invasion of epithelial cells
CTNNA3; ARPC4; RAC1; SHC1; WASF1; ARPC1A; MAD2L2; CTTN; CBL; CRK
Chemokine signaling pathway
CCL25; NFKBIA; SHC4; GM13304; CXCL2; ADRBK2; STAT3; RASGRP2; GNG3; RLN1
Chronic myeloid leukemia
HDAC2; TP53; BCR; MECOM; CBLB; SHC4; TGFB2; TRP53; PIK3CB; CCND1
Cytokine Signaling in Immune system
ISG20; ARIH1L; RASGRP4; CSHL1; SAMHD1; TNFRSF13C; IFIT10; NRG4; IFITM3; LGALS9
Downstream signal transduction
DUSP9; DAB2IPB; SPRED1; PEA15; MOV10; FGF20A; FRS3; CRKL; AGO3; PHB
EGFR1 Signaling Pathway
KRT8; JUND; GRB7; CEBPB; SH3BGRL; STXBP1A; RGS5B; TNK2; RGS16; RALBB
EPHA forward signaling
ARHGEF15; EFNA2; EFNA3; CRKL; EFNA5; BLK; EPHA2; EFNA1

Protein Function

CRKL has several biochemical functions, for example, SH3/SH2 adaptor activity, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRKL itself. We selected most functions CRKL had, and list some proteins which have the same functions with CRKL. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein SRC; CHN2; SKAP1; SH3BP2; SH3BGR; ITSN2; GRB2; SH2D1A; ARHGAP1; CRK
Function poly(A) RNA binding
Related Protein FXR2; DDX52; ZNF622; GTF2F1; EIF4G1; GNB2L1; DAZAP1; P4HB; DIAPH1; CCDC86
Function protein binding
Related Protein KIF1C; HGF; DIS3L2; RCAN3; CDCA8; CCDC64B; ARMCX5-GPRASP2; NOP2; RP9; SH3BP4
Function signal transducer activity
Related Protein GPR158; CCR6A; TAS2R125; GNAZ; TRAF2; OLFR491; TAS2R201.1; PTGER2B; OLFR50; SHC3

Interacting Protein

CRKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRKL here. Most of them are supplied by our site. Hope this information will be useful for your research of CRKL.
CBL; GAB1; EGFR; Kcnma1

CRKL Related Articles

Lv, SZ; Zhang, J; et al. Nucleolin Promotes TGF-beta Signaling Initiation via TGF-beta Receptor I in Glioblastoma. JOURNAL OF MOLECULAR NEUROSCIENCE 55:1-6(2015).
Aspinall-O'Dea, M; Pierce, A; et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. NATURE PROTOCOLS 10:149-168(2015).