CRKL

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CRKL

Official Full Name v-crk sarcoma virus CT10 oncogene homolog (avian)-like
Background CrkL, a 39 kDa adaptor protein, has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). The amino-terminal SH3 domain of CrkL binds proteins such as C3G, SOS, PI3K, c-Abl and BCR/Abl. The SH2
Synonyms CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CRKL-1889H Recombinant Human CRKL Protein, GST-tagged Wheat Germ GST
    Human CRKL-26624TH Recombinant Human CRKL, His-tagged E.coli His
    Human CRKL-3324H Recombinant Human CRKL Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CRKL-3373H Recombinant Human CRKL, His-tagged E.coli His
    Human CRKL-403HCL Recombinant Human CRKL cell lysate N/A
    Human CRKL-561H Recombinant Human CRKL Protein, His-tagged E.coli His
    Human CRKL-571H Recombinant Human CRKL Mammalian Cell His
    Human CRKL-6997H Recombinant Human CRKL, His-tagged Sf9 Insect Cell His
    Rat CRKL-1604R Recombinant Rat CRKL Protein Mammalian Cell His
    Rhesus Macaque CRKL-1031R Recombinant Rhesus monkey CRKL Protein, His-tagged Mammalian Cell His
    Zebrafish CRKL-12693Z Recombinant Zebrafish CRKL Mammalian Cell His

    CRKL involved in several pathways and played different roles in them. We selected most pathways CRKL participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRKL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    B Cell Receptor Signaling Pathway PLEKHA1; PPP3CC; CD81; CDK4; MAP2K1; DOK3; PLCG2; ACTR3; NFKBIB; CD19
    Bacterial invasion of epithelial cells CTNNA1; ELMO3; SHC3; PIK3CG; PIK3R2; SEPT12; CBL; DNM3; CAV1; SEPT2
    Chemokine signaling pathway CX3CR1; GNB1; IL-8; RAP1A; NFKBIB; BRAF; GNGT1; SHC3; Ccl21c; CCR1L1
    Chronic myeloid leukemia BCR; ARAF; PIK3CA; TGFBR2; GRB2; SOS1; TRP53; PIK3CD; MAP2K2; KRAS
    Cytokine Signaling in Immune system DUSP1; EDARADD; GBP5; NOD1; GBP6; CNKSR1; IFITM3; TNIP2; CSK; PELI3
    Downstream signal transduction MOV10; FRS2B; FGF8B; GRB7; DUSP9; FGFR1B; PEA15; PTPRA; AGO3; LAMTOR2
    EGFR1 Signaling Pathway RGS16; CEBPA; KRT17; PTPN12; APPL2; PTK6; ELF3; DOK2; ZNF259; SH2D3C
    EPHA forward signaling EPHA2; BLK; ARHGEF15; EFNA2; EFNA3; EFNA5; CRKL; EFNA1

    CRKL has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CRKL itself. We selected most functions CRKL had, and list some proteins which have the same functions with CRKL. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity NCK1; SH2D2A; STAM; EPS8; SH3BP2; ITSN2; CD28; PTPN11; TOB1; SRC
    poly(A) RNA binding SCAF4; RG9MTD1; TBL3; RAN; ZC3H7A; GPATCH4; ARL6IP4; CCDC124; CASC3; C4BPA
    protein binding BNIP1; LOXL4; CXCL2; HIPK4; NFYC; EAF2; EPS15; WLS; ANG; SCUBE3
    signal transducer activity BST2; STAT5B; NDFIP2; F2RL2; SH2B2; V2RX1; PTGER1B; VMN1R49; TAAR7D; TAS2R130

    CRKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRKL here. Most of them are supplied by our site. Hope this information will be useful for your research of CRKL.

    CBL; GAB1; EGFR; Kcnma1

    Lv, SZ; Zhang, J; et al. Nucleolin Promotes TGF-beta Signaling Initiation via TGF-beta Receptor I in Glioblastoma. JOURNAL OF MOLECULAR NEUROSCIENCE 55:1-6(2015).
    Aspinall-O'Dea, M; Pierce, A; et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. NATURE PROTOCOLS 10:149-168(2015).

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